{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T21:19:59Z","timestamp":1768252799524,"version":"3.49.0"},"reference-count":53,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,9,14]],"date-time":"2021-09-14T00:00:00Z","timestamp":1631577600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81603707"],"award-info":[{"award-number":["81603707"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["030041102"],"award-info":[{"award-number":["030041102"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013792","name":"Chengdu University","doi-asserted-by":"publisher","award":["81603707"],"award-info":[{"award-number":["81603707"]}],"id":[{"id":"10.13039\/501100013792","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013792","name":"Chengdu University","doi-asserted-by":"publisher","award":["030041102"],"award-info":[{"award-number":["030041102"]}],"id":[{"id":"10.13039\/501100013792","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2021,9,14]]},"abstract":"<jats:p>Functional Dyspepsia (FD) is a common functional gastrointestinal disease, which can reduce the quality of life in patients. Prior research has indicated that insula is closely related to FD and that acupuncture can regulate the functional connectivity (FC) of FD. Therefore, we hypothesized that acupuncture on FD was effected through the insular pathway. To test our hypothesis, we performed electroacupuncture (EA) on FD rat models and then examined the FC between insula and other brain regions through resting-state functional magnetic resonance imaging (rs-fMRI). Seven-day-old male infant Sprague-Dawley (SD) rats were randomly divided into control group, FD model group, and FD acupuncture group, with twelve rats per group (n\u2009=\u200936). Upon establishing successful models, the FD acupuncture group was subjected to EA intervention using Stomach back-shu (BL-21) and front-mu (RN-12) points for ten consecutive days for durations of 20 minutes each day. After intervention, each group was subject to rs-fMRI. The digital image data obtained were analyzed using FC analysis methods. Subsequently, gastric ligation was performed to measure gastric emptying rates. Before EA intervention, the FD model group exhibited decreased functional connections between the insula and a number of brain regions. After EA intervention, FD acupuncture group exhibited increasing FC between insula and regions when compared to the FD model group, such as the primary somatosensory cortex (S1), hippocampal CA3 (CA3), polymorphic layer of dentate gyrus (PoDG), caudate putamen (CPu), and oral pontine reticular nuclei (PnO) <jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mfenced open=\"(\" close=\")\" separators=\"|\">\n                           <a:mrow>\n                              <a:mi>P<\/a:mi>\n                              <a:mo>&lt;<\/a:mo>\n                              <a:mn>0.05<\/a:mn>\n                           <\/a:mrow>\n                        <\/a:mfenced>\n                     <\/a:math>\n                  <\/jats:inline-formula>; decreasing FC was also exhibited between insula and regions such as the bilateral primary and secondary motor cortexes (M1\/2), paraventricular hypothalamic nucleus (PVA), and limbic cortex (LC). These findings indicate that the effective treatment of FD using EA may be through regulating the abnormal FC between insula and several brain regions, in particular CA3, PoDG, and PVA.<\/jats:p>","DOI":"10.1155\/2021\/2771094","type":"journal-article","created":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T22:35:18Z","timestamp":1631745318000},"page":"1-14","source":"Crossref","is-referenced-by-count":7,"title":["The Influence of Stomach Back-Shu and Front-Mu Points on Insular Functional Connectivity in Functional Dyspepsia Rat Models"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9426-4442","authenticated-orcid":true,"given":"Yuan","family":"Chen","sequence":"first","affiliation":[{"name":"Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6634-4867","authenticated-orcid":true,"given":"Ying","family":"Zhao","sequence":"additional","affiliation":[{"name":"Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7186-2802","authenticated-orcid":true,"given":"Robert Yu-Sheng","family":"Tan","sequence":"additional","affiliation":[{"name":"Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9820-5690","authenticated-orcid":true,"given":"Pu-yue","family":"Zhang","sequence":"additional","affiliation":[{"name":"Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Long","sequence":"additional","affiliation":[{"name":"Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0183-4651","authenticated-orcid":true,"given":"Yu","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Oncology, Chongqing Beibei Traditional Chinese Medical Hospital, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8581-7575","authenticated-orcid":true,"given":"Hua-bin","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Acupuncture and Moxibustion, Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v26.i19.2440"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v12.i17.2661"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.05.030"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2012.05128.x"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2004.02274.x"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1586\/17512433.2013.811206"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/3862916"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.53"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13345"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2009.03.080"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/1531958"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.05.003"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/860463"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0068205"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2013.03.019"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1097\/wnp.0000000000000377"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2014.09.019"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1002\/cne.10120"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/291764"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i48.13480"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/3524641"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00400.2006"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/3575231"},{"issue":"1","key":"24","first-page":"53","article-title":"Sini San ameliorates duodenal mucosal barrier injury and low-grade inflammation via the CRF pathway in a rat model of functional dyspepsia","volume":"45","author":"C. 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