{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T02:46:42Z","timestamp":1746326802739,"version":"3.37.3"},"reference-count":24,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,3,12]],"date-time":"2021-03-12T00:00:00Z","timestamp":1615507200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010843","name":"Guangzhou Science, Technology and Innovation Commission","doi-asserted-by":"publisher","award":["GZ2018ZSF086"],"award-info":[{"award-number":["GZ2018ZSF086"]}],"id":[{"id":"10.13039\/501100010843","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Diabetes Research"],"published-print":{"date-parts":[[2021,3,12]]},"abstract":"<jats:p>Blink reflex provides an objective assessment of the cranial and central nervous systems. However, the relationships between body mass index, dizziness, and BR have not been explored in patients with type 2 diabetes mellitus (T2DM). Moreover, R2 duration, one of the parameters of the blink reflex, has not been studied to date. In the present study, we aimed to investigate the characteristics and influencing factors of blink reflex in patients with T2DM. We included 45 healthy subjects and 105 hospitalized patients with T2DM. The relationships between these parameters and sex, age, body mass index, duration of T2DM, hemoglobin A1c, distal symmetrical polyneuropathy (DSPN), and dizziness symptoms were analyzed. The results showed that blink reflex latencies (including R1, ipsilateral R2, and contralateral R2 latency) were negatively associated with body mass index but were positively correlated with the duration of T2DM. There were no correlations between blink reflex parameters and sex, age, and hemoglobin A1c. Patients with DSPN had longer blink reflex latencies and shorter R2 durations than those without DSPN. Patients with dizziness had longer latencies (including R1, ipsilateral R2, and contralateral R2 latencies) and shorter R2 durations (including ipsilateral R2 and contralateral R2 durations) than those without dizziness. R2 duration was also a predictive factor for blink reflex abnormality. R2 latency was the most sensitive factor and the optimal predictor of dizziness. These results demonstrate that patients with T2DM with low body mass index, longer duration of T2DM, DSPN, and dizziness-related symptoms had more abnormal blink reflex parameters, indicating more serious injuries to the cranial nerves or the central nervous system.<\/jats:p>","DOI":"10.1155\/2021\/2473193","type":"journal-article","created":{"date-parts":[[2021,3,15]],"date-time":"2021-03-15T14:05:45Z","timestamp":1615817145000},"page":"1-7","source":"Crossref","is-referenced-by-count":3,"title":["Changes of Blink Reflex in Type 2 Diabetes Mellitus"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1899-5355","authenticated-orcid":true,"given":"Li","family":"Xiao","sequence":"first","affiliation":[{"name":"Department of Rehabilitation, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, China"},{"name":"Department of Neuroelectrophysiology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kang","family":"Zou","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duoyan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Neuroelectrophysiology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guilan","family":"Ouyang","sequence":"additional","affiliation":[{"name":"Department of Neuroelectrophysiology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuixiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neuroelectrophysiology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3016-0086","authenticated-orcid":true,"given":"Jun","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","volume-title":"Physical Medicine and Rehabilitation","author":"R. 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