{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T14:56:24Z","timestamp":1746802584855,"version":"3.40.5"},"reference-count":27,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T00:00:00Z","timestamp":1632960000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["FISS PI 13\/02119"],"award-info":[{"award-number":["FISS PI 13\/02119"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Oncology"],"published-print":{"date-parts":[[2021,9,30]]},"abstract":"<jats:p>Background. The influence of HLA class I and II loci on the susceptibility to melanoma remains an area of intense debate. This study aimed to examine whether the HLA system was related to melanoma susceptibility and prognosis in a southern Spanish population. Methods. In this study, HLA class I and class II genotyping were performed using polymerase chain reaction sequence-specific oligonucleotides (PCR-SSO) in 237 Spanish melanoma patients and 636 ethnically matched controls. Data were analyzed according to the clinical characteristics of the defined subgroups. Results. Compared to the control group, DRB1<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <a:mi>\u2217<\/a:mi>\n                     <\/a:math>\n                  <\/jats:inline-formula>16:01 (4% vs. 1.3%, <jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <c:mi>p<\/c:mi>\n                        <c:mo>=<\/c:mo>\n                        <c:mn>0.001<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>, Pc\u2009=\u20090.035, OR\u2009=\u20093.28) and DQB1<jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <e:mi>\u2217<\/e:mi>\n                     <\/e:math>\n                  <\/jats:inline-formula>05:02 (4.9% vs. 2%, <jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\">\n                        <g:mi>p<\/g:mi>\n                        <g:mo>=<\/g:mo>\n                        <g:mn>0.001<\/g:mn>\n                     <\/g:math>\n                  <\/jats:inline-formula>, Pc\u2009=\u20090.017, OR\u2009=\u20092.54) were positivity associated with the susceptibility to melanoma. Both DRB1<jats:inline-formula>\n                     <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\">\n                        <i:mi>\u2217<\/i:mi>\n                     <\/i:math>\n                  <\/jats:inline-formula>16:01 (5.4% vs. 1.3%, <jats:inline-formula>\n                     <k:math xmlns:k=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\">\n                        <k:mi>p<\/k:mi>\n                        <k:mo>=<\/k:mo>\n                        <k:mn>0.001<\/k:mn>\n                     <\/k:math>\n                  <\/jats:inline-formula>, Pc\u2009=\u20090.035, OR\u2009=\u20094.46) and DQB1<jats:inline-formula>\n                     <m:math xmlns:m=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M9\">\n                        <m:mi>\u2217<\/m:mi>\n                     <\/m:math>\n                  <\/jats:inline-formula>05:02 (6.5% vs. 2%, <jats:inline-formula>\n                     <o:math xmlns:o=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M10\">\n                        <o:mi>p<\/o:mi>\n                        <o:mo>=<\/o:mo>\n                        <o:mn>0.001<\/o:mn>\n                     <\/o:math>\n                  <\/jats:inline-formula>, Pc\u2009=\u20090.017, OR\u2009=\u20093.44) also showed a positive correlation with Breslow thickness &gt;1.5\u2009mm, most notably at an early age of diagnosis (\u226458 years), DRB1<jats:inline-formula>\n                     <q:math xmlns:q=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M11\">\n                        <q:mi>\u2217<\/q:mi>\n                     <\/q:math>\n                  <\/jats:inline-formula>16:01 (4.2% vs. 1.3%, <jats:inline-formula>\n                     <s:math xmlns:s=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M12\">\n                        <s:mi>p<\/s:mi>\n                        <s:mo>=<\/s:mo>\n                        <s:mn>0.001<\/s:mn>\n                     <\/s:math>\n                  <\/jats:inline-formula>, Pc\u2009=\u20090.035, OR\u2009=\u20093.41) and DQB1<jats:inline-formula>\n                     <u:math xmlns:u=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M13\">\n                        <u:mi>\u2217<\/u:mi>\n                     <\/u:math>\n                  <\/jats:inline-formula>05:02 (5.4% vs. 2%, <jats:inline-formula>\n                     <w:math xmlns:w=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M14\">\n                        <w:mi>p<\/w:mi>\n                        <w:mo>=<\/w:mo>\n                        <w:mn>0.002<\/w:mn>\n                     <\/w:math>\n                  <\/jats:inline-formula>, Pc\u2009=\u20090.034, OR\u2009=\u20092.86). Conclusion. These findings established HLA-DRB1<jats:inline-formula>\n                     <y:math xmlns:y=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M15\">\n                        <y:mi>\u2217<\/y:mi>\n                     <\/y:math>\n                  <\/jats:inline-formula>16:01 and HLA-DQB1<jats:inline-formula>\n                     <ab:math xmlns:ab=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M16\">\n                        <ab:mi>\u2217<\/ab:mi>\n                     <\/ab:math>\n                  <\/jats:inline-formula>05:02 loci as melanoma risk factors in the southern Spanish population.<\/jats:p>","DOI":"10.1155\/2021\/3801143","type":"journal-article","created":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T20:10:46Z","timestamp":1633032646000},"page":"1-7","source":"Crossref","is-referenced-by-count":4,"title":["HLA-DRB1<a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                     <a:mi>\u2217<\/a:mi>\n                  <\/a:math>16:01 and HLA-DQB1<c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                     <c:mi>\u2217<\/c:mi>\n                  <\/c:math>05:02 Alleles Influence the Susceptibility and Progression of Cutaneous Malignant Melanoma"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4964-9460","authenticated-orcid":true,"given":"Xu","family":"Wang","sequence":"first","affiliation":[{"name":"Servicio de An\u00e1lisis Cl\u00ednicos e Inmunolog\u00eda, Hospital Universitario Virgen de las Nieves, Avda. Fuerzas Armadas s\/n, Granada 18014, Spain"},{"name":"Programa de Doctorado en Biomedicina, Universidad de Granada, Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0000-1885","authenticated-orcid":true,"given":"Francisco","family":"Almazan","sequence":"additional","affiliation":[{"name":"Programa de Doctorado en Biomedicina, Universidad de Granada, Granada, Spain"},{"name":"Servicio de Dermatolog\u00eda, Hospital Universitario Clinico San Cecilio (PTS), Av. de la Investigaci\u00f3n, s\/n, Granada 18016, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3169-0924","authenticated-orcid":true,"given":"Yoel Genaro","family":"Montoyo-Pujol","sequence":"additional","affiliation":[{"name":"Servicio de An\u00e1lisis Cl\u00ednicos e Inmunolog\u00eda, Hospital Universitario Virgen de las Nieves, Avda. Fuerzas Armadas s\/n, Granada 18014, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonia","family":"Martin-Casares","sequence":"additional","affiliation":[{"name":"Servicio de An\u00e1lisis Cl\u00ednicos e Inmunolog\u00eda, Hospital Universitario Virgen de las Nieves, Avda. Fuerzas Armadas s\/n, Granada 18014, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aurelio","family":"Martin","sequence":"additional","affiliation":[{"name":"Servicio de Anatom\u00eda Patol\u00f3gica, Hospital Universitario Virgen de las Nieves, Avda. 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GRANADA, Avda de Madrid 15, Pabell\u00f3n de Consultas Externas 2, Granada 18012, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1007\/s002620050589"},{"key":"2","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1177\/030089160108700509","article-title":"Impaired perforin-dependent NK cell cytotoxicity and proliferative activity of peripheral blood T cells is associated with metastatic melanoma","volume":"87","author":"V. 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Mervic","year":"2012","journal-title":"Acta Dermatovenerologica Alpina Pannonica et Adriatica"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2009.23.4799"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1245\/aso.2004.04.015"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1111\/tan.13644"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.12406"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2010.01578.x"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-007-0300-9"}],"container-title":["Journal of Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jo\/2021\/3801143.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jo\/2021\/3801143.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jo\/2021\/3801143.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T20:10:51Z","timestamp":1633032651000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/jo\/2021\/3801143\/"}},"subtitle":[],"editor":[{"given":"Jimei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2021,9,30]]},"references-count":27,"alternative-id":["3801143","3801143"],"URL":"https:\/\/doi.org\/10.1155\/2021\/3801143","relation":{},"ISSN":["1687-8469","1687-8450"],"issn-type":[{"type":"electronic","value":"1687-8469"},{"type":"print","value":"1687-8450"}],"subject":[],"published":{"date-parts":[[2021,9,30]]}}}