{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:40:19Z","timestamp":1747190419267,"version":"3.40.5"},"reference-count":8,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,8,7]],"date-time":"2021-08-07T00:00:00Z","timestamp":1628294400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Neurological Medicine"],"published-print":{"date-parts":[[2021,8,7]]},"abstract":"<jats:p>Background. Hodgkin\u2019s disease involving the central nervous system is uncommon and is usually seen in patients with uncontrolled systemic disease or those who have had multiple episodes of recurrent disease. Common symptoms of intracranial Hodgkin\u2019s disease are motor and\/or sensory deficits, headache, papilloedema, coma, and seizures. The rarity of Hodgkin\u2019s disease presenting with intracranial involvement is marked, but patients presenting with cavernous sinus syndrome is even rarer. Despite its rarity, the presence of a cavernous sinus syndrome in a patient with a known history of Hodgkin\u2019s disease warrants full utilization of modern diagnostic techniques in terms of investigation. Case Presentation. A 34-year-old woman, known with previous Hodgkin\u2019s lymphoma and now in remission for the past 7 years, presented with signs and symptoms suggestive of a left cavernous sinus syndrome. She was otherwise systemically well with no other complaints. Extensive investigations revealed no obvious cause for the cavernous sinus syndrome. A CT chest revealed subclinical axillary lymphadenopathy, which on excisional biopsy confirmed recurrent Hodgkin\u2019s disease. The patient\u2019s sole clinical presentation of her recurrent disease was the cavernous sinus syndrome, with no other clinically obvious systemic signs or symptoms to suggest a relapse. This was treated with steroids, and clinical improvement was noted; she was referred to oncology for extensive chemotherapy. Conclusions. Whilst there is a paucity of literature around this topic, it must be remembered by the clinician that cavernous sinus syndrome may be the sole clinical presentation of recurrent Hodgkin\u2019s disease. Even though it is reported that lymphomatous involvement in the brain usually occurs late in the disease process, this case is evidence that cavernous sinus syndrome may precede other systemic signs and symptoms. Recognising this possibility will ensure a rigorous search for Hodgkin\u2019s disease, an early and effective diagnosis, and a better prognosis in affected patients.<\/jats:p>","DOI":"10.1155\/2021\/3946231","type":"journal-article","created":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T18:21:51Z","timestamp":1628533311000},"page":"1-4","source":"Crossref","is-referenced-by-count":0,"title":["Recurrent Hodgkin\u2019s Disease Presenting as a Clinically Isolated Cavernous Sinus Syndrome"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6239-2105","authenticated-orcid":true,"given":"Aayesha Jalaluddin","family":"Soni","sequence":"first","affiliation":[{"name":"Department of Neurology, University of Cape Town, Cape Town, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0210-843X","authenticated-orcid":true,"given":"Edward Bernard","family":"Lee-Pan","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Cape Town, Cape Town, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1097\/MPH.0b013e3181a712f3","article-title":"A rare presentation of central nervous system in a pediatric patient with Hodgkin disease cavernous sinus syndrome","volume":"31","author":"B. Aliglo","year":"2009","journal-title":"Journal of Pediatric Hematology\/Oncology"},{"issue":"3","key":"2","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1097\/00041327-199609000-00010","article-title":"Cavernous sinus syndrome in Hodgkin\u2019s disease","volume":"16","author":"S. E. Kasner","year":"1996","journal-title":"Journal of Neuro-Ophthalmology"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1080\/08880010500198863"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19831001)52:7<1301::aid-cncr2820520728>3.0.co;2-5"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1080\/10428190410001673409"},{"issue":"9","key":"6","first-page":"el80","article-title":"Intracranial involvement in a patient with Hodgkin\u2019s lymphoma","volume":"52","author":"M. Comert","year":"2011","journal-title":"Singapore Medical Journal"},{"issue":"5","key":"7","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.pediatrneurol.2009.12.008","article-title":"Lymphoma of the cavernous sinus mimicking tolosa-hunt syndrome in a child","volume":"42","author":"M. Demirkaya","year":"2009","journal-title":"Pediatric Neurology"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.71.5.577"}],"container-title":["Case Reports in Neurological Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crinm\/2021\/3946231.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crinm\/2021\/3946231.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crinm\/2021\/3946231.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T18:21:58Z","timestamp":1628533318000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/crinm\/2021\/3946231\/"}},"subtitle":[],"editor":[{"given":"Peter","family":"Berlit","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2021,8,7]]},"references-count":8,"alternative-id":["3946231","3946231"],"URL":"https:\/\/doi.org\/10.1155\/2021\/3946231","relation":{},"ISSN":["2090-6676","2090-6668"],"issn-type":[{"type":"electronic","value":"2090-6676"},{"type":"print","value":"2090-6668"}],"subject":[],"published":{"date-parts":[[2021,8,7]]}}}