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Atopic dermatitis is a chronic inflammatory skin disease. Lagerstroemia ovalifolia Teijsm. &amp; Binn. (LO) has traditionally been used as an herbal medicine for anti-inflammatory diseases. The effect of LO on atopic dermatitis has not been verified scientifically. We investigated the effects of CHCl3 fraction number 5 of LO (LOC) on atopic dermatitis through cell-based experiments. HaCaT cells were treated with tumor necrosis factor-alpha (TNF\u03b1)\/interferon-gamma (IFN\u03b3) to induce an inflammatory reaction. Proinflammatory cytokines, interleukin- (IL-) 6, IL-8, and IL-1\u03b2 and chemokines such as thymus and activation-regulated chemokine (TARC\/CCL17), monocyte chemoattractant protein 1 (MCP1\/CCL2), and macrophage-derived chemokine (MDC\/CCL22) were measured by RT-PCR and ELISA. In addition, the degree of phosphorylation and activation of JAK\/STAT1, PI3K\/AKT, and nuclear factor-kappa B (NF-\u03baB) were measured by western blot and luciferase assays. The production of inflammatory cytokines and chemokines and activation of the JAK\/STAT1, PI3K\/AKT, and NF-\u03baB pathways were induced by TNF\u03b1\/IFN\u03b3 in HaCaT cells. Under these conditions, LOC treatment inhibited the production of targeted cytokines and chemokines and decreased the phosphorylation and activation of JAK\/STAT1, PI3K\/AKT, and NF-\u03baB. These results suggest that LOC reduces the production of proinflammatory cytokines and chemokines by suppressing the JAK\/STAT1, PI3K\/AKT, and NF-\u03baB pathways. Therefore, LOC may have potential as a drug for atopic dermatitis.<\/jats:p>","DOI":"10.1155\/2021\/2439231","type":"journal-article","created":{"date-parts":[[2021,11,9]],"date-time":"2021-11-09T23:20:09Z","timestamp":1636500009000},"page":"1-10","source":"Crossref","is-referenced-by-count":6,"title":["Anti-Inflammatory Effects of Lagerstroemia ovalifolia Teijsm. &amp; Binn. in TNF\u03b1\/IFN\u03b3-Stimulated Keratinocytes"],"prefix":"10.1155","volume":"2021","author":[{"given":"Han-Sol","family":"Lee","sequence":"first","affiliation":[{"name":"Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, 30 Yeongudanji-ro, Ochang-eup, Cheongwon-gu, Cheongju-si, Chungcheongbuk-do 28116, Republic of Korea"},{"name":"College of Pharmacy, Chungbuk National University, Osongsaengmyeong 1-ro, Osong-eup, Heungdeok-gu, Cheongju-si, Chungcheongbuk-do 28160, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-Hyub","family":"Paik","sequence":"additional","affiliation":[{"name":"International Biological Material Research Center, Korea Research Institute of Bioscience and Biotechnology, 111 Gwahangno, Yuseong-gu, Daejeon 305-806, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9219-5535","authenticated-orcid":true,"given":"Ok-Kyoung","family":"Kwon","sequence":"additional","affiliation":[{"name":"Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, 30 Yeongudanji-ro, Ochang-eup, Cheongwon-gu, Cheongju-si, Chungcheongbuk-do 28116, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Imam","family":"Paryanto","sequence":"additional","affiliation":[{"name":"Center for Pharmaceutical and Medical Technology, Deputy for Agroindustrial Technology and Biotechnology, The Agency for the Assessment and Application of Technology (BPPT), Jalan M.H. 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