{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:40:08Z","timestamp":1747190408921,"version":"3.40.5"},"reference-count":25,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,11,26]],"date-time":"2021-11-26T00:00:00Z","timestamp":1637884800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parkinson's Disease"],"published-print":{"date-parts":[[2021,11,26]]},"abstract":"<jats:p>Background. Autonomic dysfunctions occur in the early stage of Parkinson\u2019s disease (PD) and impact the quality of life during the progression of the disease. In this study, we evaluated the serial progression of autonomic dysfunctions between different subtypes of a prospective PD cohort. Materials and Methods. From the Parkinson\u2019s Progression Markers Initiative (PPMI) database, 325 PD patients (age: 61.2\u2009\u00b1\u20099.7, M\u2009:\u2009F\u2009=\u2009215\u2009:\u2009110) were enrolled. Patients were subgrouped into tremor-dominant (TD), indeterminate, and postural instability and gait disorder (PIGD) subtypes. The progression of autonomic dysfunctions and dopaminergic denervation from I-123 FP-CIT SPECT images of each group were analyzed and compared at baseline, 12 months, 24 months, and 48 months of follow-up periods. Results. The SCOPA-AUT score of the indeterminate subtype was significantly higher than that of the TD subtype (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>&lt;<\/a:mo>\n                        <a:mn>0.05<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>) at baseline and was significantly higher than that of both TD and PIGD subtypes (<jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>P<\/c:mi>\n                        <c:mo>&lt;<\/c:mo>\n                        <c:mn>0.05<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>) at 48 months. The indeterminate subtype had the most significant correlation between the aggravation of dopaminergic denervation in I-123 FP-CIT SPECT images and the increase of SCOPA-AUT scores during 48 months of follow-up (r\u2009=\u20090.56, <jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>P<\/e:mi>\n                        <e:mo>&lt;<\/e:mo>\n                        <e:mn>0.01<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula>). Conclusions. Autonomic dysfunctions were most severe in the indeterminate subtype throughout the 48 months of the follow-up period, with a significant correlation with dopaminergic denervation. We suggest a positive relationship between dopaminergic denervation and autonomic dysfunctions of the indeterminate subtype, beginning from the early stage of PD.<\/jats:p>","DOI":"10.1155\/2021\/2268651","type":"journal-article","created":{"date-parts":[[2021,11,26]],"date-time":"2021-11-26T23:20:07Z","timestamp":1637968807000},"page":"1-5","source":"Crossref","is-referenced-by-count":5,"title":["Correlation of Dopaminergic Denervation and the Progression of Autonomic Dysfunctions in Different Clinical Subtypes of Parkinson\u2019s Disease"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4494-4762","authenticated-orcid":true,"given":"Eun Hye","family":"Jeong","sequence":"first","affiliation":[{"name":"Bundang Jesaeng Hospital, Department of Neurology, Seongnam, Gyeonggido, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mun Kyung","family":"Sunwoo","sequence":"additional","affiliation":[{"name":"Bundang Jesaeng Hospital, Department of Neurology, Seongnam, Gyeonggido, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Wook","family":"Hyung","sequence":"additional","affiliation":[{"name":"Bundang Jesaeng Hospital, Department of Neurology, Seongnam, Gyeonggido, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sun-Ku","family":"Han","sequence":"additional","affiliation":[{"name":"Bundang Jesaeng Hospital, Department of Neurology, Seongnam, Gyeonggido, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Yong","family":"Lee","sequence":"additional","affiliation":[{"name":"Bundang Jesaeng Hospital, Department of Neurology, Seongnam, Gyeonggido, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2008.02056.x"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2007.131045"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1007\/s11940-003-0005-0"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2009.08.007"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2013.12.001"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-015-0306-x"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25383"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26510"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23387"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-014-1349-1"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23346"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20996"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2015.0703"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awx118"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2016.04.026"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/s0197-4580(02)00065-9"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20321"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2011.09.030"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27186"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2990.2006.00727.x"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2008.02057.x"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000138500.73671.dc"},{"issue":"10","key":"23","first-page":"1694","article-title":"Loss of dopamine transporter binding in Parkinson\u2019s disease follows a single exponential rather than linear decline","volume":"45","author":"J. 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