{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T17:10:39Z","timestamp":1771261839721,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,9,4]],"date-time":"2021-09-04T00:00:00Z","timestamp":1630713600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2021,9,4]]},"abstract":"<jats:p>Background. Hypertrophic scar (HS) is a benign fibroproliferative skin disease resulting from an aberrant wound healing process and can cause aesthetic and functional damage to patients. Currently, there is no ideal treatment to treat this disease. Galangin, a natural active bioflavonoid compound, is suggested to inhibit fibrosis and proliferation in certain cells. Methods. In this study, we found Galangin could attenuate abnormal scar formation in an HS rabbit ear model. Additionally, the HE staining shows Galangin reduced scar elevation index (SEI) and Masson\u2019s trichrome staining changed collagen deposition. Results. The expressions of type I collagen, type III collagen, and TGF-\u03b21 were much lower under a proper dose of Galangin treatment, and Smad7 expression was also enhanced, which are examined by real-time PCR, immunohistochemistry, and western blot. Conclusion. Our data indicated that Galangin can alleviate dermal scarring via the TGF-\u03b2\/Smad signaling pathway probably by upregulating Smad 7 expression and, thus, suppressing the expression of type I and type III collagens and TGF-\u03b21.<\/jats:p>","DOI":"10.1155\/2021\/2444839","type":"journal-article","created":{"date-parts":[[2021,9,4]],"date-time":"2021-09-04T19:05:06Z","timestamp":1630782306000},"page":"1-10","source":"Crossref","is-referenced-by-count":16,"title":["Bioflavonoid Galangin Suppresses Hypertrophic Scar Formation by the TGF-\u03b2\/Smad Signaling Pathway"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4918-2402","authenticated-orcid":true,"given":"Zha","family":"Ru","sequence":"first","affiliation":[{"name":"Department of Plastic Surgery, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5115-9420","authenticated-orcid":true,"given":"Ying","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7139-5527","authenticated-orcid":true,"given":"Shenghua","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5603-9949","authenticated-orcid":true,"given":"Li","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8298-9198","authenticated-orcid":true,"given":"Kun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5316-4805","authenticated-orcid":true,"given":"Yue","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07039"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1159\/000454919"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2015.11.015"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1097\/prs.0000000000001889"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.suc.2014.05.005"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(16)31406-4"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.2302\/kjm.2011-0002-ir"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.3390\/cells8060607"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475x.2007.00219.x"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2008.06.020"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.10.059"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.3892\/or.2016.5224"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/s0024-3205(03)00232-7"},{"issue":"3","key":"14","first-page":"2442","article-title":"Quercetin is able to alleviate TGF-beta-induced fibrosis in renal tubular epithelial cells by suppressing miR-21","volume":"16","author":"Y. 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