{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T13:23:28Z","timestamp":1772630608814,"version":"3.50.1"},"reference-count":54,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T00:00:00Z","timestamp":1634083200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2021,10,13]]},"abstract":"<jats:p>Background. Different parts of Brucea antidysenterica are used in traditional and alternative medicine in Ethiopia for the treatment of different health problems including malaria and have good in vitro antimalarial activity. However, no in vivo study was conducted to substantiate the claim. Our study planned to determine the antimalarial effect of B. antidysenterica extract. Methods. Swiss albino mice (6\u20138 weeks old, 20\u201328\u2009g) were inoculated with Plasmodium berghei. Different doses of both hydromethanolic extract and chloroform fraction were orally given at 100, 200, and 400\u2009mg\/kg\/day. Results. The parasitemia suppression percent of hydromethanolic crude extract and chloroform fraction in chemosuppressive tests ranged between 33.48 and 75.93% and 38.32 and 76.64%, respectively. The hydromethanolic crude extract and chloroform fraction exhibited the curative effect of 46.75\u201370.91% and 50.30\u201380.06% parasitemia suppression, respectively (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>p<\/a:mi>\n                     <\/a:math>\n                  <\/jats:inline-formula>\u2009&lt;\u20090.001), compared with negative control. Conclusion. From our study, it is concluded that the hydromethanolic crude extract and chloroform fraction of B. antidysenterica leaves showed promising antiplasmodial effects against Plasmodium berghei. This upholds the folkloric use of B. antidysenterica leaves and the thought of as a possible source to develop new antimalarial agents.<\/jats:p>","DOI":"10.1155\/2021\/2089114","type":"journal-article","created":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T19:24:03Z","timestamp":1634153043000},"page":"1-14","source":"Crossref","is-referenced-by-count":6,"title":["Antimalarial Activity of Hydromethanolic Crude Extract and Chloroform Fraction of Brucea antidysenterica Leaves in Plasmodium berghei-Infected Mice"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3941-1811","authenticated-orcid":true,"given":"Tezera Jemere","family":"Aragaw","sequence":"first","affiliation":[{"name":"Department of Pharmacology, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7317-2995","authenticated-orcid":true,"given":"Kefyalew Ayalew","family":"Getahun","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1186\/s40249-019-0542-8"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1179\/146532810x12858955921032"},{"key":"3","volume-title":"World Malaria Report 2015","author":"World Health Organization","year":"2016"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-ento-112408-085423"},{"key":"5","article-title":"Malaria in Ethiopia, lesson 14","author":"A. 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