{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T16:10:56Z","timestamp":1784823056693,"version":"3.55.0"},"reference-count":55,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,10,27]],"date-time":"2021-10-27T00:00:00Z","timestamp":1635292800000},"content-version":"vor","delay-in-days":299,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["2016\/21\/B\/NZ5\/01901"],"award-info":[{"award-number":["2016\/21\/B\/NZ5\/01901"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>IL\u201017A and IL\u201017F together with their coreceptor (IL\u201017RA\/RC) were reported to play a significant role in the pathogenesis of spondyloarthritis. The group of axial spondyloarthritis comprises ankylosing spondylitis (AS), a rheumatic disease characterized by chronic inflammation of the joints in the spine. This study is aimed at investigating <jats:italic>IL-17A<\/jats:italic>, <jats:italic>IL-17F<\/jats:italic>, <jats:italic>IL-17RA<\/jats:italic>, and <jats:italic>IL-17RC<\/jats:italic> polymorphisms as potential biomarkers of disease susceptibility, clinical parameters, and anti\u2010TNF treatment outcome in a cohort of Polish ankylosing spondylitis patients. In total, 328 subjects, including 138 AS patients and 190 healthy volunteers, participated in the study. Genotyping of <jats:italic>IL-17A<\/jats:italic> rs2275913 (G\/A), <jats:italic>IL-17F<\/jats:italic> rs763780 (A\/G), <jats:italic>IL-17RA<\/jats:italic> rs4819554 (A\/G), and <jats:italic>IL-17RC<\/jats:italic> rs708567 (G\/A) was performed on real\u2010time PCR instrument using LightSNiP assays. No significant differences were revealed in genotype and allele distribution between patients and controls despite the association of the <jats:italic>IL-17RC<\/jats:italic> rs708567 <jats:italic>AA<\/jats:italic> homozygosity with the earlier onset of the disease. Moreover, some relationships between <jats:italic>IL-17F<\/jats:italic> rs763780 and <jats:italic>IL-17RA<\/jats:italic> rs4819554 polymorphisms with clinical parameters related to the disease activity and anti\u2010TNF treatment outcome were observed. <jats:italic>IL-17F<\/jats:italic> rs763780 G allele was found to be associated with high disease activity and BASDAI after 6 months and poor response to the treatment while higher VAS values were more common among <jats:italic>IL-17RA<\/jats:italic> rs4819554 G variant carriers. In conclusion, the <jats:italic>IL-17F<\/jats:italic> rs763780 polymorphism should be considered as a promising biomarker of disease activity and anti\u2010TNF treatment outcome. The <jats:italic>IL-17RA<\/jats:italic> rs48419554 G allele may serve as a potential marker of disease severity in Polish AS patients.<\/jats:p>","DOI":"10.1155\/2021\/3125922","type":"journal-article","created":{"date-parts":[[2021,10,27]],"date-time":"2021-10-27T15:36:02Z","timestamp":1635348962000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Polymorphisms within Genes Coding for IL\u201017A and F and Their Receptor as Clinical Hallmarks in Ankylosing 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