{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:13:40Z","timestamp":1790802820015,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T00:00:00Z","timestamp":1633305600000},"content-version":"vor","delay-in-days":276,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003009","name":"Science and Technology Development Fund","doi-asserted-by":"publisher","award":["2021XB030"],"award-info":[{"award-number":["2021XB030"]}],"id":[{"id":"10.13039\/501100003009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81900338"],"award-info":[{"award-number":["81900338"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570227"],"award-info":[{"award-number":["81570227"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Excessive myocardial oxidative stress could lead to the congestive heart failure. NADPH oxidase is involved in the pathological process of left ventricular (LV) remodeling and dysfunction. <jats:italic>\u03b2<\/jats:italic>3\u2010Adrenergic receptor (AR) could regulate cardiac dysfunction proved by recent researches. The molecular mechanism of <jats:italic>\u03b2<\/jats:italic>3\u2010AR regulating oxidative stress, especially NADPH oxidase, remains to be determined. <jats:italic>Methods<\/jats:italic>. Cardiac hypertrophy was constructed by the transverse aortic constriction (TAC) model. ROS and NADPH oxidase subunits expression were assessed after <jats:italic>\u03b2<\/jats:italic>3\u2010AR agonist (BRL) or inhibitor (SR) administration in cardiac hypertrophy. Moreover, the cardiac function, fibrosis, heart size, oxidative stress, and cardiomyocytes apoptosis were also detected. <jats:italic>Results<\/jats:italic>. <jats:italic>\u03b2<\/jats:italic>3\u2010AR activation significantly alleviated cardiac hypertrophy and remodeling in pressure\u2010overloaded mice. <jats:italic>\u03b2<\/jats:italic>3\u2010AR stimulation also improved heart function and reduced cardiomyocytes apoptosis, oxidative stress, and fibrosis. Meanwhile, <jats:italic>\u03b2<\/jats:italic>3\u2010AR stimulation inhibited superoxide anion production and decreased NADPH oxidase activity. Furthermore, BRL treatment increased the neuronal NOS (nNOS) expression in cardiac hypertrophy. <jats:italic>Conclusion<\/jats:italic>. <jats:italic>\u03b2<\/jats:italic>3\u2010AR stimulation alleviated cardiac dysfunction and reduced cardiomyocytes apoptosis, oxidative stress, and fibrosis by inhibiting NADPH oxidases. In addition, the protective effect of <jats:italic>\u03b2<\/jats:italic>3\u2010AR is largely attributed to nNOS activation in cardiac hypertrophy.<\/jats:p>","DOI":"10.1155\/2021\/3417242","type":"journal-article","created":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T17:46:53Z","timestamp":1633369613000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Beta3\u2010Adrenergic Receptor Activation Alleviates Cardiac Dysfunction in Cardiac Hypertrophy by Regulating Oxidative Stress"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8480-0280","authenticated-orcid":false,"given":"Mingming","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuerong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianghong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoshi","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianqiang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingxiao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zikuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8320-5516","authenticated-orcid":false,"given":"Xiaolin","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,4]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.913"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.1474"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2020.03.004"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI120849"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.07.008"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2018.08.010"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2019.07.006"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745-7254.2007.00495.x"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2020.09.013"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.7150\/thno.40098"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2019.101415"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-018-0086-7"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21010358"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00044.2005"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-019-0260-8"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(03)00471-6"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.09.051"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.16304"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.2174\/1381612821666150803151758"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2018.08.017"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2010.09.019"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-198400282-00002"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(00)01562-5"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.12.046"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.1089\/152308603770380098"},{"key":"e_1_2_9_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12265-010-9184-8"},{"key":"e_1_2_9_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-020-09720-2"},{"key":"e_1_2_9_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-019-0773-7"},{"key":"e_1_2_9_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2018.07.011"},{"key":"e_1_2_9_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2017.12.019"},{"key":"e_1_2_9_31_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.011079"},{"key":"e_1_2_9_32_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.035377"},{"key":"e_1_2_9_33_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-018-0682-1"},{"key":"e_1_2_9_34_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvx204"},{"key":"e_1_2_9_35_2","first-page":"103","article-title":"Divergent effects of an alpha2-adrenergic antagonist on lipolysis and thermogenesis: interactions with a beta3-adrenergic agonist in rats","volume":"8","author":"G\u00f3mez-Ambrosi J.","year":"2001","journal-title":"International Journal of Molecular Medicine"},{"key":"e_1_2_9_36_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.004940"},{"key":"e_1_2_9_37_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.412031"}],"updated-by":[{"DOI":"10.1155\/omcl\/9832368","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:00:00Z","timestamp":1760572800000}}],"container-title":["Oxidative Medicine and Cellular Longevity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2021\/3417242.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2021\/3417242.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2021\/3417242","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T18:43:41Z","timestamp":1723056221000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2021\/3417242"}},"subtitle":[],"editor":[{"given":"Yun-dai","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1155\/2021\/3417242"],"URL":"https:\/\/doi.org\/10.1155\/2021\/3417242","archive":["Portico"],"relation":{},"ISSN":["1942-0900","1942-0994"],"issn-type":[{"value":"1942-0900","type":"print"},{"value":"1942-0994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"2021-04-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"3417242"}}