{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T03:19:36Z","timestamp":1764645576663,"version":"3.41.2"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,9,28]],"date-time":"2021-09-28T00:00:00Z","timestamp":1632787200000},"content-version":"vor","delay-in-days":270,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010031","name":"Postdoctoral Research Foundation of China","doi-asserted-by":"publisher","award":["2018M631838"],"award-info":[{"award-number":["2018M631838"]}],"id":[{"id":"10.13039\/501100010031","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81702136","81973887"],"award-info":[{"award-number":["81702136","81973887"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>Xianling Gubao Capsule (XGC), a kind of capsule preparation of Chinese herbal officially approved for sale by the National Medical Products Administration (NMPA), has the effect of tonifying kidney and strengthening bones. Although the impact of XGC in treating bone diseases has been widely studied, the effect of XGC in kidney injury is unknown yet. The kidney injury model is established by intraperitoneal injection with cadmium chloride (CdCl<jats:sub>2<\/jats:sub>). Before model establishment, each XGC group was pregavaged with XGC for 10\u2009d. After 10\u2009d, CdCl2 was injected intraperitoneally into the model group and each XGC group, each XGC group continued to be gavaged with XGC for 4 weeks, and the control group was gavaged with equal doses of distilled water once daily. The level of serum urea nitrogen (BUN) and serum creatinine (Cr) is evaluated by kit. The effect of XGC on protecting kidney injury in mice with kidney injury is analyzed by histopathology (HE stain), immunohistochemistry (IHC), and real\u2010time fluorescence quantitative PCR (RT\u2010qPCR). The results show that CdCl<jats:sub>2<\/jats:sub> significantly increases the level BUN and Cr in serum and results in remarkable pathological changes in the nephron, including tubule edema, congestion, and necrosis. While oral administration of XGC can significantly decrease BUN and Cr in serum and prevent and protect the kidney from the above injuries. In addition, the protein expression of p\u2010mTOR was remarkably reduced, and the ratio of LC3II\/LC3I protein and mRNA was significantly increased in mice with oral administration of XGC. Our findings suggest that XGC can prevent and protect kidney injury by improving the state of renal tubular hyperemia and necrosis and reduce the level of BUN and Cr in cadmium poisoning mice.<\/jats:p>","DOI":"10.1155\/2021\/3931750","type":"journal-article","created":{"date-parts":[[2021,9,29]],"date-time":"2021-09-29T00:35:49Z","timestamp":1632875749000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Xianling Gubao Capsule Prevents Cadmium\u2010Induced Kidney Injury"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4248-6101","authenticated-orcid":false,"given":"Jian","family":"Huang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8323-7553","authenticated-orcid":false,"given":"Xiao-tong","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5982-8326","authenticated-orcid":false,"given":"Duo-duo","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7542-1585","authenticated-orcid":false,"given":"Bao-jin","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5678-7410","authenticated-orcid":false,"given":"Da-qing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5278-4001","authenticated-orcid":false,"given":"Xiang-yang","family":"Leng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1889-6071","authenticated-orcid":false,"given":"Jia","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,9,28]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2020.126552"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00815"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17050662"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2015.11.021"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.4161\/auto.19419"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-10271-8"},{"key":"e_1_2_10_7_2","first-page":"21","article-title":"To analysis the clinical effect of Xianlinggubao capsule combined with alendronate sodium in the treatment of osteoporosis","volume":"13","author":"City G.","year":"2016","journal-title":"Journal of China Prescription Drug"},{"key":"e_1_2_10_8_2","first-page":"3018","article-title":"Proved cases of SHAO Zhao-di treating chronic renal failure with Caoguo Zhimu Decoction","volume":"32","author":"Wang W.-J.","year":"2017","journal-title":"China Journal of Traditional Chinese Medicine and Pharmacy"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11655-019-3064-0"},{"key":"e_1_2_10_10_2","first-page":"88","article-title":"Effect of Shenqi Dihuang powder on renal function for patients with acute renal injury in convalescent period","volume":"35","author":"Zhang Z. 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