{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T11:47:23Z","timestamp":1767008843222,"version":"3.41.2"},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T00:00:00Z","timestamp":1611792000000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["RG\/2011\/HS\/13"],"award-info":[{"award-number":["RG\/2011\/HS\/13"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009826","name":"University of Colombo","doi-asserted-by":"publisher","award":["AP\/3\/2\/2014\/RG\/13"],"award-info":[{"award-number":["AP\/3\/2\/2014\/RG\/13"]}],"id":[{"id":"10.13039\/501100009826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>Sri Lanka reports a large focus of <jats:italic>Leishmania donovani<\/jats:italic>\u2010induced cutaneous leishmaniasis (CL) with CL as the main clinical entity. Two independent, long existed, and clinicoepidemiologically different transmission foci in the northern region (NR) and southern region (SR) were recently reported. Current project is an extension to this previous study. Clinical diversity within a profile of classical cutaneous leishmaniasis (CCL) in a focus of <jats:italic>L. donovani<\/jats:italic>\u2010induced CL is described for the first time. Patients with laboratory confirmed CCL (<jats:italic>n<\/jats:italic> = 550) from NF and SF were evaluated. Lesions in both foci were found to have all classical developmental stages (small and large nodules, ulcerating nodules, and ulcers) and other identified changes (multiplication, ulceration, and enlargement). Main difference was in the proportions of lesions progressing in to each different stages, proportions of lesion undergoing the main changes, and in timing of these changes during the course of a lesion. Northern focus reported a smaller proportion of lesions showing enlargement and ulceration, and a longer period of time was also required for these changes when compared to same in southern focus. In northern focus, most lesions remained small and nonulcerating and showed a higher tendency to multiply while most lesions reported in southern focus enlarged and ulcerated rapidly and remained single. Current study also evidenced a wider spectrum in the rate and pattern of progression of a skin lesion and high individual variation which could mask these region\u2010based differences. Parasitic, vector\u2010related, or a host etiology is suggested. Slow progressing nonulcerating infections in North may be the result of a well\u2010adopted parasite strain that coevolved with its host for a long period while inducing only a minimal host response. This could be one among many reasons for previously observed silent expansion in northern focus while southern focus remained more confined and stable over time. Small nonprogressive, nondisturbing lesions can play a major role as silent parasite reservoirs in a community. In addition, the laboratory detection rate declined significantly when lesions multiplied and enlarged indicating the need for early laboratory confirmation. Usefulness of identified features in clinical screening and management needs to be considered.<\/jats:p>","DOI":"10.1155\/2021\/3537968","type":"journal-article","created":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T20:20:25Z","timestamp":1611865225000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["First Evidence from Sri Lanka for Subphenotypic Diversity within <i>L. donovani<\/i>\u2010Induced Classical Cutaneous Leishmaniasis"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3283-0140","authenticated-orcid":false,"given":"Yamuna","family":"Siriwardana","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bhagya","family":"Deepachandi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sudath","family":"Weerasinghe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3985-1817","authenticated-orcid":false,"given":"Nadira","family":"Karunaweera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chandanie","family":"Udagedara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wipula","family":"Warnasuriya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ranthilaka R.","family":"Ranawaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Indira","family":"Kahawita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,1,28]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035671"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/sdata.2014.36"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/286408"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.15-0738"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.175930"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(16)30195-5"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2017.02.002"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.epidem.2017.01.002"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.4038\/cmj.v48i1.3386"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1303.060242"},{"key":"e_1_2_11_11_2","first-page":"799","article-title":"Cutaneous leishmaniasis in southern Sri Lanka","volume":"101","author":"Rajapaksa U. 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