{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:54:20Z","timestamp":1787756060920,"version":"build-2784847793"},"reference-count":44,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T00:00:00Z","timestamp":1629072000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["2018-XBQNXZ-B-006"],"award-info":[{"award-number":["2018-XBQNXZ-B-006"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["2018-YDYLTD-001"],"award-info":[{"award-number":["2018-YDYLTD-001"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]},{"name":"XTIPC","award":["2018-XBQNXZ-B-006"],"award-info":[{"award-number":["2018-XBQNXZ-B-006"]}]},{"name":"XTIPC","award":["2018-YDYLTD-001"],"award-info":[{"award-number":["2018-YDYLTD-001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2021,8,16]]},"abstract":"<jats:p>Kursi Wufarikun Ziyabit (KWZ) is a classic traditional medicine used for the prevention treatment of diabetes in China. It was widely used as healthcare tea in folk and can prevent and treat type 2 diabetes. However, the underlying mechanism of KWZ in type 2 diabetes has not been investigated extensively. Here, the weekly body weight and blood glucose level of KWZ in type 2 diabetes db\/db male mice were observed. After 4 weeks of treatment, the physiological changes and pharmacological effects of KWZ were investigated. The results showed that KWZ can significantly decrease fasting blood glucose and improve glucose tolerance and insulin sensitivity in db\/db mice. The serum\/liver lipid profiles such as LDL-C, TC, TG, and serum-free fatty acid\/Fructosamine levels were decreased, and the serum\/liver HDL-C levels were increased. In addition, significant improvement in glucose metabolism enzymes and antioxidant enzymes in experimental mice\u2019s livers was observed. Moreover, the expression of GRP78, p-IRE1\u03b1\/IRE1\u03b1, p-eIF2\u03b1\/eIF2\u03b1, and XBP1s was decreased. The expression of p-PERK\/PERK, p-Akt\/Akt, and p-GSK-3\u03b2\/GSK-3\u03b2 was markedly increased. These results suggested that KWZ is effective for type 2 diabetes by improving endoplasmic reticulum (ER) stress in the liver of db\/db mice, and it might prevent the damage of insulin Beta cells and alleviate insulin resistance.<\/jats:p>","DOI":"10.1155\/2021\/2100128","type":"journal-article","created":{"date-parts":[[2021,8,17]],"date-time":"2021-08-17T19:05:53Z","timestamp":1629227153000},"page":"1-10","source":"Crossref","is-referenced-by-count":4,"title":["Kursi Wufarikun Ziyabit Improves the Physiological Changes by Regulating Endoplasmic Reticulum Stress in the Type 2 Diabetes db\/db Mice"],"prefix":"10.1155","volume":"2021","author":[{"given":"Salamet","family":"Edirs","sequence":"first","affiliation":[{"name":"The Key Laboratory of Plant Resources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, 40-1 Beijing Road, Urumqi, Xinjiang 830011, China"},{"name":"State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, 40-1 Beijing Road, Urumqi, Xinjiang 830011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Jiang","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Plant Resources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, 40-1 Beijing Road, Urumqi, Xinjiang 830011, China"},{"name":"State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, 40-1 Beijing Road, Urumqi, Xinjiang 830011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6009-2996","authenticated-orcid":true,"given":"XueLei","family":"Xin","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Plant Resources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, 40-1 Beijing Road, Urumqi, Xinjiang 830011, China"},{"name":"State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, 40-1 Beijing Road, Urumqi, Xinjiang 830011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4652-6879","authenticated-orcid":true,"given":"Haji Akber","family":"Aisa","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Plant Resources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, 40-1 Beijing Road, Urumqi, Xinjiang 830011, China"},{"name":"State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, 40-1 Beijing Road, Urumqi, Xinjiang 830011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2011.07.010"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.2337\/dc06-1834"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1210\/er.2007-0015"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2330"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v23.i43.7657"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2199"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m110636200"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2007.04.045"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m111.228817"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2015.08.001"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-014-2152-x"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.fshw.2020.04.005"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.fshw.2020.02.002"},{"key":"14","volume-title":"Avicenna Medical","author":"M. 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