{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T08:08:02Z","timestamp":1767168482345,"version":"build-2238731810"},"reference-count":20,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T00:00:00Z","timestamp":1634774400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2021,10,21]]},"abstract":"<jats:p>\n                    Objective. To evaluate the value of the Alberta stroke project early CT score (ASPECTS), DRAGON score, SEDAN score, and HAT score in predicting hemorrhagic transformation (HT) after intravenous thrombolysis in patients with acute ischemic stroke (AIS). Methods. The clinical data of 248 AIS patients treated with intravenous thrombolysis in our hospital from December 2017 to December 2019 were analyzed. According to the prognosis, all patients were divided into the non-HT group (n\u2009=\u2009200) and the HT group (n\u2009=\u200948). Univariate analysis and multivariate logistic regression models were used to analyze clinical data to determine the influencing factors of HT after intravenous thrombolysis in AIS patients. The receiver operating characteristic curve was used to evaluate the ASPECTS, DRAGON, SEDAN, and HAT scores to the value of predicting HT after intravenous thrombolysis in AIS patients. Results. The lower the ASPECTS score and the higher the DRAGON, SEDAN, and HAT scores, the higher the incidence of HT after intravenous thrombolysis in AIS patients (\n                    <jats:inline-formula>\n                      <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>&lt;<\/a:mo>\n                        <a:mn>0.05<\/a:mn>\n                      <\/a:math>\n                    <\/jats:inline-formula>\n                    ). The results of multivariate logistic regression analysis showed that the patient\u2019s age, atrial fibrillation, baseline NIHSS score, early signs of infarction on admission with head CT, time from onset to thrombolytic therapy, and thrombolytic drugs were all independent factors affecting intravenous thrombolysis in AIS patients (\n                    <jats:inline-formula>\n                      <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>P<\/c:mi>\n                        <c:mo>&lt;<\/c:mo>\n                        <c:mn>0.05<\/c:mn>\n                      <\/c:math>\n                    <\/jats:inline-formula>\n                    ). The area under the curve (AUC) of the predictive value of ASPECTS for HT is 0.895 (95% CI 0.813\u20130.977). When the optimal cutoff value is 0.607, the sensitivity is 100% and the specificity is 60.7%. The AUC of the predictive value of DRAGON for HT is 0.877 (95% CI 0.790\u20130.964). When the optimal cutoff value is 0.665, the sensitivity is 84.4% and the specificity is 82.1%. The AUC of the predictive value of SEDAN for HT is 0.764 (95% CI 0.638\u20130.890). When the optimal cutoff value is 0.474, the sensitivity is 78.6% and the specificity is 68.8%. The AUC of the predictive value of HAT for HT is 0.777 (95% CI 0.651\u20130.903). When the optimal cutoff value is 0.509, the sensitivity is 68.8% and the specificity is 82.1%. Conclusion. The lower the ASPECTS score and the higher the DRAGON, SEDAN, and HAT scores, the higher the incidence of HT in AIS patients. The patient\u2019s age, atrial fibrillation, baseline NIHSS score, early signs of infarction on admission with head CT, time from onset to thrombolytic therapy, and thrombolytic drugs are all independent factors affecting HT in AIS patients. The scores of ASPECTS, DRAGON, SEDAN and HAT have certain value in predicting HT after intravenous thrombolysis in AIS patients, and the predicted value of ASPECTS score is the best.\n                  <\/jats:p>","DOI":"10.1155\/2021\/2468052","type":"journal-article","created":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T13:07:13Z","timestamp":1634821633000},"page":"1-7","source":"Crossref","is-referenced-by-count":7,"title":["Different Scores Predict the Value of Hemorrhagic Transformation after Intravenous Thrombolysis in Patients with Acute Ischemic Stroke"],"prefix":"10.1155","volume":"2021","author":[{"given":"Xiaozan","family":"Chang","sequence":"first","affiliation":[{"name":"Neurosurgery Department of Stroke Center, Henan Provincial People\u2019s Hospital, Zhengzhou, China"},{"name":"Cerebrovascular Department of Interventional Center, Zhengzhou University People\u2019s Hospital, Zhengzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoxi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Stroke Center, Naval Medical University First Affiliated Hospital, Shanghai 200433, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7248-4874","authenticated-orcid":true,"given":"Guanglin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Neurosurgery Department of Stroke Center, Henan Provincial People\u2019s Hospital, Zhengzhou, China"},{"name":"Cerebrovascular Department of Interventional Center, Zhengzhou University People\u2019s Hospital, Zhengzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1097\/ccm.0000000000004597"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1177\/0284185119887593"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1080\/00207454.2017.1349766"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.118.021961"},{"issue":"3","key":"5","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1136\/neurintsurg-2019-015105","article-title":"M. 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