{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T07:52:18Z","timestamp":1767167538375,"version":"build-2238731810"},"reference-count":17,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T00:00:00Z","timestamp":1635465600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Chongqing Natural Science Fund","award":["cstc2020jcyj-msxmX0404"],"award-info":[{"award-number":["cstc2020jcyj-msxmX0404"]}]},{"name":"Chongqing Natural Science Fund","award":["cstc2018jxj1130016"],"award-info":[{"award-number":["cstc2018jxj1130016"]}]},{"name":"Performance Incentive and Guidance Project of Chongqing Research Institutions","award":["cstc2020jcyj-msxmX0404"],"award-info":[{"award-number":["cstc2020jcyj-msxmX0404"]}]},{"name":"Performance Incentive and Guidance Project of Chongqing Research Institutions","award":["cstc2018jxj1130016"],"award-info":[{"award-number":["cstc2018jxj1130016"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Healthcare Engineering"],"published-print":{"date-parts":[[2021,10,29]]},"abstract":"<jats:p>\n                    Objective. To analyze the clinical incidence, clinical manifestations, laboratory examination, and complications of Sjogren\u2019s syndrome complicated with thyroid disorders in patients and to explore the clinical significance of its occurrence and concurrence relationship. Methods. The clinical manifestations, thyroid function, antithyroid antibodies, immunology indicators, autoantibodies, and routine laboratory examination items of 201 patients with Sjogren\u2019s syndrome in Chongqing Hospital of Traditional Chinese Medicine were reviewed and analyzed. According to whether the thyroid function was abnormal or not, the patients were divided into the group of Sjogren\u2019s syndrome complicated with abnormal thyroid function (n\u2009=\u200936) and the group of Sjogren\u2019s syndrome without abnormal thyroid function (n\u2009=\u2009165). The clinical symptoms and test indicators of the two groups were compared. Results. Among 201 patients with Sjogren\u2019s syndrome, 36 patients had abnormal thyroid function (17.9%) and 36 patients with abnormal thyroid function had hypothyroidism. The abnormal renal function, decreased Hb, decreased WBC, increased ESR, and decreased C4 were more significant in the group with Sjogren\u2019s syndrome complicated with abnormal thyroid function, which had significant differences compared with the group with normal thyroid function (\n                    <jats:inline-formula>\n                      <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>&lt;<\/a:mo>\n                        <a:mn>0.05<\/a:mn>\n                      <\/a:math>\n                    <\/jats:inline-formula>\n                    ). The positive rates of aTG and aTPO in patients with Sjogren\u2019s syndrome complicated with thyroid disorders were higher than that in the normal group, and the difference between the two groups was statistically significant (\n                    <jats:inline-formula>\n                      <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>P<\/c:mi>\n                        <c:mo>&lt;<\/c:mo>\n                        <c:mn>0.05<\/c:mn>\n                      <\/c:math>\n                    <\/jats:inline-formula>\n                    ). Conclusion. Patients with Sjogren\u2019s syndrome are often associated with hypothyroidism, and these patients may have more severe immune disorders, anemia, leukopenia, and renal involvement. The results show that paying attention to the detection of thyroid function in patients with Sjogren\u2019s syndrome may be of positive significance to judge the condition and prognosis.\n                  <\/jats:p>","DOI":"10.1155\/2021\/2280070","type":"journal-article","created":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T15:35:09Z","timestamp":1635521709000},"page":"1-5","source":"Crossref","is-referenced-by-count":5,"title":["Clinical Features and Laboratory Examination Results of Sjogren\u2019s Syndrome Complicated with Thyroid Disorders: A Retrospective Analysis"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9221-4492","authenticated-orcid":true,"given":"Min","family":"Dai","sequence":"first","affiliation":[{"name":"Chongqing Hospital of Traditional Chinese Medicine, Chongqing 400021, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1107-1421","authenticated-orcid":true,"given":"Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"Chongqing Hospital of Traditional Chinese Medicine, Chongqing 400021, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7920-8039","authenticated-orcid":true,"given":"Qian","family":"Huang","sequence":"additional","affiliation":[{"name":"Chongqing City Management College, Chongqing 401331, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmcp1702514"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.6737"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1136\/ard.61.6.554"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.5114\/ceji.2016.63130"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.11535.1"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2016.03.005"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00121"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2012.05.008"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-007-0638-6"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/254319"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.2174\/1573397112666160714164149"},{"issue":"12","key":"12","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1002\/art.1780341218","article-title":"Autoimmunity to human thyroglobulin. 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