{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T15:10:03Z","timestamp":1793286603655,"version":"4.5.0"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T00:00:00Z","timestamp":1612915200000},"content-version":"vor","delay-in-days":40,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009377","name":"Education Department of Hunan Province","doi-asserted-by":"publisher","award":["18A098"],"award-info":[{"award-number":["18A098"]}],"id":[{"id":"10.13039\/100009377","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2019JJ40134"],"award-info":[{"award-number":["2019JJ40134"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>\n                    A high\u2010fat diet (HFD) has been previously associated with the development of diseases such as chronic colitis. While chlorogenic acid (CGA) is known to exhibit potent antioxidant, antibacterial, and anti\u2010inflammatory properties, little is known about its effects on intestinal inflammation. In this study, we investigated the effects of CGA on intestinal inflammation in an HFD\u2010induced obesity rat model and assessed whether these effects were related to changes in gut microbiota composition. This was achieved by examining physiological and biochemical indicators, the liver transcriptome, and the structure of the fecal microflora. CGA treatment significantly reduced HFD\u2010induced internal organ weight gain, promoted colon tissue repair, downregulated the expression of inflammatory cytokines, and promoted the accumulation of the tight junction protein. KEGG enrichment analysis of differentially expressed genes, applied to data from the RNA\u2010seq of rat liver tissue, revealed that CGA treatment significantly affected amino acid and lipid metabolism in the liver. Furthermore, CGA decreased the abundance of bacteria belonging to the genera\n                    <jats:italic>Blautia<\/jats:italic>\n                    ,\n                    <jats:italic>Sutterella<\/jats:italic>\n                    , and\n                    <jats:italic>Akkermansia<\/jats:italic>\n                    and increased butyric acid levels, which were positively correlated with\n                    <jats:italic>the abundance of Ruminococcus<\/jats:italic>\n                    (butyric acid producer). Moreover, the beneficial changes observed in the HFD group were not as pronounced as those in the CGA treatment group. In summary, CGA can alleviate colitis in HFD\u2010induced obesity through its anti\u2010inflammatory effects associated with changes in gut microbiota composition and an increase in the production of short\u2010chain fatty acids and thus can be used as a potential drug for the treatment of this pathology.\n                  <\/jats:p>","DOI":"10.1155\/2021\/3456542","type":"journal-article","created":{"date-parts":[[2021,2,11]],"date-time":"2021-02-11T02:59:30Z","timestamp":1613012370000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["Chlorogenic Acid Alleviates Colon Mucosal Damage Induced by a High\u2010Fat Diet via Gut Microflora Adjustment to Increase Short\u2010Chain Fatty Acid Accumulation in Rats"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7651-461X","authenticated-orcid":false,"given":"M. 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