{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T13:12:09Z","timestamp":1771333929334,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,12,14]],"date-time":"2021-12-14T00:00:00Z","timestamp":1639440000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Healthcare Engineering"],"published-print":{"date-parts":[[2021,12,14]]},"abstract":"<jats:p>Objective. To explore the correlation between parturients\u2019 uterine artery blood flow spectra in the first and second trimesters of pregnancy and fetal growth restriction (FGR). Methods. The data of parturients treated in our hospital from February 2018 to February 2020 were retrospectively analyzed, 50 parturients with FGR were selected as the FGR group, and other 50 healthy cases were selected as the control group. In the first trimester (11-12\u2009weeks of gestation) and the second trimester of pregnancy (13\u201324 weeks of gestation), the parturients of the two groups accepted the color Doppler ultrasonography (CDS), their hemodynamics indicators of uterine artery were recorded, and the correlation between their uterine artery blood flow spectra in the two periods and FGR was analyzed with the Receiver Operating Characteristic (ROC) curve. Results. No statistical differences in the parturients\u2019 general information including age, gestational weeks, gravidity, and parity between the two groups were observed (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                     <\/a:math>\n                  <\/jats:inline-formula>\u2009&gt;\u20090.05); the newborn\u2019s body weight, Apgar scores, number of preterm infants, and the number of infants transferring to the neonatal intensive care unit (NICU) were significantly different between the two groups (<jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>P<\/c:mi>\n                     <\/c:math>\n                  <\/jats:inline-formula>\u2009&lt;\u20090.05); in the first and second trimesters of pregnancy, the uterine artery pulsatility index (UtA-PI), uterine artery resistance index (UtA-RI), maximal systolic flow velocity, and systolic\/diastolic (UtA-S\/D) ratio were significantly higher in the FGR group than in the control group (<jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>P<\/e:mi>\n                     <\/e:math>\n                  <\/jats:inline-formula>\u2009&lt;\u20090.05), and the time-averaged maximal velocity (TAMX) was significantly lower in the FGR group than in the control group (<jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>P<\/g:mi>\n                     <\/g:math>\n                  <\/jats:inline-formula>\u2009&lt;\u20090.001); in early pregnancy, the incidence of early diastolic notch at bilateral uterine arteries between the two groups was not significantly different (<jats:inline-formula>\n                     <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <i:mi>P<\/i:mi>\n                     <\/i:math>\n                  <\/jats:inline-formula>\u2009&gt;\u20090.05), and the unilateral and total incidence in the first trimester as well as the unilateral, bilateral, and total incidence in the second trimester were significantly higher in the FGR group than in the control group (<jats:inline-formula>\n                     <k:math xmlns:k=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\">\n                        <k:mi>P<\/k:mi>\n                     <\/k:math>\n                  <\/jats:inline-formula>\u2009&lt;\u20090.05); in the first trimester, the sensitivity of detecting FGR with a uterine artery blood flow spectrum was 0.820, AUC (95% CI)\u2009=\u20090.840 (0.757\u20130.923), and in the second trimester, it was 0.860, AUC (95% CI)\u2009=\u20090.900 (0.832\u20130.968). Conclusion. There is a correlation between uterine artery blood flow spectra in the first and second trimesters of pregnancy and FGR, and the sensitivity of spectrum in the first trimester is higher than that in the second trimester, presenting a better clinical application value.<\/jats:p>","DOI":"10.1155\/2021\/2129201","type":"journal-article","created":{"date-parts":[[2021,12,15]],"date-time":"2021-12-15T02:35:09Z","timestamp":1639535709000},"page":"1-8","source":"Crossref","is-referenced-by-count":3,"title":["Correlation between Parturients\u2019 Uterine Artery Blood Flow Spectra in the First and Second Trimesters of Pregnancy and Fetal Growth Restriction"],"prefix":"10.1155","volume":"2021","author":[{"given":"Hongna","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Ultrasound, Yantai Yuhuangding Hospital, Yantai, 264000, Shandong Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meiqin","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Yantai Yuhuangding Hospital, Yantai, 264000, Shandong Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Yantai Yuhuangding Hospital, Yantai, 264000, Shandong Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xia","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Yantai Yuhuangding Hospital, Yantai, 264000, Shandong Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2236-1996","authenticated-orcid":true,"given":"Meiping","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Yantai Yuhuangding Hospital, Yantai, 264000, Shandong 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