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Changing gut microbiota is one of the most common causes of host gut inflammation. The active triple peptides, lle\u2010Gln\u2010Trp (IQW) and lle\u2010Arg\u2010Trp (IRW), cause remarkable changes to gut microbiota. The effects of the triple peptides IQW and IRW in gut\u2010damage treatment were explored in this study via an enterotoxigenic <jats:italic>Escherichia coli<\/jats:italic>\u2010 (ETEC\u2010) induced mouse model. <jats:italic>Methods.<\/jats:italic> The mice were randomly distributed into four groups: (a) control (CTRL) group, (b) ETEC group, (c) IQW\u2010ETEC group, and (d) IRW\u2010ETEC group. Villus length and crypt depth were measured after hematoxylin and eosin staining. The inflammatory reaction was analyzed via inflammatory cytokines (i.e., TNF\u2010<jats:italic>\u03b1<\/jats:italic>, IL\u20101<jats:italic>\u03b2<\/jats:italic>, IL\u20106, and IL\u201010) using the enzyme\u2010linked immunosorbent assay (ELISA). The microbiota in the colon was sequenced using 16S ribosomal RNA. <jats:italic>Results.<\/jats:italic> The villus length decreased, the crypt depth decreased, and the expression of inflammatory cytokines (i.e., TNF\u2010<jats:italic>\u03b1<\/jats:italic>, IL\u20101<jats:italic>\u03b2<\/jats:italic>, IL\u20106, and IL\u201010) increased due to ETEC. In the IRW\u2010ETEC and IQW\u2010ETEC groups, the Shannon index decreased (<jats:italic>P<\/jats:italic> &lt; 0.05). IQW and IRW increased the abundance of <jats:italic>Firmicutes<\/jats:italic>, <jats:italic>Proteobacteria<\/jats:italic>, <jats:italic>Clostridiales<\/jats:italic>, <jats:italic>Lachnospiraceae<\/jats:italic>, and <jats:italic>Alloprevotella<\/jats:italic>; contrastingly, it decreased the abundance of <jats:italic>Epsilonproteobacteria<\/jats:italic>, <jats:italic>Erysipelotrichales<\/jats:italic>, <jats:italic>Prevotellaceae<\/jats:italic>, and <jats:italic>Flavobacteriaceae<\/jats:italic> compared to the ETEC group (<jats:italic>P<\/jats:italic>\u2009&lt;0.05). <jats:italic>Conclusion.<\/jats:italic> This study ascertained that the addition of IQW and IRW could alleviate jejunal inflammation and increase microbiota community diversity.<\/jats:p>","DOI":"10.1155\/2021\/2752265","type":"journal-article","created":{"date-parts":[[2021,9,24]],"date-time":"2021-09-24T18:12:58Z","timestamp":1632507178000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Effects of IQW and IRW on Inflammation and Gut Microbiota in ETEC\u2010Induced Diarrhea"],"prefix":"10.1155","volume":"2021","author":[{"given":"Naiyuan","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingsi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9532-8444","authenticated-orcid":false,"given":"Jun","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongmei","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9475-5134","authenticated-orcid":false,"given":"Gang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,24]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60844-2"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/jtm\/tax003"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2016.02.001"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2014.09.005"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.aninu.2020.04.004"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1039\/D0FO02176H"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.3382\/ps\/pex185"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/md17120694"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.6b03513"},{"key":"e_1_2_9_10_2","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.201900063","article-title":"Egg white-derived antihypertensive peptide IRW (Ile-Arg-Trp) reduces blood pressure in spontaneously hypertensive rats via the ACE2\/Ang (1-7)\/mas receptor axis","volume":"63","author":"Liao W.","year":"2019","journal-title":"Molecular Nutrition & Food Research"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201500050"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.7b02176"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1039\/C7FO00839B"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201700602"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1021\/jf3046076"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.0c07831"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/6429845"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1159\/000495240"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.f.303"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btr507"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-15-41"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.embor.7400731"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature11551"},{"key":"e_1_2_9_24_2","first-page":"1","article-title":"Parameters and techniques to determine intestinal health of poultry as constituted by immunity, integrity, and functionality","volume":"3","author":"Jeurissen S. 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