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Long noncoding RNAs (lncRNAs) represent an important novel class of noncoding RNA molecule greater than 200 nucleotides that play a key role in the regulation of autoimmune diseases. Previous studies have demonstrated that MAFTRR (MAF transcriptional regulator RNA) regulated Th1 cells differentiation by inhibiting the expression of MAF in activated CD4+ T cells. However, the effect of MAFTRR on the pathogenesis of Hashimoto\u2019s thyroiditis (HT) remains unclear. This research was aimed at investigating the expression of MAFTRR in Hashimoto\u2019s thyroiditis (HT) as well as the correlation between MAFTRR and Th1 cells. Methods. Thirty-eight HT patients and thirty-eight healthy controls were enrolled in the study. The proportion of Th1 cells and CD8+IFN-\u03b3+ T cells in peripheral blood mononuclear cells (PBMCs) from these specimens was determined by flow cytometric analysis. The transcript levels of MAFTRR, MAF, and IFNG in PBMCs and thyroid glands were detected by quantitative real-time PCR. Receiver operating characteristic (ROC) curve analysis was performed to evaluate the potential value of MAFTRR in the HT patients. Results. We found that the proportion of circulating Th1 cells and the transcript levels of IFNG were increased in peripheral blood of the HT patients. The transcript levels of MAFTRR were significantly increased in the HT patients and positively correlated with the percentage of Th1 cells and serum levels of antithyroglobulin antibody and antithyroperoxidase antibody. The transcript levels of MAF, a transcription factor that inhibits Th1 cells activity and IFN-\u03b3 production, were attenuated in PBMCs from the HT patients. The transcript levels of IFNG had positive and inverse correlations with MAFTRR and MAF expression in PBMCs from the HT patients, respectively. Additionally, a significantly positive correlation between upregulated MAFTRR expression and augmented IFNG expression was revealed in thyroid tissues from the HT patients. ROC curve suggested that MAFTRR could potentially differentiate the HT patients from healthy controls. Conclusion. MAFTRR is significantly augmented in the HT patients and may contribute to the pathogenic role of the Th1 cells response in HT.<\/jats:p>","DOI":"10.1155\/2021\/3577011","type":"journal-article","created":{"date-parts":[[2021,11,27]],"date-time":"2021-11-27T05:50:06Z","timestamp":1637992206000},"page":"1-11","source":"Crossref","is-referenced-by-count":7,"title":["Elevated Expression of the Long Noncoding RNA MAFTRR in Patients with Hashimoto\u2019s Thyroiditis"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7247-8797","authenticated-orcid":true,"given":"Huiyong","family":"Peng","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, The Affiliated People\u2019s Hospital of Jiangsu University, Zhenjiang Medical School of Nanjing Medical University, Zhenjiang 212002, China"},{"name":"Department of Genetic Toxicology, The Key Laboratory of Modern Toxicology of Ministry of Education, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211100, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangmei","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The Affiliated People\u2019s Hospital of Jiangsu University, Zhenjiang Medical School of Nanjing Medical University, Zhenjiang 212002, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, The Affiliated People\u2019s Hospital of Jiangsu University, Zhenjiang Medical School of Nanjing Medical University, Zhenjiang 212002, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, The Affiliated People\u2019s Hospital of Jiangsu University, Zhenjiang Medical School of Nanjing Medical University, Zhenjiang 212002, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, The Affiliated People\u2019s Hospital of Jiangsu University, Zhenjiang Medical School of Nanjing Medical University, Zhenjiang 212002, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyi","family":"Tang","sequence":"additional","affiliation":[{"name":"Division of Hematology and Internal Medicine, Mayo Clinic, Rochester, MN 55902, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6584-1183","authenticated-orcid":true,"given":"Shengjun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, The Affiliated People\u2019s Hospital of Jiangsu University, Zhenjiang Medical School of Nanjing Medical University, Zhenjiang 212002, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6383-6345","authenticated-orcid":true,"given":"Yingzhao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The Affiliated People\u2019s Hospital of Jiangsu University, Zhenjiang Medical School of Nanjing Medical University, Zhenjiang 212002, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","article-title":"Genetic susceptibility to joint occurrence of polycystic ovary syndrome and Hashimoto\u2019s thyroiditis: how far is our understanding?","volume":"12, article 606620","author":"N. 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