{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T08:01:25Z","timestamp":1767168085646,"version":"build-2238731810"},"reference-count":25,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T00:00:00Z","timestamp":1638835200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Healthcare Engineering"],"published-print":{"date-parts":[[2021,12,7]]},"abstract":"<jats:p>Osteoarthritis (OA), a chronic disease characterized by articular cartilage degeneration, is a leading cause of disability and pain worldwide. Accumulating evidence indicates that circular RNAs (circRNAs) play a critical role in various diseases, but the function of circRNAs in OA remains largely unknown. In this study, we found that circ_0001598 was significantly upregulated in chondrocytes treated with IL-1\u03b2 and in cartilage tissue from mice with severed anterior cruciate ligament surgery (ACLT) induced OA models. Interference with circ_0001598 in vitro restored IL-1\u03b2-induced chondrocyte proliferation and apoptosis. Silencing circ_0001598 significantly alleviated ACLT-induced OA in mice. Mechanistically, knockdown of circ_0001598 affected chondrocyte proliferation, apoptosis, and matrix degradation by regulating miR-127-3p. Taken together, our results demonstrate the fundamental role of circ_0001598 and provide new ideas for the prevention and treatment of osteoarthritis.<\/jats:p>","DOI":"10.1155\/2021\/2793379","type":"journal-article","created":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T18:50:07Z","timestamp":1638903007000},"page":"1-8","source":"Crossref","is-referenced-by-count":4,"title":["Circular RNA mmu_circ_0001598 Contributes to IL-1\u03b2-Induced Osteoarthritis Progression by Regulating miR-127-3p"],"prefix":"10.1155","volume":"2021","author":[{"given":"Xierenguli","family":"Apizi","sequence":"first","affiliation":[{"name":"Department of Pain Treatment, People\u2019s Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Uygur Autonomous Region, Urumqi 830001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dilibaier","family":"Talifujiang","sequence":"additional","affiliation":[{"name":"Department of Pain Treatment, People\u2019s Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Uygur Autonomous Region, Urumqi 830001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aziguli","family":"Kasimu","sequence":"additional","affiliation":[{"name":"Department of Pain Treatment, People\u2019s Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Uygur Autonomous Region, Urumqi 830001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pain Treatment, People\u2019s Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Uygur Autonomous Region, Urumqi 830001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aibibula","family":"Yiming","sequence":"additional","affiliation":[{"name":"Department of Pain Treatment, People\u2019s Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Uygur Autonomous Region, Urumqi 830001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Pain Treatment, People\u2019s Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Uygur Autonomous Region, Urumqi 830001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingshan","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Pain Treatment, People\u2019s Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Uygur Autonomous Region, Urumqi 830001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3931-5133","authenticated-orcid":true,"given":"Dequan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pain Treatment, People\u2019s Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Uygur Autonomous Region, Urumqi 830001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1002\/art.38778"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(14)60802-3"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2016.07.017"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(11)60243-2"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2006.06.003"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2015.04.005"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2006.06.012"},{"issue":"2","key":"8","first-page":"455","article-title":"Apoptotic chondrocyte death in human osteoarthritis","volume":"27","author":"H. 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