{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:32:28Z","timestamp":1792787548691,"version":"4.5.0"},"reference-count":44,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T00:00:00Z","timestamp":1637193600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Beijing Hospitals Authority Clinical Medicine Development of Special Funding","award":["ZYLX202106"],"award-info":[{"award-number":["ZYLX202106"]}]},{"name":"Beijing Hospitals Authority Clinical Medicine Development of Special Funding","award":["2018\u201312"],"award-info":[{"award-number":["2018\u201312"]}]},{"name":"Beijing Hospitals Authority Clinical Medicine Development of Special Funding","award":["2018-4-2034"],"award-info":[{"award-number":["2018-4-2034"]}]},{"DOI":"10.13039\/501100017616","name":"Beijing Talents foundation","doi-asserted-by":"crossref","award":["ZYLX202106"],"award-info":[{"award-number":["ZYLX202106"]}],"id":[{"id":"10.13039\/501100017616","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100017616","name":"Beijing Talents foundation","doi-asserted-by":"crossref","award":["2018\u201312"],"award-info":[{"award-number":["2018\u201312"]}],"id":[{"id":"10.13039\/501100017616","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100017616","name":"Beijing Talents foundation","doi-asserted-by":"crossref","award":["2018-4-2034"],"award-info":[{"award-number":["2018-4-2034"]}],"id":[{"id":"10.13039\/501100017616","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Capital Funds for Health Improvement and Research","award":["ZYLX202106"],"award-info":[{"award-number":["ZYLX202106"]}]},{"name":"Capital Funds for Health Improvement and Research","award":["2018\u201312"],"award-info":[{"award-number":["2018\u201312"]}]},{"name":"Capital Funds for Health Improvement and Research","award":["2018-4-2034"],"award-info":[{"award-number":["2018-4-2034"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Endocrinology"],"published-print":{"date-parts":[[2021,11,18]]},"abstract":"<jats:p>\n                    Objective. Irisin, a novel myokine, has recently been considered to produce a cardioprotective effect. Potential biomarkers for myocardial injuries in patients with severe hypothyroidism have yet to be identified. We aimed to investigate whether serum irisin may serve as a promising biomarker for early detecting the myocardial injuries in patients with severe hypothyroidism. Methods. This cross-sectional study comprised 25 newly diagnosed drug-naive patients with severe primary hypothyroidism and 17 age- and sex-matched healthy controls. Circulating irisin levels and cardiac magnetic resonance (CMR) were evaluated in each participant. Left ventricular (LV) myocardial injuries were detected by CMR-based T1 mapping technique using a modified look-locker inversion recovery (MOLLI) sequence, which is quantified as native T1 values. Results. Compared with healthy controls, the severe hypothyroidism group had significantly lower levels of serum irisin, especially those with pericardial effusion (\n                    <jats:inline-formula>\n                      <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>&lt;<\/a:mo>\n                        <a:mn>0.05<\/a:mn>\n                      <\/a:math>\n                    <\/jats:inline-formula>\n                    ). The severe hypothyroidism subjects exhibited lower peak filling rates (PFRs) and higher native myocardial T1 values than controls (\n                    <jats:inline-formula>\n                      <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>P<\/c:mi>\n                        <c:mo>&lt;<\/c:mo>\n                        <c:mn>0.05<\/c:mn>\n                      <\/c:math>\n                    <\/jats:inline-formula>\n                    ). Additionally, the ROC analysis displayed that the sensitivity and specificity of serum irisin for diagnosing pericardial effusion in patients with severe hypothyroidism were 73.3% and 100.0%, respectively. The AUC was 0.920 (0.861\u20131.000) (\n                    <jats:inline-formula>\n                      <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>P<\/e:mi>\n                        <e:mo>&lt;<\/e:mo>\n                        <e:mn>0.001<\/e:mn>\n                      <\/e:math>\n                    <\/jats:inline-formula>\n                    ). The cutoff value was 36.94\u2009ng\/mL. Moreover, the results in subgroup analysis revealed that the native T1 values of the low-irisin group were significantly higher than that of the high-irisin group (\n                    <jats:inline-formula>\n                      <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>P<\/g:mi>\n                        <g:mo>&lt;<\/g:mo>\n                        <g:mn>0.05<\/g:mn>\n                      <\/g:math>\n                    <\/jats:inline-formula>\n                    ). According to multivariate linear regression analysis, serum irisin concentrations were negatively and independently correlated with native myocardial T1 values after adjustment for age, sex, and other conventional confounding factors (\u03b2\u2009=\u2009\u22121.473,\n                    <jats:inline-formula>\n                      <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <i:mi>P<\/i:mi>\n                        <i:mo>&lt;<\/i:mo>\n                        <i:mn>0.05<\/i:mn>\n                      <\/i:math>\n                    <\/jats:inline-formula>\n                    ). Conclusions. Irisin may be a potential biomarker for predicting myocardial injuries in patients with severe hypothyroidism.\n                  <\/jats:p>","DOI":"10.1155\/2021\/3116068","type":"journal-article","created":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T15:05:15Z","timestamp":1637247915000},"page":"1-8","source":"Crossref","is-referenced-by-count":6,"title":["Irisin as a Potential Biomarker Associated with Myocardial Injuries in Patients with Severe Hypothyroidism"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6766-5216","authenticated-orcid":true,"given":"Zhi","family":"Yao","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8490-512X","authenticated-orcid":true,"given":"Xiaoyu","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9948-3732","authenticated-orcid":true,"given":"Xia","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6467-4560","authenticated-orcid":true,"given":"Ning","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8718-5105","authenticated-orcid":true,"given":"Yumei","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6957-3814","authenticated-orcid":true,"given":"Jia","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9321-5200","authenticated-orcid":true,"given":"Guang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10777"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-2749"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2016.07.022"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2016.221"},{"key":"5","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1111\/apha.12686","article-title":"Crosstalk between adipokines and myokines in fat browning","volume":"219","author":"A. 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