{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:39:40Z","timestamp":1787027980150,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,9,13]],"date-time":"2021-09-13T00:00:00Z","timestamp":1631491200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Surgical Oncology"],"published-print":{"date-parts":[[2021,9,13]]},"abstract":"<jats:p>Objective. The main objective of the study was to determine the effect of the presence of mutation in the KRAS gene on the survival in patients with colorectal cancer (CRC) and peritoneal metastases (PM). Materials and Methods. A retrospective cohort study was performed. Patients diagnosed with CRC with synchronous or metachronous PM between January 2006 and December 2019 were included. Data on the histopathological, clinical, and treatment factors were collected. The effect of each variable on survival was evaluated by Cox regression. Results. A total of 149 patients were included (64 women (43%) and 85 men (57%); mean age, 63\u2009years). The long-term survival rate at 36\u2009months was 24% (median, 21 months). KRAS mutation was detected in 75 patients (50.3%). Kaplan\u2013Meier analysis estimated that likelihood of survival was higher in patients with wild-type KRAS tumours (35%) than in mutated-type KRAS (14%) (median: 28 vs. 15, respectively) (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>=<\/a:mo>\n                        <a:mn>0.001<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>). Within the categories into which the peritoneal cancer index (PCI) was classified, survival at 36 months depended on the KRAS status. Survival in wild-type KRAS tumours with PCI 1\u201310 was 71% and with PCI 11\u201320 was 26%, while in mutant-type KRAS tumours, survival was 41% and 4%, respectively (<jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>P<\/c:mi>\n                        <c:mo>=<\/c:mo>\n                        <c:mn>0.025<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>). In the multiple regression analysis, the KRAS mutation was revealed to have an independent prognostic value (HR: 2.144; 95% CI: 1.342\u20133.424). Conclusion. The mutational status of the KRAS gene has demonstrated a strong association with survival and prognostic utility in patients with CRC with PM.<\/jats:p>","DOI":"10.1155\/2021\/3946875","type":"journal-article","created":{"date-parts":[[2021,9,14]],"date-time":"2021-09-14T23:05:11Z","timestamp":1631660711000},"page":"1-9","source":"Crossref","is-referenced-by-count":6,"title":["Prognostic Value of KRAS Gene Mutation on Survival of Patients with Peritoneal Metastases of Colorectal Adenocarcinoma"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0993-8498","authenticated-orcid":true,"given":"Manuel","family":"D\u00edez-Alonso","sequence":"first","affiliation":[{"name":"Department of General and Digestive Surgery, Pr\u00edncipe de Asturias Teaching Hospital, Alcal\u00e1 de Henares, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1046-6344","authenticated-orcid":true,"given":"Fernando","family":"Mendoza-Moreno","sequence":"additional","affiliation":[{"name":"Department of General and Digestive Surgery, Pr\u00edncipe de Asturias Teaching Hospital, Alcal\u00e1 de Henares, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0049-5870","authenticated-orcid":true,"given":"Remedios","family":"G\u00f3mez-Sanz","sequence":"additional","affiliation":[{"name":"Department of General and Digestive Surgery, Pr\u00edncipe de Asturias Teaching Hospital, Alcal\u00e1 de Henares, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9209-7724","authenticated-orcid":true,"given":"Bel\u00e9n","family":"Mat\u00edas-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of General and Digestive Surgery, Pr\u00edncipe de Asturias Teaching Hospital, Alcal\u00e1 de Henares, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4254-3594","authenticated-orcid":true,"given":"Enrique","family":"Ovejero-Merino","sequence":"additional","affiliation":[{"name":"Department of General and Digestive Surgery, Pr\u00edncipe de Asturias Teaching Hospital, Alcal\u00e1 de Henares, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3744-2836","authenticated-orcid":true,"given":"Raquel","family":"Molina","sequence":"additional","affiliation":[{"name":"Department of Oncology, Pr\u00edncipe de Asturias Teaching Hospital, Alcal\u00e1 de Henares, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7746-3503","authenticated-orcid":true,"given":"Sonia","family":"Soto-Sch\u00fctte","sequence":"additional","affiliation":[{"name":"Department of General and Digestive Surgery, Pr\u00edncipe de Asturias Teaching Hospital, Alcal\u00e1 de Henares, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8597-4108","authenticated-orcid":true,"given":"Alberto","family":"San Juan","sequence":"additional","affiliation":[{"name":"Department of Oncology, Pr\u00edncipe de Asturias Teaching Hospital, Alcal\u00e1 de Henares, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3751-5676","authenticated-orcid":true,"given":"Alberto","family":"Gutierrez-Calvo","sequence":"additional","affiliation":[{"name":"Department of General and Digestive Surgery, Pr\u00edncipe de Asturias Teaching Hospital, Alcal\u00e1 de Henares, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.8679"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2014.04.004"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25596"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2019.10.035"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdw235"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2008.17.7147"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/s1470-2045(16)30500-9"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v25.i27.3484"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-014-3798-z"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1111\/codi.12552"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.21037\/jgo.2019.05.04"},{"key":"12","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1093\/annonc\/mdw235","article-title":"ESMO consensus guidelines for the management of patients with metastatic colorectal cancer","volume":"27","author":"E. 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