{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:41:18Z","timestamp":1747190478337,"version":"3.40.5"},"reference-count":14,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,10,14]],"date-time":"2021-10-14T00:00:00Z","timestamp":1634169600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Hematology"],"published-print":{"date-parts":[[2021,10,14]]},"abstract":"<jats:p>Primary bone marrow diffuse large B-cell lymphoma is an exceedingly rare form of non-Hodgkin lymphoma. It may demonstrate a leukemic presentation, and a proportion of cases have CD5 expression. The prognostic implications of this CD5-positivity remain unknown. Here, we present a 78-year-old man who presented with circulating peripheral blood lymphoma cells and a hypercellular marrow involved by diffuse large B-cell lymphoma, germinal center B-cell subtype. The patient responded favorably to six cycles of etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin, and rituximab (EPOCH-R) and intrathecal methotrexate. He unfortunately relapsed in several enlarged inguinal lymph nodes and succumbed to the lymphoma approximately one year after diagnosis, demonstrating the particularly aggressive clinical course of his disease.<\/jats:p>","DOI":"10.1155\/2021\/2628100","type":"journal-article","created":{"date-parts":[[2021,10,14]],"date-time":"2021-10-14T18:25:56Z","timestamp":1634235956000},"page":"1-3","source":"Crossref","is-referenced-by-count":1,"title":["Aggressive CD5-Positive Primary Bone Marrow Diffuse Large B-Cell Lymphoma with Leukemic Presentation"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9358-9843","authenticated-orcid":true,"given":"Mark G.","family":"Evans","sequence":"first","affiliation":[{"name":"Department of Hematopathology, Division of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4652-2130","authenticated-orcid":true,"given":"Sherif A.","family":"Rezk","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of California Irvine (UCI) Medical Center, Orange, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0919-4951","authenticated-orcid":true,"given":"Lauren C.","family":"Pinter-Brown","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Hematology\/Oncology, University of California Irvine (UCI) Medical Center, Orange, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6921-2787","authenticated-orcid":true,"given":"Xiaohui","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of California Irvine (UCI) Medical Center, Orange, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-010-1129-4"},{"issue":"2","key":"2","first-page":"133","article-title":"Primary bone marrow B-cell lymphoma: report of four cases","volume":"70","author":"J. A. Strauchen","year":"2003","journal-title":"The Mount Sinai Journal of Medicine, New York"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2006.06336.x"},{"issue":"5","key":"4","first-page":"60","article-title":"Bone marrow involvement in malignant lymphoma without peripheral lymphadenopathy","volume":"52","author":"W. G. Staples","year":"1977","journal-title":"South African Medical Journal"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2014.02.010"},{"issue":"4","key":"6","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1080\/10428190310001625746","article-title":"Isolated bone marrow involvement in diffuse large B cell lymphoma: a report of three cases with review of morphological, immunophenotypic and cytogenetic findings","volume":"45","author":"C. L. Alvares","year":"2003","journal-title":"Leukemia and Lymphoma"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.2147\/cmar.s187522"},{"issue":"5","key":"8","first-page":"985","article-title":"Primary hepatosplenic CD5-positive diffuse large B-cell lymphoma: a case report with literature review","volume":"6","author":"X. Zhang","year":"2013","journal-title":"International Journal of Clinical and Experimental Pathology"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1038\/srep20465"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-04-737445"},{"key":"11","first-page":"317","article-title":"Intravascular large B-cell lymphoma","volume-title":"WHO Classification of Tumors of Hematopoietic and Lymphoid Tissues","author":"S. Nakamura","year":"2017","edition":"4th"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1182\/blood.v99.3.815"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2004.19.6.815"},{"issue":"10","key":"14","first-page":"943","article-title":"De novo CD-5 positive diffuse large B-cell lymphoma with leukemic dissemination diagnosed by immunohistochemical examinations of bone marrow clot sections","volume":"43","author":"K. Yoshida","year":"2002","journal-title":"Rinsho Ketsueki"}],"container-title":["Case Reports in Hematology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crihem\/2021\/2628100.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crihem\/2021\/2628100.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crihem\/2021\/2628100.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,14]],"date-time":"2021-10-14T18:26:09Z","timestamp":1634235969000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/crihem\/2021\/2628100\/"}},"subtitle":[],"editor":[{"given":"Pier Paolo","family":"Piccaluga","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2021,10,14]]},"references-count":14,"alternative-id":["2628100","2628100"],"URL":"https:\/\/doi.org\/10.1155\/2021\/2628100","relation":{},"ISSN":["2090-6579","2090-6560"],"issn-type":[{"type":"electronic","value":"2090-6579"},{"type":"print","value":"2090-6560"}],"subject":[],"published":{"date-parts":[[2021,10,14]]}}}