{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T01:17:22Z","timestamp":1783214242968,"version":"3.54.6"},"reference-count":55,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,10,8]],"date-time":"2021-10-08T00:00:00Z","timestamp":1633651200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Chengde Science and Technology Planning Project","award":["202006A049"],"award-info":[{"award-number":["202006A049"]}]},{"name":"Chengde Science and Technology Planning Project","award":["202006A088"],"award-info":[{"award-number":["202006A088"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2021,10,8]]},"abstract":"<jats:p>Background. Coronavirus disease 2019 (COVID-19) is highly contagious and continues to spread rapidly. However, there are no simple and timely laboratory techniques to determine the severity of COVID-19. In this meta-analysis, we assessed the potential of the neutrophil-lymphocyte ratio (NLR) as an indicator of severe versus nonsevere COVID-19 cases. Methods. A search for studies on the NLR in severe and nonsevere COVID-19 cases published from January 1, 2020, to July 1, 2021, was conducted on the PubMed, EMBASE, and Cochrane Library databases. The pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio (DOR), and area under the curve (AUC) analyses were done on Stata 14.0 and Meta-disc 1.4 to assess the performance of the NLR. Results. Thirty studies, including 5570 patients, were analyzed. Of these, 1603 and 3967 patients had severe and nonsevere COVID-19, respectively. The overall sensitivity and specificity were 0.82 (95% confidence interval (CI), 0.77-0.87) and 0.77 (95% CI, 0.70-0.83), respectively; positive and negative correlation ratios were 3.6 (95% CI, 2.7-4.7) and 0.23 (95% CI, 0.17-0.30), respectively; DOR was 16 (95% CI, 10-24), and the AUC was 0.87 (95% CI, 0.84-0.90). Conclusion. The NLR could accurately determine the severity of COVID-19 and can be used to identify patients with severe disease to guide clinical decision-making.<\/jats:p>","DOI":"10.1155\/2021\/2571912","type":"journal-article","created":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T04:08:12Z","timestamp":1633925292000},"page":"1-10","source":"Crossref","is-referenced-by-count":35,"title":["Value of the Neutrophil-Lymphocyte Ratio in Predicting COVID-19 Severity: A Meta-analysis"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3463-5667","authenticated-orcid":true,"given":"Ying","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pharmacy, The Affiliated Hospital of Chengde Medical College, Chengde 067000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2418-716X","authenticated-orcid":true,"given":"Jingyi","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Functional Center, Chengde Medical College, Chengde 067000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Yang","sequence":"additional","affiliation":[{"name":"Institute of Chinese Materia Medica, Chengde Medical College, Chengde 067000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhui","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The Affiliated Hospital of Chengde Medical College, Chengde 067000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1244-0930","authenticated-orcid":true,"given":"Yinhui","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The Affiliated Hospital of Chengde Medical College, Chengde 067000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-77698-4"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30211-7"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.33549\/physiolres.934492"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2019.105692"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000000157"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2020.07.026"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.21037\/tp-21-47"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.12122\/j.issn.1673-4254.2020.03.06"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.106504"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.26031"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-020-02374-0"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.23547"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.21037\/atm-20-3391"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.106950"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2020.05.006"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.7150\/thno.45985"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.26300"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268820002071"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.cn121430-20200413-00506"},{"key":"20","first-page":"31","article-title":"Neutrophil to lymphocyte ratio as a prognostic marker in COVID-19","volume":"80","author":"L. 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