{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T05:46:58Z","timestamp":1770702418375,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,11,28]],"date-time":"2021-11-28T00:00:00Z","timestamp":1638057600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100015690","name":"UNPAD","doi-asserted-by":"crossref","award":["RKDU 2021"],"award-info":[{"award-number":["RKDU 2021"]}],"id":[{"id":"10.13039\/501100015690","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Medicine International"],"published-print":{"date-parts":[[2021,11,28]]},"abstract":"<jats:p>Ancylostoma caninum is one of the most important hookworms in dogs. A study revealed that the prevalence of ancylostomiasis in Indonesia is relatively high. However, cases of persistent ancylostomiasis in dogs were reported, indicating the possibility of anthelmintic resistance. The aim of this review is to provide an overview of the anthelmintic potential of plants preclinically against A. caninum based on related research articles. This review retrieved 14 articles from 2001 to 2021 investigating 19 different plants. Momordica charantia, Diospyros anisandra, and Citrus aurantiifolia hold a promising prospect as anthelmintic against A. caninum. This review found aspects of those medicinal plants that need to be investigated deeper to improve our understanding of the matter. In vitro results in this review have not yet been tested in in vivo trials, which are essential in determining the efficacy and safety of the use of these medicinal plants and also to justify its clinical application.<\/jats:p>","DOI":"10.1155\/2021\/3879099","type":"journal-article","created":{"date-parts":[[2021,11,28]],"date-time":"2021-11-28T22:35:08Z","timestamp":1638138908000},"page":"1-6","source":"Crossref","is-referenced-by-count":4,"title":["Anthelmintic Potential of Medicinal Plants against Ancylostoma caninum"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8904-7811","authenticated-orcid":true,"given":"Savira","family":"Ekawardhani","sequence":"first","affiliation":[{"name":"Parasitology Division, Department of Biomedical Sciences, Faculty of Medicine, Padjadjaran University, Sumedang, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Utari T.","family":"Anggoro","sequence":"additional","affiliation":[{"name":"Veterinary Medicine Program, Faculty of Medicine, Padjadjaran University, Sumedang, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ita","family":"Krissanti","sequence":"additional","affiliation":[{"name":"Veterinary Medicine Program, Faculty of Medicine, Padjadjaran University, Sumedang, Indonesia"},{"name":"Microbiology Division, Department of Biomedical Science, Faculty of Medicine, Padjadjaran University, Sumedang, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","volume-title":"Daya Antihelmintika Infusa Biji Ceguk (Quisqualis Indica L.) Terhadap Cacing Kait Anjing (Ancylostoma spp.) Secara in Vitro","author":"R. W. Mulyaningsih","year":"2010"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2006.08.036"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-019-3828-6"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.4322\/nematoda.00916"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.5897\/ajpp2016.4551"},{"issue":"1","key":"6","first-page":"14","article-title":"In vitro activity of ethanol, cold water and hot water extracts of the bark of Canthium mannii (rubiaceae) stem on ancylostoma caninum eggs","volume":"9","author":"J. W. Pon\u00e9","year":"2006","journal-title":"East and Central African Journal of Pharmaceutical Sciences"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1079\/pavsnnr201510008"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2020.565103"},{"issue":"17","key":"9","doi-asserted-by":"crossref","first-page":"379","DOI":"10.5897\/AJPP2015.4505","article-title":"Larvicidal potential of Mikania glomerata SPRENGEL extract on Ancylostoma caninum larvae","volume":"10","author":"A. E. L. Ara\u00fajo","year":"2016","journal-title":"African Journal of Pharmacy and Pharmacology"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.5812\/archcid.27495"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1645\/ge-1446.1"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1055\/s-0042-108209"},{"issue":"1","key":"13","first-page":"2","article-title":"Anthelmintic effect of natural plant (Carica papaya) extract against the gastrointestinal nematode, Ancylostoma caninum in Mice","volume":"1","author":"S. Bi","year":"2012","journal-title":"ISCA Journal of Biological Sciences"},{"issue":"7","key":"14","first-page":"44","article-title":"Role of neem (Azardirachta indica) as a plant extract dewormer for Ancylostoma caninum infection in mice","volume":"1","author":"S. Bi","year":"2012","journal-title":"International Research Journal of Biological Sciences"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1080\/13880200701498978"},{"issue":"1","key":"16","first-page":"39","article-title":"Anthelmintic efficacy of the aqueous crude extract of Euphorbia hirta Linn in Nigerian dogs","volume":"75","author":"A. A. Adedapo","year":"2005","journal-title":"Veterinarski Arhiv"},{"issue":"9","key":"17","first-page":"104","article-title":"Synergistic anthelmintic effect of citrus aurantifolia swingle seeds and mebendazole in Egyptian dogs infected with ancylostoma caninum and Toxocara canis: trial to solve drug resistance problem","volume":"3","author":"M. A. Hassanain","year":"2015","journal-title":"International Journal of Research Studies in Biosciences (IJRSB)"},{"issue":"3","key":"18","first-page":"171","article-title":"In vivo anthelmintic activity of the ethanol extract of Allium cepa (onion) against mixed gastro intestinal helminth infestations in dogs","volume":"5","author":"K. O. A. Orengo","year":"2016","journal-title":"International Journal of Veterinary Science"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.29374\/2527-2179.bjvm019117"},{"key":"20","volume-title":"Principles of Veterinary Parasitology","author":"D. Jacobs","year":"2016"},{"key":"21","article-title":"The Cuticle, in WormBook","volume-title":"The C. elegans Research Community","author":"A. P. Page","year":"2007"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/480258"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2007.11.053"}],"container-title":["Veterinary Medicine International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/vmi\/2021\/3879099.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/vmi\/2021\/3879099.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/vmi\/2021\/3879099.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,28]],"date-time":"2021-11-28T22:35:33Z","timestamp":1638138933000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/vmi\/2021\/3879099\/"}},"subtitle":[],"editor":[{"given":"Nora","family":"Mestorino","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2021,11,28]]},"references-count":23,"alternative-id":["3879099","3879099"],"URL":"https:\/\/doi.org\/10.1155\/2021\/3879099","relation":{},"ISSN":["2042-0048","2090-8113"],"issn-type":[{"value":"2042-0048","type":"electronic"},{"value":"2090-8113","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11,28]]}}}