{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:39:43Z","timestamp":1747190383328,"version":"3.40.5"},"reference-count":21,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,10,12]],"date-time":"2021-10-12T00:00:00Z","timestamp":1633996800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2021,10,12]]},"abstract":"<jats:p>In the current study, a Cu(II) coordination polymer (CP) has been created in success with the solvothermal reaction between an asymmetrical rigid N-heterocyclic carboxylatic acid (HL) and Cu(NO3)2\u00b73H2O in the existence of 1,3-H2bdc, the second assistant ligand (in which 1,3-H2bdc is benzene-1,3-dicarboxylic acid and HL is 1-(4-carboxylphenyl)-3-(prazin-2-yl)-1H-1,2,4-triazole), and the chemical composition of this compound is [Cu2(L)2(1,3-bdc)(H2O)2]n (1). In the biological aspect, we screened the antiproliferation activity of the Cu(II) coordination polymer on five kinds of human cancer cell lines. IC50 and MTT assay results indicated that complex 1 had a spectral antiproliferative activity against liver cancer cells, peculiarly on human HepG2 liver cancer cells. From the data of Annexin V-FITC\/PI assay and ROS detection, we can find that complex 1 exerts an antitumor effect by inducing ROS generation and cell apoptosis. Caspase-3 and caspase-9 activity detection revealed that activation of caspase-3 and caspase-9 plays vital roles in HepG2 cell apoptosis. These outcomes indicate that 1 is an excellent compound in treating cancer.<\/jats:p>","DOI":"10.1155\/2021\/2174290","type":"journal-article","created":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T01:46:28Z","timestamp":1634089588000},"page":"1-8","source":"Crossref","is-referenced-by-count":0,"title":["Cu(II) Coordination Polymer Inhibits Liver Cancer Development via Targeting BCL-2 Protein and Activating Apoptotic Pathway"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2453-6470","authenticated-orcid":true,"given":"Jing","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery, Wuhan Central Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4137-5274","authenticated-orcid":true,"given":"Xiaowen","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery, Wuhan Central Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1061-2161","authenticated-orcid":true,"given":"Xuejiao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery, Wuhan Central Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8084-338X","authenticated-orcid":true,"given":"Xiaoyu","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery, Wuhan Central Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"doi-asserted-by":"publisher","key":"1","DOI":"10.1016\/j.bbcan.2019.188314"},{"issue":"7","key":"2","first-page":"787","article-title":"Liver cancer","volume":"64","author":"T. Yamashita","year":"2016","journal-title":"Rinsho Byori"},{"doi-asserted-by":"publisher","key":"3","DOI":"10.1016\/j.poly.2013.04.010"},{"doi-asserted-by":"publisher","key":"4","DOI":"10.1016\/j.molliq.2021.115844"},{"doi-asserted-by":"publisher","key":"5","DOI":"10.1002\/aoc.5373"},{"doi-asserted-by":"publisher","key":"6","DOI":"10.1016\/j.ccr.2019.02.021"},{"doi-asserted-by":"publisher","key":"7","DOI":"10.1016\/j.micromeso.2017.07.057"},{"doi-asserted-by":"publisher","key":"8","DOI":"10.1002\/cplu.202000584"},{"doi-asserted-by":"publisher","key":"9","DOI":"10.1016\/j.saa.2021.120232"},{"doi-asserted-by":"publisher","key":"10","DOI":"10.1016\/j.micromeso.2021.111396"},{"doi-asserted-by":"publisher","key":"11","DOI":"10.1021\/acs.cgd.1c00479"},{"doi-asserted-by":"publisher","key":"12","DOI":"10.1002\/anie.201603934"},{"doi-asserted-by":"publisher","key":"13","DOI":"10.1021\/acs.inorgchem.8b00237"},{"doi-asserted-by":"publisher","key":"14","DOI":"10.1016\/j.poly.2018.05.050"},{"doi-asserted-by":"publisher","key":"15","DOI":"10.1021\/cg401599x"},{"doi-asserted-by":"publisher","key":"16","DOI":"10.1016\/j.jssc.2017.04.005"},{"doi-asserted-by":"publisher","key":"17","DOI":"10.3390\/polym10020165"},{"doi-asserted-by":"publisher","key":"18","DOI":"10.1177\/1934578X1701200522"},{"doi-asserted-by":"publisher","key":"19","DOI":"10.3892\/etm.2018.6388"},{"doi-asserted-by":"publisher","key":"20","DOI":"10.2174\/1871520614666140209144042"},{"doi-asserted-by":"publisher","key":"21","DOI":"10.2147\/OTT.S157715"}],"container-title":["Disease Markers"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2021\/2174290.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2021\/2174290.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2021\/2174290.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T16:57:15Z","timestamp":1646240235000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/dm\/2021\/2174290\/"}},"subtitle":[],"editor":[{"given":"Nashwa","family":"El-Khazragy","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2021,10,12]]},"references-count":21,"alternative-id":["2174290","2174290"],"URL":"https:\/\/doi.org\/10.1155\/2021\/2174290","relation":{},"ISSN":["1875-8630","0278-0240"],"issn-type":[{"type":"electronic","value":"1875-8630"},{"type":"print","value":"0278-0240"}],"subject":[],"published":{"date-parts":[[2021,10,12]]}}}