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In this context, <jats:italic>Spirulina platensis<\/jats:italic> (SP), some blue\u2010green algae with antioxidant action, appears as a potential therapeutic alternative to prevent obesity and associated intestinal disorders. Thus, the present study is aimed at evaluating the deleterious effects of the hypercaloric diet on the contractile and relaxing reactivity of the ileum of rats, as well as the possible preventive mechanisms of dietary supplementation with SP. Wistar rats were divided into three groups: fed a standard diet (SD), a hypercaloric diet (HCD), and\/or supplemented with 25\u2009mg\/kg SP (HCD + SP25) for 8 weeks. The hypercaloric diet was effective in promoting obesity in rats, as well as decreasing potency and ileal relaxing and contractile efficacy. In contrast, dietary supplementation with SP was able to prevent some of the parameters of experimental obesity. In addition, SP prevented the reduction of intestinal reactivity, possibly due to a positive modulation of voltage\u2010gated calcium channels (Ca<jats:sub>V<\/jats:sub>) and negative regulation of muscarinic receptors (M3). Thus, food supplementation with <jats:italic>Spirulina platensis<\/jats:italic> becomes a promising alternative in the prevention of gastrointestinal diseases induced and\/or aggravated by obesity.<\/jats:p>","DOI":"10.1155\/2021\/3260789","type":"journal-article","created":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T01:35:09Z","timestamp":1627522509000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["<i>Spirulina platensis<\/i> Consumption Prevents Obesity and Improves the Deleterious Effects on Intestinal Reactivity in Rats Fed a Hypercaloric Diet"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9659-1495","authenticated-orcid":false,"given":"Anderson Fellyp Avelino","family":"Diniz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brena Freire","family":"de Oliveira Claudino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoel Vieira","family":"Duvirgens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petruska Pessoa","family":"da Silva Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula Benvindo","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Fernandes Lacerda","family":"J\u00fanior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriano Francisco","family":"Alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bagn\u00f3lia Ara\u00fajo","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,28]]},"reference":[{"key":"e_1_2_10_1_2","unstructured":"BrennanV. 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