{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:39:59Z","timestamp":1747190399047,"version":"3.40.5"},"reference-count":8,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,11,28]],"date-time":"2021-11-28T00:00:00Z","timestamp":1638057600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Cardiology"],"published-print":{"date-parts":[[2021,11,28]]},"abstract":"<jats:p>Background. Chylopericardium is the accumulation of lymphatic fluid in the pericardial cavity. It can be idiopathic or secondary to trauma, cardiothoracic surgery, neoplasm, radiation, tuberculosis, lymphatic duct dysfunction, thrombosis, or other causes. We present a case of chylopericardium due to subclavian vein thrombosis in a patient with protein S deficiency. Clinical Case. A 48-year-old man with a history of protein S deficiency presented to the emergency department with shortness of breath and a productive cough. CT of the chest showed pulmonary emboli, moderate pericardial effusion, and a large thrombus of the superior vena cava, brachiocephalic vein, and subclavian veins. He developed echocardiographic evidence of cardiac tamponade so he underwent pericardiocentesis with drainage of milky-appearing fluid. Analysis of the fluid showed elevated triglycerides consistent with chylopericardium. The pericardial effusion reaccumulated, likely secondary to lymphatic duct obstruction due to his subclavian vein thrombus. Catheter-assisted thrombolysis was performed with resolution of the patient\u2019s effusion and symptoms. Conclusion. Chylopericardium is a rare but important complication of subclavian vein thrombosis. Management is typically with surgical intervention, although our case represents successful treatment with catheter-assisted thrombolysis.<\/jats:p>","DOI":"10.1155\/2021\/2232057","type":"journal-article","created":{"date-parts":[[2021,11,29]],"date-time":"2021-11-29T00:57:40Z","timestamp":1638147460000},"page":"1-4","source":"Crossref","is-referenced-by-count":1,"title":["Chylopericardium due to Subclavian Vein Thrombosis in the Setting of Protein S Deficiency"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1878-1020","authenticated-orcid":true,"given":"Ian","family":"Jackson","sequence":"first","affiliation":[{"name":"Department of Medicine, Creighton University School of Medicine, Omaha, NE, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3538-5938","authenticated-orcid":true,"given":"Yaman","family":"Alali","sequence":"additional","affiliation":[{"name":"Department of Medicine, Creighton University School of Medicine, Omaha, NE, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5061-0702","authenticated-orcid":true,"given":"Abedel Rahman","family":"Anani","sequence":"additional","affiliation":[{"name":"Department of Medicine, Creighton University School of Medicine, Omaha, NE, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7852-6203","authenticated-orcid":true,"given":"Ali","family":"Nayfeh","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care, Creighton University School of Medicine, Omaha, NE, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6097-6257","authenticated-orcid":true,"given":"Arindam","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Creighton University School of Medicine, Omaha, NE, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3021-3977","authenticated-orcid":true,"given":"Abhishek","family":"Thandra","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Creighton University School of Medicine, Omaha, NE, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5540-2635","authenticated-orcid":true,"given":"Amjad","family":"Kabach","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Creighton University School of Medicine, Omaha, NE, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-7940(96)01040-8"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1186\/s12893-015-0047-8"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2008.03.033"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1093\/jscr\/rjw242"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(19)42160-0"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008265816500"},{"issue":"1","key":"7","first-page":"419","article-title":"Primary chylopericardium: a case report and literature review","volume":"15","author":"X. Yu","year":"2018","journal-title":"Experimental and Therapeutic Medicine"},{"key":"8","first-page":"214","article-title":"Secondary chylopericardium complicated with cardiac tamponade in a drug addict: a case report","volume":"15","author":"C.-M. Chen","year":"2004","journal-title":"Journal of Internal Medicine of Taiwan"}],"container-title":["Case Reports in Cardiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cric\/2021\/2232057.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cric\/2021\/2232057.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cric\/2021\/2232057.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,29]],"date-time":"2021-11-29T00:57:43Z","timestamp":1638147463000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/cric\/2021\/2232057\/"}},"subtitle":[],"editor":[{"given":"Ertugurul","family":"Ercan","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2021,11,28]]},"references-count":8,"alternative-id":["2232057","2232057"],"URL":"https:\/\/doi.org\/10.1155\/2021\/2232057","relation":{},"ISSN":["2090-6412","2090-6404"],"issn-type":[{"type":"electronic","value":"2090-6412"},{"type":"print","value":"2090-6404"}],"subject":[],"published":{"date-parts":[[2021,11,28]]}}}