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A multikinase inhibitor, vandetanib, prolongs the progression\u2010free survival time in advanced medullary thyroid cancer. However, vandetanib has been reported to induce significant QT interval prolongation, which limits its clinical application. Some studies have showed that ginsenoside Rg3 decelerated hERG K(+) channel tail current deactivation. Therefore, in this study, we aim to confirm whether ginsenoside Rg3 targeting hERG K(+) channel could be used to reverse the vandetanib\u2010induced QT interval prolongation. Electrocardiogram (ECG) and monophasic action potential (MAP) were recorded using electrophysiology signal sampling and analysis system in Langendorff\u2010perfused rabbit hearts. The current clamp mode of the patch\u2010clamp technique was used to record transmembrane action potential. The whole\u2010cell patch\u2010clamp technique was used to record the hERG K<jats:sup>+<\/jats:sup> current. In Langendorff\u2010perfused hearts, vandetanib prolonged the QT interval in a concentration\u2010dependent manner with an IC<jats:sub>50<\/jats:sub> of 1.96\u2009<jats:italic>\u03bc<\/jats:italic>mol\/L. In human\u2010induced pluripotent stem cell\u2010derived cardiomyocytes (hiPSC\u2010CMs), vandetanib significantly prolonged the action potential duration at 50%, 70%, and 90% repolarization (APD<jats:sub>50<\/jats:sub>, APD<jats:sub>70<\/jats:sub>, and APD<jats:sub>90<\/jats:sub>). In stable transfected human hERG gene HEK293 cells, vandetanib caused concentrate\u2010dependent inhibition in the step and tail currents of hERG. As expected, ginsenoside Rg3 relieved vandetanib\u2010induced QT interval prolongation in Langendorff\u2010perfused heart and reversed vandetanib\u2010induced APD prolongation in hiPSC\u2010CMs. Furthermore, ginsenoside Rg3 alleviated vandetanib\u2010induced hERG current inhibition and accelerated the process of the channel activation. Ginsenoside Rg3 may be a promising cardioprotective agent against vandetanib\u2010induced QT interval prolongation through targeting hERG channel. These novel findings highlight the therapeutic potential of ginsenoside to prevent vandetanib\u2010induced cardiac arrhythmia.<\/jats:p>","DOI":"10.1155\/2021\/3520034","type":"journal-article","created":{"date-parts":[[2021,10,10]],"date-time":"2021-10-10T17:57:07Z","timestamp":1633888627000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["[Retracted] Ginsenoside Rg3 Alleviates Antithyroid Cancer Drug Vandetanib\u2010Induced QT Interval Prolongation"],"prefix":"10.1155","volume":"2021","author":[{"given":"Juan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiyi","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoli","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1041-1500","authenticated-orcid":false,"given":"Lin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5019-4232","authenticated-orcid":false,"given":"Miaoling","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,10,7]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.3803\/EnM.2021.1082"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1358\/dot.2010.46.9.1516989"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA119.007682"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-14-0788"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.48.4659"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-15-1127"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/1060028013512791"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.4137\/CMO.S6197"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/2042018811419889"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0030353"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2017.07.006"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2010.08.026"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00036.2011"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12859-019-2814-5"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2020.112290"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2019.01.029"},{"key":"e_1_2_9_17_2","volume-title":"Seminars in Cancer Biology","author":"Fallahi P.","year":"2020"},{"key":"e_1_2_9_18_2","first-page":"3459","article-title":"Selective use of vandetanib in the treatment of thyroid cancer","volume":"9","author":"Fallahi P.","year":"2015","journal-title":"Drug Design, Development and Therapy"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.EJ20-0171"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.2174\/157488610789869247"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2006.03.026"},{"key":"e_1_2_9_22_2","doi-asserted-by":"crossref","unstructured":"LeeH. 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