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Studies have shown that probiotic intervention in the aging stage could delay aging\u2010related disorders. However, whether the application of probiotics in early life could have antiaging effects on offspring was unknown. Here, we investigated the effects of <jats:italic>Lactobacillus rhamnosus GG<\/jats:italic> (<jats:italic>LGG<\/jats:italic>) colonization in early life on inflammaging of offspring. Pregnant mice with the same conception time were given <jats:italic>LGG<\/jats:italic> live bacteria (LC group) or <jats:italic>LGG<\/jats:italic> fixed bacteria (NC group) from the 18th day after pregnancy until natural birth. The progeny mice were treated with 10<jats:sup>7<\/jats:sup>\u2009cfu of live or fixed LGG for 0\u20105 days after birth, respectively. <jats:italic>LGG<\/jats:italic> colonization could be detected in the feces of 3\u2010week offspring. The 16S rRNA sequencing analysis of 3\u2010week\u2010old offspring showed that colonization of <jats:italic>LGG<\/jats:italic> in early life could alter the composition and diversity of gut microbiota. Interestingly, the beneficial effects of <jats:italic>LGG<\/jats:italic> colonization in early life on the microbiota lasted to 8 months old. The abundance of longevity\u2010related bacteria (<jats:italic>Lactobacillus<\/jats:italic>, <jats:italic>Bifidobacterium<\/jats:italic>, and <jats:italic>Akkermansia muciniphila<\/jats:italic>) increased significantly in the <jats:italic>LGG<\/jats:italic> colonization group. In addition, <jats:italic>LGG<\/jats:italic> colonization increased the abundance of short\u2010chain fatty acid\u2010 (SCFA\u2010) producing bacteria and the production of cecal SCFAs. <jats:italic>LGG<\/jats:italic> colonization in early life protected the intestinal barrier, enhanced antioxidant defense, attenuated epithelial cell DNA damage, and inhibited intestinal low\u2010grade inflammation in 8\u2010month\u2010old progeny mice. Mechanically, <jats:italic>LGG<\/jats:italic> could upregulate Sirtuin1 (SIRT1)\/Adenosine 5\u2009<jats:sup>\u2032<\/jats:sup>\u2010monophosphate\u2010activated protein kinase (AMPK)\/Peroxisome proliferator\u2010activated receptor <jats:italic>\u03b3<\/jats:italic> coactivator 1\u2010<jats:italic>\u03b1<\/jats:italic> (PGC\u20101<jats:italic>\u03b1<\/jats:italic>) pathway and repress activation of nuclear factor\u2010kappa B (NF\u2010<jats:italic>\u03ba<\/jats:italic>B), while the protective effect of <jats:italic>LGG<\/jats:italic> was blunted after SIRT1 gene silencing. Together, <jats:italic>LGG<\/jats:italic> colonization in early life could ameliorate inflammaging of offspring, which would provide a new strategy for the prevention of age\u2010related diseases.<\/jats:p>","DOI":"10.1155\/2021\/3328505","type":"journal-article","created":{"date-parts":[[2021,11,12]],"date-time":"2021-11-12T02:50:09Z","timestamp":1636685409000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["<i>Lactobacillus rhamnosus GG<\/i> Colonization in Early Life Ameliorates Inflammaging of Offspring by Activating SIRT1\/AMPK\/PGC\u20101<i>\u03b1<\/i> 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