{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T08:14:28Z","timestamp":1767168868226,"version":"build-2238731810"},"reference-count":25,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,11,12]],"date-time":"2021-11-12T00:00:00Z","timestamp":1636675200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81471617"],"award-info":[{"award-number":["81471617"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Computational and Mathematical Methods in Medicine"],"published-print":{"date-parts":[[2021,11,12]]},"abstract":"<jats:p>\n                    To study the clinical features of infectious mononucleosis (IM) caused by Epstein-Barr virus (EBV) mixed with Mycoplasma pneumonia (MP) or\/and cytomegalovirus (CMV)infection, collected 201 hospitalized children who met the IM diagnostic criteria, the clinical manifestations, laboratory tests, complications, treatment, and outcome were compared among EBV infection alone and EBV mixed with MP or\/and CMV infection. Most of the children with IM were preschoolers, more frequently occurred in boys than girls. EBV patients with MP had the longest duration of fever. When mixed pathogen infections were involved, the white blood cell count of preschool children was significantly increased, while splenomegaly was more common in older children. In the cases of EBV infection alone, abnormal liver function was positively correlated with age (\n                    <jats:inline-formula>\n                      <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>=<\/a:mo>\n                        <a:mn>0.044<\/a:mn>\n                      <\/a:math>\n                    <\/jats:inline-formula>\n                    ). Mixed pathogen infections were more common in children with IM, occurring in all age groups, and some clinical characteristics were related to the age of onset and the pathogen of the infection.\n                  <\/jats:p>","DOI":"10.1155\/2021\/2867913","type":"journal-article","created":{"date-parts":[[2021,11,12]],"date-time":"2021-11-12T13:20:09Z","timestamp":1636723209000},"page":"1-5","source":"Crossref","is-referenced-by-count":2,"title":["Clinical Characteristics and Empirical Research Model of Infectious Mononucleosis Complicated with Mycoplasma pneumoniae or\/and Cytomegalovirus Infection"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1667-8740","authenticated-orcid":true,"given":"Jie","family":"Cai","sequence":"first","affiliation":[{"name":"Department of Pediatrics, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liping","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Gui","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"issue":"3","key":"1","first-page":"463","article-title":"Clinical characteristics and levels of serum immune factors in children with EBV infection","volume":"31","author":"R. 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Yanfeng","year":"2020","journal-title":"Chinese Journal of Nosocomiology"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-7-247"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiac.2019.01.012"},{"issue":"12","key":"19","first-page":"1147","article-title":"Clinical analysis of 82 cases of infectious mononucleosis in children","volume":"46","author":"G. Q. Dong","year":"2017","journal-title":"Journal of China Medical University"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2013.19.4.382"},{"issue":"10","key":"21","first-page":"1","article-title":"Clinical manifestations and laboratory results of 61 children with infectious mononucleosis","volume":"13","author":"Y. M. Wu","year":"2020","journal-title":"The Journal of International Medical Research"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1515\/ijamh-2018-0284"},{"issue":"1","key":"23","first-page":"23","article-title":"Clinical analysis of 110 cases of infectious mononucleosis in children","volume":"19","author":"H. Wang","year":"2019","journal-title":"Chinese Journal of Infection and Chemotherapy"},{"key":"24","article-title":"EB virus antibody titer, EB virus DNA load and clinical characteristics of infectious mononucleosis patients: a retrospective analysis","volume":"36","author":"N. Li","year":"2018","journal-title":"Chinese Journal of Infectious Diseases"},{"key":"25","first-page":"898","article-title":"Clinical observation and immune regulation of Chaihu mixture in treating 40 cases of infectious mononucleosis in children","volume":"12","author":"J. Liu","year":"2018","journal-title":"Tianjin Traditional Chinese Medicine"}],"updated-by":[{"DOI":"10.1155\/2023\/9827621","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T00:00:00Z","timestamp":1687910400000},"record-id":"47311"},{"DOI":"10.1155\/2023\/9827621","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T00:00:00Z","timestamp":1687910400000}}],"container-title":["Computational and Mathematical Methods in Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2021\/2867913.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2021\/2867913.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2021\/2867913.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,12]],"date-time":"2021-11-12T13:20:26Z","timestamp":1636723226000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/cmmm\/2021\/2867913\/"}},"subtitle":[],"editor":[{"given":"Min","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2021,11,12]]},"references-count":25,"alternative-id":["2867913","2867913"],"URL":"https:\/\/doi.org\/10.1155\/2021\/2867913","relation":{},"ISSN":["1748-6718","1748-670X"],"issn-type":[{"value":"1748-6718","type":"electronic"},{"value":"1748-670X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11,12]]}}}