{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:30:51Z","timestamp":1791232251571,"version":"4.1.0"},"reference-count":114,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,10,31]],"date-time":"2021-10-31T00:00:00Z","timestamp":1635638400000},"content-version":"vor","delay-in-days":303,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>This study is aimed at determining the association of inflammatory markers and proinflammatory cytokines with cardiovascular risk manifestation in women with endometriosis as compared to healthy controls. A total of 181 females of reproductive age with the absence of other inflammatory or autoimmune disorders and a lack of hormonal therapy for at least 6 months voluntarily participated in this investigation. Patients were 81 females, laparoscopically diagnosed with endometriosis, while the control group comprised 80 healthy females without any pelvic pathology. All subjects were 20\u201040 years of age. Exclusion criteria were diabetes, obesity, hypertension, metabolic diseases, cardiovascular, and renal disorders. C\u2010reactive protein, fibrinogen, homocysteine, interleukin\u201017, and interleukin\u201033 were analyzed using commercially available ELISA kits. For statistical interpretation, the unpaired Student \u201c<jats:italic>t<\/jats:italic>\u201d test was used. All inflammatory markers and cytokines demonstrated elevated levels (<jats:italic>P<\/jats:italic> &lt; 0.001) in endometriosis patients as compared to healthy controls. The results of the study revealed that the patients with endometriosis demonstrate a hypercoagulable status due to inflammation, which initiates atherosclerosis and associated complications. Hence, endometriosis can cause a risk of cardiovascular disorders in these patients.<\/jats:p>","DOI":"10.1155\/2021\/3425560","type":"journal-article","created":{"date-parts":[[2021,10,31]],"date-time":"2021-10-31T14:20:09Z","timestamp":1635690009000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Association of Inflammatory Markers\/Cytokines with Cardiovascular Risk Manifestation in Patients with Endometriosis"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1063-1880","authenticated-orcid":false,"given":"Uzma","family":"Rafi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0749-187X","authenticated-orcid":false,"given":"Shaaf","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7545-8823","authenticated-orcid":false,"given":"Syeda Shazia","family":"Bokhari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5097-2065","authenticated-orcid":false,"given":"Muhammad Amir","family":"Iqbal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amna","family":"Zia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0071-6979","authenticated-orcid":false,"given":"Muhammad Amjad","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2396-5433","authenticated-orcid":false,"given":"Nabila","family":"Roohi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,31]]},"reference":[{"key":"e_1_2_12_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2019.05.021"},{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60490-4"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.1080\/1071576021000049908"},{"key":"e_1_2_12_4_2","first-page":"333","article-title":"Peritoneal fluid environment in endometriosis","volume":"55","author":"Bedaiwy M. A.","year":"2003","journal-title":"Minerva Ginecologica"},{"key":"e_1_2_12_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2007.06.019"},{"key":"e_1_2_12_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(02)02959-X"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2019.02.022"},{"key":"e_1_2_12_8_2","doi-asserted-by":"publisher","DOI":"10.1159\/000093121"},{"key":"e_1_2_12_9_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0203741"},{"key":"e_1_2_12_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2018.07.006"},{"key":"e_1_2_12_11_2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/158490"},{"key":"e_1_2_12_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00041433-200110000-00003"},{"key":"e_1_2_12_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(98)00088-0"},{"key":"e_1_2_12_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2002.tb02779.x"},{"key":"e_1_2_12_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/des154"},{"key":"e_1_2_12_16_2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/2916070"},{"key":"e_1_2_12_17_2","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.14817.1"},{"key":"e_1_2_12_18_2","doi-asserted-by":"publisher","DOI":"10.5114\/ceji.2015.50840"},{"key":"e_1_2_12_19_2","doi-asserted-by":"publisher","DOI":"10.5114\/ceji.2015.54603"},{"key":"e_1_2_12_20_2","doi-asserted-by":"publisher","DOI":"10.2174\/1389450116666150202161500"},{"key":"e_1_2_12_21_2","doi-asserted-by":"publisher","DOI":"10.4103\/ejim.ejim_37_17"},{"key":"e_1_2_12_22_2","first-page":"2597","article-title":"Increased prevalence of atherosclerosis in patients with medium term rheumatoid arthritis","volume":"28","author":"Jonsson S. W.","year":"2001","journal-title":"The Journal of Rheumatology"},{"key":"e_1_2_12_23_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.029033"},{"key":"e_1_2_12_24_2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/130854"},{"key":"e_1_2_12_25_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20236008"},{"key":"e_1_2_12_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2004.01.007"},{"key":"e_1_2_12_27_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00170.2003"},{"key":"e_1_2_12_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2009.01.072"},{"key":"e_1_2_12_29_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-9-18"},{"key":"e_1_2_12_30_2","article-title":"C-reactive protein: an inflammatory marker with specific role in physiology, pathology, and diagnosis","volume":"2","author":"Chandrashekara S.","year":"2014","journal-title":"Internet Journal of Rheumatology and Clinical Immunology"},{"key":"e_1_2_12_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-015-5597-x"},{"key":"e_1_2_12_32_2","article-title":"Early-onset coronary artery disease clinical and hereditary aspects","volume":"64","author":"Christiansen M. K.","year":"2017","journal-title":"Danish Medical Journal"},{"key":"e_1_2_12_33_2","doi-asserted-by":"publisher","DOI":"10.4103\/ejode.ejode_12_20"},{"key":"e_1_2_12_34_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.540492"},{"key":"e_1_2_12_35_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1107477"},{"key":"e_1_2_12_36_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dev025"},{"key":"e_1_2_12_37_2","doi-asserted-by":"publisher","DOI":"10.1177\/1933719115572478"},{"key":"e_1_2_12_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2016.11.007"},{"key":"e_1_2_12_39_2","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eux189"},{"key":"e_1_2_12_40_2","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13988"},{"key":"e_1_2_12_41_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11596-010-0557-7"},{"key":"e_1_2_12_42_2","doi-asserted-by":"publisher","DOI":"10.32771\/inajog.v37i2.344"},{"key":"e_1_2_12_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.03.021"},{"key":"e_1_2_12_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2018.10.011"},{"key":"e_1_2_12_45_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0108494"},{"key":"e_1_2_12_46_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2005.00639.x"},{"key":"e_1_2_12_47_2","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.170020"},{"key":"e_1_2_12_48_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0003331"},{"key":"e_1_2_12_49_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2016.95"},{"key":"e_1_2_12_50_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00475"},{"key":"e_1_2_12_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2015.05.002"},{"key":"e_1_2_12_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2016.08.007"},{"key":"e_1_2_12_53_2","doi-asserted-by":"publisher","DOI":"10.1161\/hc0902.104353"},{"key":"e_1_2_12_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.07.064"},{"key":"e_1_2_12_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hfc.2012.06.012"},{"key":"e_1_2_12_56_2","first-page":"29","article-title":"Serum levels of interleukin (IL)-33 in patients with ischemic heart disease","volume":"6","author":"Jafarinia M.","year":"2018","journal-title":"MOJ Immunology"},{"key":"e_1_2_12_57_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mca.0000236288.94553.b4"},{"key":"e_1_2_12_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2014.09.004"},{"key":"e_1_2_12_59_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000130484.20501.df"},{"key":"e_1_2_12_60_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.21.2531"},{"key":"e_1_2_12_61_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.18.2165"},{"key":"e_1_2_12_62_2","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2011.169839"},{"key":"e_1_2_12_63_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201412052"},{"key":"e_1_2_12_64_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000096055.62724.C5"},{"key":"e_1_2_12_65_2","doi-asserted-by":"publisher","DOI":"10.1111\/apha.12466"},{"key":"e_1_2_12_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2007.04.027"},{"key":"e_1_2_12_67_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.20.9.2094"},{"key":"e_1_2_12_68_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000081637.36475.BC"},{"key":"e_1_2_12_69_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0016470"},{"key":"e_1_2_12_70_2","doi-asserted-by":"publisher","DOI":"10.2131\/jts.28.439"},{"key":"e_1_2_12_71_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.2009.02037.x"},{"key":"e_1_2_12_72_2","doi-asserted-by":"publisher","DOI":"10.2174\/092986708783955455"},{"key":"e_1_2_12_73_2","doi-asserted-by":"publisher","DOI":"10.2174\/138161209787846702"},{"key":"e_1_2_12_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5273(02)00300-5"},{"key":"e_1_2_12_75_2","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2001.110"},{"key":"e_1_2_12_76_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(01)00696-9"},{"key":"e_1_2_12_77_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-005-1588-y"},{"key":"e_1_2_12_78_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2005.tb00108.x"},{"key":"e_1_2_12_79_2","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2891-14-6"},{"key":"e_1_2_12_80_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-016-9799-0"},{"key":"e_1_2_12_81_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199707243370403"},{"key":"e_1_2_12_82_2","first-page":"155","article-title":"The pathophysiological hypothesis of homocysteine thiolactone-mediated vascular disease","volume":"59","author":"Jakubowski H.","year":"2008","journal-title":"Journal of Physiology and Pharmacology"},{"key":"e_1_2_12_83_2","doi-asserted-by":"publisher","DOI":"10.3390\/biom10030393"},{"key":"e_1_2_12_84_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39000.486701.68"},{"key":"e_1_2_12_85_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2005.12.014"},{"key":"e_1_2_12_86_2","doi-asserted-by":"publisher","DOI":"10.2174\/0929867321666140706142335"},{"key":"e_1_2_12_87_2","doi-asserted-by":"publisher","DOI":"10.1161\/hc4601.098514"},{"key":"e_1_2_12_88_2","first-page":"73","article-title":"IL-17 patterns in synovium, serum and synovial fluid from treatment-naive, early rheumatoid arthritis patients","volume":"53","author":"Rosu A.","year":"2012","journal-title":"Romanian Journal of Morphology and Embryology"},{"key":"e_1_2_12_89_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2013.07.021"},{"key":"e_1_2_12_90_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0802246"},{"key":"e_1_2_12_91_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2008.00628.x"},{"key":"e_1_2_12_92_2","doi-asserted-by":"publisher","DOI":"10.1186\/ar2392"},{"key":"e_1_2_12_93_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-009-1179-x"},{"key":"e_1_2_12_94_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-010-9369-6"},{"key":"e_1_2_12_95_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2011.01308.x"},{"key":"e_1_2_12_96_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs399"},{"key":"e_1_2_12_97_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2008.01.009"},{"key":"e_1_2_12_98_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.109.145094"},{"key":"e_1_2_12_99_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.690081"},{"key":"e_1_2_12_100_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0040641"},{"key":"e_1_2_12_101_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.261784"},{"key":"e_1_2_12_102_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1102-1227"},{"key":"e_1_2_12_103_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000147228.29325.F9"},{"key":"e_1_2_12_104_2","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12589"},{"key":"e_1_2_12_105_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-18224-x"},{"key":"e_1_2_12_106_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.12.879"},{"key":"e_1_2_12_107_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.16299"},{"key":"e_1_2_12_108_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.111.231431"},{"key":"e_1_2_12_109_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13017-019-0256-z"},{"key":"e_1_2_12_110_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0095055"},{"key":"e_1_2_12_111_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2011.02.005"},{"key":"e_1_2_12_112_2","first-page":"6184","article-title":"Study on the effects of IL-33\/ST2 signaling pathway on spinal cord ischemia-reperfusion injury of rats","volume":"10","author":"Fan M.","year":"2017","journal-title":"International Journal of Clinical and Experimental Medicine"},{"key":"e_1_2_12_113_2","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.2004.029827"},{"key":"e_1_2_12_114_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvy166"}],"container-title":["Mediators of Inflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2021\/3425560.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2021\/3425560.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2021\/3425560","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T09:13:58Z","timestamp":1756372438000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2021\/3425560"}},"subtitle":[],"editor":[{"given":"Eduardo","family":"Dalmarco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":114,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1155\/2021\/3425560"],"URL":"https:\/\/doi.org\/10.1155\/2021\/3425560","archive":["Portico"],"relation":{},"ISSN":["0962-9351","1466-1861"],"issn-type":[{"value":"0962-9351","type":"print"},{"value":"1466-1861","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"2021-07-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"3425560"}}