{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:41:09Z","timestamp":1747190469424,"version":"3.40.5"},"reference-count":18,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,11,20]],"date-time":"2021-11-20T00:00:00Z","timestamp":1637366400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Cardiology"],"published-print":{"date-parts":[[2021,11,20]]},"abstract":"<jats:p>Acute limb ischemia (ALI) is rarely observed in young populations. The hypercoagulable state is a notable cause of ALI other than artery disease progression and cardiac embolization. A hypercoagulable state occurs in essential thrombocytosis because of the overproduction of hematopoietic cells secondary to the mutation of the JAK2, CALR, or MPL genes. We report a rare case of a 37-year-old woman presenting with Rutherford IIA ALI in the left lower extremity. Laboratory data revealed she had a platelet count reaching up to 1.38\u2009mil\/\u03bcL, with other blood profiles being normal. A JAK2 mutation examination was later performed and proved positive. After careful management with catheter-directed thrombolysis, surgical thrombectomy, and cytoreductive therapy using hydroxyurea, the symptoms subsided and eventually restored the patient to physical activity in less than one month.<\/jats:p>","DOI":"10.1155\/2021\/2563578","type":"journal-article","created":{"date-parts":[[2021,11,20]],"date-time":"2021-11-20T21:50:08Z","timestamp":1637445008000},"page":"1-5","source":"Crossref","is-referenced-by-count":0,"title":["Acute Limb Ischemia in the Young: A Rare Case of Essential Thrombocytosis"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3501-1872","authenticated-orcid":true,"given":"Johanes","family":"Nugroho","sequence":"first","affiliation":[{"name":"Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia"},{"name":"Dr. Soetomo General Hospital, Surabaya, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth","family":"Gunadi","sequence":"additional","affiliation":[{"name":"Dr. Soetomo General Hospital, Surabaya, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.119.039773"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx095"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2017.1.470"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.4032"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-123-9-199511010-00003"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404693"},{"key":"7","first-page":"S36","article-title":"Diagnosis and management of polycythemia vera","volume":"7","author":"L. 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Natelson","year":"2012","journal-title":"Texas Heart Institute Journal"}],"container-title":["Case Reports in Cardiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cric\/2021\/2563578.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cric\/2021\/2563578.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cric\/2021\/2563578.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,20]],"date-time":"2021-11-20T21:50:13Z","timestamp":1637445013000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/cric\/2021\/2563578\/"}},"subtitle":[],"editor":[{"given":"Yigit","family":"Canga","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2021,11,20]]},"references-count":18,"alternative-id":["2563578","2563578"],"URL":"https:\/\/doi.org\/10.1155\/2021\/2563578","relation":{},"ISSN":["2090-6412","2090-6404"],"issn-type":[{"type":"electronic","value":"2090-6412"},{"type":"print","value":"2090-6404"}],"subject":[],"published":{"date-parts":[[2021,11,20]]}}}