{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:43:34Z","timestamp":1791398614974,"version":"4.3.3"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,12,31]],"date-time":"2021-12-31T00:00:00Z","timestamp":1640908800000},"content-version":"vor","delay-in-days":364,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81900522"],"award-info":[{"award-number":["81900522"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>Nonalcoholic steatohepatitis (NASH) is a progressive, chronic liver disease worldwide which imposes a large economic burden on society. M1\/M2 macrophage balance destruction and recruitment of mononuclear immune cells to the liver play critical roles in NASH. Several studies have shown that the expression of TNF\u2010like ligand 1 aberrance (TL1A) increased in macrophages associated with many inflammatory diseases, for example, inflammatory bowel disease, primary biliary cholangitis, and liver fibrosis. One recent research showed that weight, abdominal adipose, and liver leptin, one of the critical fat cytokines, were reduced in <jats:italic>TL1A<\/jats:italic> knockout mice. However, the functional and molecular regulatory mechanisms of TL1A on macrophage polarization and recruitment in NASH have yet to be clarified. The authors found that high fructose high fat diet and methionine\u2010choline deficiency diet induced the expression of TL1A in macrophages of liver tissue from murine NASH models. Myeloid\u2010specific TL1A overexpressed mice showed exacerbated steatohepatitis with increased hepatic lipid accumulation, inflammation, liver injury, and apoptosis. M1 macrophages\u2019 infiltration and the production of proinflammatory and chemotactic cytokines increased in liver of NASH mouse models with myeloid\u2010specific TL1A overexpressed. Furthermore, this paper revealed that bone marrow\u2010derived macrophages and Kupffer cells with overexpression of TL1A exacerbated the lipid accumulation and expression of proinflammatory factors in the murine primary hepatocytes after free fatty acid treatment <jats:italic>in vitro<\/jats:italic>. In conclusion, TL1A\u2010mediated M1\u2010type macrophage polarization and recruitment into the liver promoted steatohepatitis in murine NASH.<\/jats:p>","DOI":"10.1155\/2021\/3877617","type":"journal-article","created":{"date-parts":[[2021,12,31]],"date-time":"2021-12-31T20:20:24Z","timestamp":1640982024000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["TNF\u2010Like Ligand 1 Aberrance Aggravates Nonalcoholic Steatohepatitis via M1 Macrophage Polarization"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3686-1377","authenticated-orcid":false,"given":"Yuxin","family":"Luo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9418-600X","authenticated-orcid":false,"given":"Jinbo","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1105-0746","authenticated-orcid":false,"given":"Wenxiu","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0510-8654","authenticated-orcid":false,"given":"Mengyao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3794-9522","authenticated-orcid":false,"given":"Fengrong","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guochao","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1335-7044","authenticated-orcid":false,"given":"David Q.","family":"Shih","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0265-5193","authenticated-orcid":false,"given":"Stephan R.","family":"Targan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7047-3634","authenticated-orcid":false,"given":"Xiaolan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,12,31]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000002484"},{"key":"e_1_2_9_2_2","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2020.154170","article-title":"Complications, morbidity and mortality of nonalcoholic c fatty liver disease","volume":"111","author":"Mantovani A.","year":"2020","journal-title":"Metabolism"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30251"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29068"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v25.i2.163"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.27834"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.11.7325"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0903782"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/liv.12296"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/7657294"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201444528"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0016090"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(82)82083-1"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22423"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-11304-8"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-018-0082-x"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-10-8684-7_4"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-019-0144-8"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.02.026"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26937"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.417014"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00285.2014"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2009.080999"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2015.06.015"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/iep.12020"},{"key":"e_1_2_9_26_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00213.2017"},{"key":"e_1_2_9_27_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v24.i48.5477"},{"key":"e_1_2_9_28_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1402709"}],"container-title":["Oxidative Medicine and Cellular Longevity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2021\/3877617.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2021\/3877617.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2021\/3877617","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T18:18:26Z","timestamp":1723054706000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2021\/3877617"}},"subtitle":[],"editor":[{"given":"Ramoji","family":"Kosuru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1155\/2021\/3877617"],"URL":"https:\/\/doi.org\/10.1155\/2021\/3877617","archive":["Portico"],"relation":{},"ISSN":["1942-0900","1942-0994"],"issn-type":[{"value":"1942-0900","type":"print"},{"value":"1942-0994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"2021-08-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"3877617"}}