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Severe oral mucositis may cause unwanted interruption in radiotherapy and reduce long\u2010term survival in cancer patients receiving radiotherapy, but until now, there have been no effective options for preventing radiation\u2010induced oral mucositis. Quercetin is a flavonoid that is widely found in food species and has anti\u2010inflammatory, antioxidant, and anticancer activities. In this study, we investigated a new role of quercetin in preventing radiation\u2010induced oral mucositis. Quercetin exerted preventive effects against radiation\u2010induced oral mucositis induced by single\u2010dose (25\u2009Gy) ionizing radiation or fractionated ionizing radiation (8\u2009Gy \u00d7 3) in C57BL\/6 mice and maintained the proliferation ability of basal epithelial cells. Quercetin pretreatment alleviated reactive oxygen species generation, NF\u2010<jats:italic>\u03ba<\/jats:italic>B pathway activation, and downstream proinflammatory cytokine production and reduced DNA double\u2010strand breaks and cellular senescence induced by ionizing radiation. Quercetin also upregulated BMI\u20101 expression in oral epithelial cells and promoted ulcer repair. In addition, quercetin exerted similar radioprotective effects in irradiated primary cultured normal human keratinocytes, reduced reactive oxygen species generation and proinflammatory cytokine release, and promoted DNA double\u2010strand break repair and wound healing by upregulating the expression of BMI\u20101, which is a polycomb group protein. Thus, quercetin can block multiple pathological processes of radiation\u2010induced oral mucositis by targeting BMI\u20101 and may be a potential treatment option for preventing radiation\u2010induced oral mucositis.<\/jats:p>","DOI":"10.1155\/2021\/2231680","type":"journal-article","created":{"date-parts":[[2021,11,27]],"date-time":"2021-11-27T20:50:09Z","timestamp":1638046209000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["[Retracted] Quercetin Prevents Radiation\u2010Induced Oral Mucositis by Upregulating 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