{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T06:46:41Z","timestamp":1787813201969,"version":"build-2784847793"},"reference-count":68,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T00:00:00Z","timestamp":1631059200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Open Project of Shanghai Key Laboratory of Major Psychiatry","award":["20-K04"],"award-info":[{"award-number":["20-K04"]}]},{"name":"Open Project of Shanghai Key Laboratory of Major Psychiatry","award":["201711230065"],"award-info":[{"award-number":["201711230065"]}]},{"name":"Open Project of Shanghai Key Laboratory of Major Psychiatry","award":["LH2019H064"],"award-info":[{"award-number":["LH2019H064"]}]},{"name":"Open Project of Shanghai Key Laboratory of Major Psychiatry","award":["2019-KYYWF-1215"],"award-info":[{"award-number":["2019-KYYWF-1215"]}]},{"name":"Training Program of Innovation and Entrepreneurship for Undergraduates of Heilongjiang Province","award":["20-K04"],"award-info":[{"award-number":["20-K04"]}]},{"name":"Training Program of Innovation and Entrepreneurship for Undergraduates of Heilongjiang Province","award":["201711230065"],"award-info":[{"award-number":["201711230065"]}]},{"name":"Training Program of Innovation and Entrepreneurship for Undergraduates of Heilongjiang Province","award":["LH2019H064"],"award-info":[{"award-number":["LH2019H064"]}]},{"name":"Training Program of Innovation and Entrepreneurship for Undergraduates of Heilongjiang Province","award":["2019-KYYWF-1215"],"award-info":[{"award-number":["2019-KYYWF-1215"]}]},{"DOI":"10.13039\/501100005046","name":"Natural Science Foundation of Heilongjiang Province","doi-asserted-by":"publisher","award":["20-K04"],"award-info":[{"award-number":["20-K04"]}],"id":[{"id":"10.13039\/501100005046","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005046","name":"Natural Science Foundation of Heilongjiang Province","doi-asserted-by":"publisher","award":["201711230065"],"award-info":[{"award-number":["201711230065"]}],"id":[{"id":"10.13039\/501100005046","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005046","name":"Natural Science Foundation of Heilongjiang Province","doi-asserted-by":"publisher","award":["LH2019H064"],"award-info":[{"award-number":["LH2019H064"]}],"id":[{"id":"10.13039\/501100005046","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005046","name":"Natural Science Foundation of Heilongjiang Province","doi-asserted-by":"publisher","award":["2019-KYYWF-1215"],"award-info":[{"award-number":["2019-KYYWF-1215"]}],"id":[{"id":"10.13039\/501100005046","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003851","name":"Department of Education, Heilongjiang Province","doi-asserted-by":"publisher","award":["20-K04"],"award-info":[{"award-number":["20-K04"]}],"id":[{"id":"10.13039\/501100003851","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003851","name":"Department of Education, Heilongjiang Province","doi-asserted-by":"publisher","award":["201711230065"],"award-info":[{"award-number":["201711230065"]}],"id":[{"id":"10.13039\/501100003851","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003851","name":"Department of Education, Heilongjiang Province","doi-asserted-by":"publisher","award":["LH2019H064"],"award-info":[{"award-number":["LH2019H064"]}],"id":[{"id":"10.13039\/501100003851","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003851","name":"Department of Education, Heilongjiang Province","doi-asserted-by":"publisher","award":["2019-KYYWF-1215"],"award-info":[{"award-number":["2019-KYYWF-1215"]}],"id":[{"id":"10.13039\/501100003851","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neural Plasticity"],"published-print":{"date-parts":[[2021,9,8]]},"abstract":"<jats:p>Background. Previous studies explored the whole-brain functional connectome using the degree approach in patients with obsessive-compulsive disorder (OCD). However, whether the altered degree values can be used to discriminate OCD from healthy controls (HCs) remains unclear. Methods. A total of 40 medication-free patients with OCD and 38 HCs underwent a resting-state functional magnetic resonance imaging (rs-fMRI) scan. Data were analyzed with the degree approach and a support vector machine (SVM) classifier. Results. Patients with OCD showed increased degree values in the left thalamus and left cerebellum Crus I and decreased degree values in the left dorsolateral prefrontal cortex, right precuneus, and left postcentral gyrus. SVM classification analysis indicated that the increased degree value in the left thalamus is a marker of OCD, with an acceptable accuracy of 88.46%, sensitivity of 87.50%, and specificity of 89.47%. Conclusion. Altered degree values within and outside the cortical-striatal-thalamic-cortical (CSTC) circuit may cocontribute to the pathophysiology of OCD. Increased degree values of the left thalamus can be used as a future marker for OCD understanding-classification.<\/jats:p>","DOI":"10.1155\/2021\/3741104","type":"journal-article","created":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T19:05:09Z","timestamp":1631127909000},"page":"1-9","source":"Crossref","is-referenced-by-count":13,"title":["Altered Functional Connectivity Strength at Rest in Medication-Free Obsessive-Compulsive Disorder"],"prefix":"10.1155","volume":"2021","author":[{"given":"Dan","family":"Lv","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Qiqihar Medical University, Qiqihar, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangpan","family":"Ou","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Mental Disorders and Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhua","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Qiqihar Medical University, Qiqihar, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jidong","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Baiyupao Psychiatric Hospital of Harbin, Harbin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuang","family":"Zhan","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Baiyupao Psychiatric Hospital of Harbin, Harbin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ru","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Radiology, The Second Xiangya Hospital of Central South University, Changsha, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunhui","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Qiqihar Medical University, Qiqihar, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tinghuizi","family":"Shang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Qiqihar Medical University, Qiqihar, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuicui","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Qiqihar Medical University, Qiqihar, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Qiqihar Medical University, Qiqihar, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangfeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology, The Third Affiliated Hospital of Qiqihar Medical University, Qiqihar, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenghai","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Qiqihar Medical University, Qiqihar, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Qiqihar Medical University, Qiqihar, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoping","family":"Wang","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Mental Disorders and Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1626-2465","authenticated-orcid":true,"given":"Wenbin","family":"Guo","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Mental Disorders and Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3241-3091","authenticated-orcid":true,"given":"Ping","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Qiqihar Medical University, Qiqihar, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.comppsych.2009.10.001"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2008.94"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1177\/0004867418806370"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2019.134449"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpsy.2018.01.005"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1017\/s0033291719002988"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2018.10.112"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2016.07.004"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0000000000001460"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1007\/s11571-019-09553-w"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2017.04.002"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1017\/s0033291720003980"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2019.111982"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1093\/scan\/nsm006"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0021976"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.4103\/0366-6999.170269"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2016.03.017"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-33-6044-0_3"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2018.08.006"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291720003141"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2013.173"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsycho.2015.09.004"},{"issue":"1","key":"23","article-title":"Applications of support vector machine (SVM) learning in cancer genomics","volume":"15","author":"S. Huang","year":"2018","journal-title":"Cancer Genomics & Proteomics"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1016\/j.inffus.2020.09.002"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1016\/j.cviu.2010.09.007"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2014.2377694"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1007\/s12021-016-9299-4"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23596"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2018.04.076"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.10.018"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5062-08.2009"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1177\/0004867414553949"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.05.005"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2019.3671"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2019.02.057"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2019.00319"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1080\/24750573.2019.1583481"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1503\/jpn.130220"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2017.04.012"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2018.11.080"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2002.1280"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2004.12.016"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2015.12.014"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.963"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2019.00452"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1111\/sjop.12066"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2019.00099"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0067262"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2019.00522"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-019-01070-5"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpsc.2019.12.002"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.11.023"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpsy.2017.08.001"},{"key":"54","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.03.004"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpsycho.2014.02.007"},{"key":"56","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2019.00418"},{"key":"57","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S117510"},{"key":"58","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291715002330"},{"key":"59","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2013.09.002"},{"key":"60","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3475"},{"key":"61","doi-asserted-by":"publisher","DOI":"10.1017\/s0033291719001090"},{"key":"62","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpsc.2018.01.009"},{"key":"63","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2013.10.021"},{"key":"64","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2019.04.016"},{"key":"65","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2018.06.001"},{"key":"66","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-80346-6"},{"key":"67","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2007.11.031"},{"key":"68","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2019.03.008"}],"container-title":["Neural Plasticity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/np\/2021\/3741104.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/np\/2021\/3741104.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/np\/2021\/3741104.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T19:05:14Z","timestamp":1631127914000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/np\/2021\/3741104\/"}},"subtitle":[],"editor":[{"given":"Sergio","family":"Bagnato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,9,8]]},"references-count":68,"alternative-id":["3741104","3741104"],"URL":"https:\/\/doi.org\/10.1155\/2021\/3741104","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.740850286.793589650","asserted-by":"object"}]},"ISSN":["1687-5443","2090-5904"],"issn-type":[{"value":"1687-5443","type":"electronic"},{"value":"2090-5904","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9,8]]}}}