{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T12:30:33Z","timestamp":1751977833325,"version":"3.40.5"},"reference-count":18,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,12,30]],"date-time":"2021-12-30T00:00:00Z","timestamp":1640822400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Medicine"],"published-print":{"date-parts":[[2021,12,30]]},"abstract":"<jats:p>Objective. The aim of the present study was to report the physiological stimulation of the synthesis of preelastic fibers in the dermis of a patient with fibrosis. Design. A clinical study was conducted involving the analysis of histological changes in preelastic fibers following treatment for stage II primary lymphedema for the clinical reversal of lymphedema and fibrosis. Setting. University Hospital of the S\u00e3o Jose do Rio Preto of School of Medicine in 2020. Participant was a 67-year-old male patient with late-onset primary lymphedema diagnosed 12 years earlier. Intervention is the lymphatic stimulation using the Godoy method adapted to the treatment of fibrosis. Main outcomes and measures are biopsies before and after treatment. Ten randomly selected histological fields were evaluated using the multipoint morphometric method. The values with this method are relative and expressed as percentages. Statistical analysis was performed with the t-test, considering a 95% significance level. Results. A visible, significant difference in the percentage of preelastic fibers was found between the preintervention and postintervention slides, which were confirmed by the microscopic evaluation and quantification (4.95\u2009\u00b1\u20090.64% and 14.70\u2009\u00b1\u20091.06%, respectively). Conclusion. The physiological stimulation of the lymphatic system using a specific method resulted in the clinical reduction of fibrosis, the return of the elasticity of the skin, and the stimulation of the synthesis of preelastic fibers.<\/jats:p>","DOI":"10.1155\/2021\/2666867","type":"journal-article","created":{"date-parts":[[2021,12,31]],"date-time":"2021-12-31T04:20:22Z","timestamp":1640924422000},"page":"1-4","source":"Crossref","is-referenced-by-count":6,"title":["Physiological Stimulation of the Synthesis of Preelastic Fibers in the Dermis of a Patient with Fibrosis"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5424-7787","authenticated-orcid":true,"given":"Jose Maria","family":"Pereira de Godoy","sequence":"first","affiliation":[{"name":"Adjunct Cardiology and Cardiovascular Surgery Department of the Medicine School, S\u00e3o Jos\u00e9 Do Rio Preto (FAMERP), CNPq (National Council for Research and Development), S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1036-8779","authenticated-orcid":true,"given":"L\u00edvia Maria","family":"Pereira de Godoy","sequence":"additional","affiliation":[{"name":"Dermatology, Instituto Lauro de Souza Lima-Bauru-Brazil, Member of Researcher Group, Cl\u00ednica Godoy, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3725-7961","authenticated-orcid":true,"given":"Maria","family":"de Fatima Guerreiro Godoy","sequence":"additional","affiliation":[{"name":"Medicine School, S\u00e3o Jos\u00e9 Do Rio Preto (FAMERP) and Research Group, The Cl\u00ednica Godoy, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1218-6717","authenticated-orcid":true,"given":"Dalisio de Santi","family":"Neto","sequence":"additional","affiliation":[{"name":"Hospital de Base- Medicine School, S\u00e3o Jos\u00e9 Do Rio Preto (FAMERP), S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms9574"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms9574"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2807"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.004077"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2020-0182TR"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2020.08.023"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1111\/joa.13217"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.6.9909098"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1002\/hep.25567"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.160.5.9812040"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.10756"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcn015"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/4305910"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.23736\/S1593-232X.20.00463-4"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.23736\/S1593-232X.21.00489-6"},{"key":"16","first-page":"131","article-title":"Principles and methods for the morphometric study of the lung and other organs","volume":"12","author":"E. R. Weibel","year":"1963","journal-title":"Laboratory investigation; a journal of technical methods and pathology"},{"key":"17","article-title":"Stimulation of synthesis and lysis of extracellular matrix proteins in lymphedema treatment","volume":"19","author":"J. M. P. Godoy","year":"2021","journal-title":"Lymphology (Booklet 28th World Congress of Lymphology-ISL)"},{"key":"18","article-title":"The new lymphology: clinical and histological reversal of fibrosis in all clinical stages of lymphedema","volume":"71","author":"J. M. Pereira de Godoy","year":"2021","journal-title":"Lymphology (Booklet 28th World Congress of Lymphology-ISL)"}],"container-title":["Case Reports in Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crim\/2021\/2666867.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crim\/2021\/2666867.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crim\/2021\/2666867.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,31]],"date-time":"2021-12-31T04:20:26Z","timestamp":1640924426000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/crim\/2021\/2666867\/"}},"subtitle":[],"editor":[{"given":"Mamede","family":"de Carvalho","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2021,12,30]]},"references-count":18,"alternative-id":["2666867","2666867"],"URL":"https:\/\/doi.org\/10.1155\/2021\/2666867","relation":{},"ISSN":["1687-9635","1687-9627"],"issn-type":[{"type":"electronic","value":"1687-9635"},{"type":"print","value":"1687-9627"}],"subject":[],"published":{"date-parts":[[2021,12,30]]}}}