{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T04:56:49Z","timestamp":1780635409297,"version":"3.54.1"},"reference-count":29,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,9,14]],"date-time":"2021-09-14T00:00:00Z","timestamp":1631577600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Basic and Clinical Research on Early Diagnosis of Thyroid Tumors in Zhangjiakou Area","award":["361009-3"],"award-info":[{"award-number":["361009-3"]}]},{"name":"Basic and Clinical Research on Early Diagnosis of Thyroid Tumors in Zhangjiakou Area","award":["{2020}397"],"award-info":[{"award-number":["{2020}397"]}]},{"name":"Hebei Provincial Government","award":["361009-3"],"award-info":[{"award-number":["361009-3"]}]},{"name":"Hebei Provincial Government","award":["{2020}397"],"award-info":[{"award-number":["{2020}397"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2021,9,14]]},"abstract":"<jats:p>Objectives. Abnormal expression of trefoil factor 3 (TFF3) in breast, stomach, and colon tumors may be related to the occurrence of tumors, suggesting its role in angiogenesis. In this study, the aim was to explore the role of TFF3 in thyroid cancer. Methods. TFF3 expression analysis was performed via GEPIA and RT-PCR. To explore the effects of TFF3 on thyroid cancer cell motility, cell function assays were performed. Furthermore, GSEA pathway analysis and western blot were used to explore the mechanism by which TFF3 represses the progression of thyroid cancer cells. Results. Here, we showed that low expression level of TFF3 in thyroid cancer is related to thyroid cancer nodal metastasis. The patients with low TFF3 expression showed worse disease-free survival than those with high level of TFF3. Underexpressed TFF3 increased cell motility and inhibited cell apoptosis. We found that the levels of IL-6, p-JAK2\/JAK2, and pSTAT3\/STAT3 were inhibited in the pcDNA-TFF3 group compared to the pcDNA-NC group and these factors were upregulated in the si-TFF3 group compared to the si-NC group in BCPAP and TPC-1 cells. Conclusion. TFF3 inhibits thyroid cancer cell progression related to IL-6\/JAK\/STAT3 signaling pathway.<\/jats:p>","DOI":"10.1155\/2021\/2130229","type":"journal-article","created":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T18:16:59Z","timestamp":1631729819000},"page":"1-11","source":"Crossref","is-referenced-by-count":11,"title":["Trefoil Factor 3 Inhibits Thyroid Cancer Cell Progression Related to IL-6\/JAK\/STAT3 Signaling Pathway"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3797-440X","authenticated-orcid":true,"given":"Yunchao","family":"Xin","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of Hebei North University, Zhangjiakou, Hebei 075000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9831-0781","authenticated-orcid":true,"given":"Xiaoling","family":"Shang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of Hebei North University, Zhangjiakou, Hebei 075000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7329-6859","authenticated-orcid":true,"given":"Xiaoran","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The First Affiliated Hospital of Hebei North University, Zhangjiakou, Hebei 075000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8364-1775","authenticated-orcid":true,"given":"Yachao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of Hebei North University, Zhangjiakou, Hebei 075000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7459-7741","authenticated-orcid":true,"given":"Guogang","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of Hebei North University, Zhangjiakou, Hebei 075000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3776-0009","authenticated-orcid":true,"given":"Gang","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of Hebei North University, Zhangjiakou, Hebei 075000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2008.0152"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2012.0520"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/542358"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m101363200"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.26332\/seemedj.v4i2.143"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-014-2933-6"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.14670\/HH-22.743"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1111\/nep.12746"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1186\/1478-811x-10-41"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0074670"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m114.564252"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.3892\/or.2014.3514"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2016.01052"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1114885"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.neo.2017.05.002"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkz430"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506580102"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.86.7.7653"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.2174\/138920207783406460"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.3233\/cbm-160147"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.5500"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2005.08.016"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2011.02.003"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1083\/jcb1861oia2"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1275"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2012.04.007"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1201232109"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2015.2409"},{"key":"29","first-page":"1265","article-title":"[Relationship between activated STAT3 protein and epithelial-mesenchymal transition in papillary thyroid carcinoma]","volume":"27","author":"Z. 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