{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T14:49:07Z","timestamp":1776610147952,"version":"3.51.2"},"reference-count":59,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,11,24]],"date-time":"2021-11-24T00:00:00Z","timestamp":1637712000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2021,11,24]]},"abstract":"<jats:p>Cyclophosphamide is a commonly used anticancer drug, and immunosuppression is one of the most common side effects. How to recover the immunological function is important for cyclophosphamide-treated patients. In the present study, Phellodendri Cortex polysaccharides (CPP) could enhance the proliferation of mouse spleen lymphocytes in vitro. The immunoregulatory function of CPP was then investigated in cyclophosphamide-induced immunosuppressed mice. In CPP-treated groups, mice were orally treated with CPP at doses of 1, 0.5, and 0.25\u2009g\/kg bodyweight from 1 to 11\u2009d, respectively. The cyclophosphamide was administrated in CPP and cyclophosphamide groups from 12 to 14\u2009d. In the cyclophosphamide and normal control groups, the mice received equal volume of saline from 1 to 14\u2009d. The results showed that CPP (1\u2009g\/kg) could significantly increase the bodyweight of mice, even during cyclophosphamide treatment. The organ coefficients of the spleen and thymus were recovered by CPP treatment. CPP upregulated the contents of cytokines (IL-2, IL-6, IFN-\u03b3, and TNF-\u03b1) in serum, which were downregulated by cyclophosphamide. The mRNA levels of these cytokines were also elevated by CPP treatment in the spleen. Cyclophosphamide upregulated the expressions of NF-\u03baB p65, TLR4, and MyD88, suggesting that the NF-\u03baB signaling pathway was activated by cyclophosphamide. After CPP treatment, it was recovered to normal level. These results indicated that CPP alleviated the cyclophosphamide-induced immunosuppression.<\/jats:p>","DOI":"10.1155\/2021\/3027708","type":"journal-article","created":{"date-parts":[[2021,11,24]],"date-time":"2021-11-24T16:05:49Z","timestamp":1637769949000},"page":"1-9","source":"Crossref","is-referenced-by-count":7,"title":["The Immunomodulatory Effects of Phellodendri Cortex Polysaccharides on Cyclophosphamide-Induced Immunosuppression in Mice"],"prefix":"10.1155","volume":"2021","author":[{"given":"Yi","family":"Cheng","sequence":"first","affiliation":[{"name":"Department of Physical Education, Chengdu University of Information Technology, Chengdu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Physical Education, Chengdu University of Information Technology, Chengdu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simei","family":"Mo","sequence":"additional","affiliation":[{"name":"Department of Physical Education, Chengdu University of Information Technology, Chengdu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianxiong","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Physical Education, Chengdu University of Information Technology, Chengdu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongjian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Physical Education, Chengdu University of Information Technology, Chengdu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heli","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Physical Education, Chengdu University of Information Technology, Chengdu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunsheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Physical Education, Chengdu University of Information Technology, Chengdu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Song","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lixia","family":"Li","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2571-5005","authenticated-orcid":true,"given":"Zhe","family":"Geng","sequence":"additional","affiliation":[{"name":"Department of Physical Education, Chengdu University of Information Technology, Chengdu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/7621929"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/8703239"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.201400475"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/s0378-8741(00)00302-0"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.3109\/08923970903193325"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2011.08.014"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2014.04.042"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1248\/yakushi1947.109.9_672"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellbi.2009.06.006"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1002\/vms3.304"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1023\/a:1007084506071"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2007.10.011"},{"key":"13","doi-asserted-by":"crossref","DOI":"10.1177\/2156587218757649","article-title":"Protective effect of kolaviron on cyclophosphamide-induced cardiac toxicity in rats","volume":"23","author":"J. G. Omole","year":"2018","journal-title":"Journal of Evidence-Based Integrative Medicine"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2018.02.005"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2018.12.018"},{"key":"16","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/978-981-13-3681-2_2","article-title":"The immune system and its dysregulation with aging","volume":"91","author":"L. M\u00fcller","year":"2019","journal-title":"Sub-cellular biochemistry"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2297"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1017\/s0029665112000092"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2011.07.002"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsi.2020.06.005"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2008.04.020"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4933-9-15"},{"key":"23","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.bbi.2013.11.015","article-title":"Aging and immunity \u2013 impact of behavioral intervention","volume":"39","author":"M. Ludmila","year":"2014","journal-title":"Journal of Brain Behavior & Immunity"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1007\/bf02857190"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2016.0148"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2018.01.086"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.2174\/1389450118666170123145357"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2018.10.083"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2018.01.010"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.29452"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110469"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2018.04.056"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2020.02.203"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00145"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1007\/s11259-014-9621-2"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1186\/1746-6148-9-257"},{"issue":"1","key":"37","first-page":"75","article-title":"Histological and functional differentiation of non-lymphoid cells in the chicken spleen[J]","volume":"77","author":"S. H. M. Jeurissen","year":"1992","journal-title":"Immunology"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0144375"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2020.06.120"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2020.09.213"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.12659\/msm.902137"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23020239"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/4353580"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1016\/s0020-7519(01)00275-2"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1016\/s0167-5699(99)01573-x"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.02.040184.001435"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3153"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1097\/bor.0000000000000255"},{"issue":"6","key":"49","doi-asserted-by":"crossref","first-page":"2482","DOI":"10.4049\/jimmunol.1401190","article-title":"Cutting edge: circulating plasmablasts induce the differentiation of human T follicular helper cells via IL-6 production","volume":"194","author":"K. M. Chavele","year":"2015","journal-title":"The Journal of Immunology (Baltimore)"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20111675"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a016295"},{"issue":"9","key":"52","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.imbio.2005.07.003","article-title":"Sources of interferon-gamma (IFN-gamma) in early immune response to Listeria monocytogenes","volume":"210","author":"C. Th\u00e4le","year":"2005","journal-title":"Immunobiology"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.86.10.1166"},{"key":"54","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.07.040189.003205"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2017.52"},{"key":"56","doi-asserted-by":"publisher","DOI":"10.1038\/nri910"},{"key":"57","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2003.10.003"},{"key":"58","doi-asserted-by":"publisher","DOI":"10.1111\/sji.12771"},{"key":"59","doi-asserted-by":"publisher","DOI":"10.1016\/s1074-7613(02)00390-4"}],"container-title":["Evidence-Based Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2021\/3027708.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2021\/3027708.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2021\/3027708.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T19:24:57Z","timestamp":1726169097000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/ecam\/2021\/3027708\/"}},"subtitle":[],"editor":[{"given":"Michel Mansur","family":"Machado","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2021,11,24]]},"references-count":59,"alternative-id":["3027708","3027708"],"URL":"https:\/\/doi.org\/10.1155\/2021\/3027708","relation":{},"ISSN":["1741-4288","1741-427X"],"issn-type":[{"value":"1741-4288","type":"electronic"},{"value":"1741-427X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11,24]]}}}