{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T07:21:42Z","timestamp":1767165702491,"version":"build-2238731810"},"reference-count":28,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,9,28]],"date-time":"2021-09-28T00:00:00Z","timestamp":1632787200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Healthcare Engineering"],"published-print":{"date-parts":[[2021,9,28]]},"abstract":"<jats:p>\n                    Background. This study aims to analyze the influence of different dexmedetomidine doses on cognitive function. It works on early periods of patients undergoing laparoscopic extensive total hysterectomy. Method. 119 patients with gynecological cancer underwent a laparoscopic extensive total hysterectomy. The operation was performed at the Affiliated Women\u2019s and Children\u2019s Hospital of Xiamen University from January 2019 to June 2020. The score of MoCA and the level of TNF-\u03b1, IL-6, S-100\u03b2 protein, NSE, and GFAP of each group were compared 1 day before and after operation and 3 and 7 days after operation. Result. In four groups, remifentanil, sufentanil, and propofol were given in the following order: group A\u2009&gt;\u2009group D\u2009&gt;\u2009group C\u2009&gt;\u2009group B. Group A\u2009&gt;\u2009group D\u2009&gt;\u2009group C in terms of time spent in the recovery room, extubation, and recovery from anesthesia. The difference between groups B and C was not significant (\n                    <jats:inline-formula>\n                      <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>&gt;<\/a:mo>\n                        <a:mn>0.05<\/a:mn>\n                      <\/a:math>\n                    <\/jats:inline-formula>\n                    ). Compared with group A, group B scored higher in MoCA at 1 day (T1), 3 days (T2), and 7 days (T3) after operation (\n                    <jats:inline-formula>\n                      <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>P<\/c:mi>\n                        <c:mo>&lt;<\/c:mo>\n                        <c:mn>0.05<\/c:mn>\n                      <\/c:math>\n                    <\/jats:inline-formula>\n                    ). At the same scoring point, the score was group B\u2009&gt;\u2009group C\u2009&gt;\u2009group D\u2009&gt;\u2009group A. The POCD of four groups all occurred at 3 days after surgery. Compared with the T0 point, the level of TNF-\u03b1 and IL-6 of the four groups at T1 and T2 was significantly increased (\n                    <jats:inline-formula>\n                      <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>P<\/e:mi>\n                        <e:mo>&lt;<\/e:mo>\n                        <e:mn>0.05<\/e:mn>\n                      <\/e:math>\n                    <\/jats:inline-formula>\n                    ). At T3, the level of TNF-\u03b1 and IL-6 gradually decreased. At various periods, the levels of S-100 protein, NSE, and GFAP in groups B, C, and D were lower than those in group A (P0.05). Group B had a substantially higher rate of bradycardia than the other three groups (P0.05). The incidence of chills, respiratory depression, and restlessness in group A differed significantly from the other three groups (\n                    <jats:inline-formula>\n                      <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>P<\/g:mi>\n                        <g:mo>&lt;<\/g:mo>\n                        <g:mn>0.05<\/g:mn>\n                      <\/g:math>\n                    <\/jats:inline-formula>\n                    ). Conclusion. Using 0.5\u2009\u03bcg\/kg dexmedetomidine during the perianaesthesia can effectively reduce anesthetic drugs in patients. They had a laparoscopic extensive complete hysterectomy, which helps to reduce the adverse responses and the occurrence of POCD while also protecting brain function.\n                  <\/jats:p>","DOI":"10.1155\/2021\/3531199","type":"journal-article","created":{"date-parts":[[2021,9,28]],"date-time":"2021-09-28T16:43:46Z","timestamp":1632847426000},"page":"1-9","source":"Crossref","is-referenced-by-count":7,"title":["The Influence of Different Dexmedetomidine Doses on Cognitive Function at Early Period of Patients Undergoing Laparoscopic Extensive Total Hysterectomy"],"prefix":"10.1155","volume":"2021","author":[{"given":"Huiqiong","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Women and Children\u2019s Hospital, School of Medicine, Xiamen University, Xiamen, Fujian, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuyi","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Women and Children\u2019s Hospital, School of Medicine, Xiamen University, Xiamen, Fujian, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yirong","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, 907th Hospital of the Joint Logistics Support Force of the Chinese People\u2019s Liberation Army, Nanping, Fujian, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5574-0589","authenticated-orcid":true,"given":"Junxiang","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Women and Children\u2019s Hospital, School of Medicine, Xiamen University, Xiamen, Fujian, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-018-0873-z"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2017.1505"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2019.10438"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1097\/md.0000000000015383"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1097\/cm9.0000000000000098"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2018.6180"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1111\/neup.12530"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.4103\/jcrt.JCRT_164_18"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.0234"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2019.10611"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1590\/s0102-865020190090000005"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2018.5806"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1111\/anae.14606"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1177\/1559325820902345"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1177\/0300060516671623"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2019.10675"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2018.6778"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.2217\/pme-2019-0003"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2017.5589"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.18502\/jthc.v14i2.1374"},{"issue":"5","key":"21","first-page":"1106","article-title":"Influence of dexmedetomidine to cognitive function during recovery period for children with general anesthesia","volume":"21","author":"Z. 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