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However, data on their antibacterial activity on strains of bacteria responsible for infectious diarrhea are not available. This study is aimed at elucidating the mechanism of action of the antibacterial effect of these plants on some bacterial strains responsible for diarrheal infections. The design of the study included first evaluating the degree of sensitivity of <jats:italic>Salmonella typhimurium<\/jats:italic> 14028, <jats:italic>Escherichia coli<\/jats:italic> ATCC 25922, <jats:italic>Shigella<\/jats:italic> spp., and <jats:italic>Salmonella<\/jats:italic> spp. strains to aqueous and hydroethanolic extracts of each plant, followed by the determination of minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), and antibiotic power (Pa). This screening was completed with the evaluation of the possible mode of action of the extracts by testing the membrane permeability of these bacterial strains. The data collected indicate that the bacterial strains tested were sensitive to the extracts to varying degrees, except <jats:italic>Cassia sieberiana<\/jats:italic> DC and <jats:italic>Pseudocedrela kotschyi<\/jats:italic> extracts. For the active extracts, inhibition diameters ranged from 18.33\u2009mm to 7\u2009mm. With the exception of <jats:italic>Escherichia coli<\/jats:italic>, all strains were sensitive to the aqueous and hydroethanolic extracts of <jats:italic>Anacardium occidentale<\/jats:italic>. MICs vary between 3.37 and 25\u2009mg\/ml. Membrane permeability test data show that all active extracts affect the bacterial strains tested by attacking the stability of their outer membrane. For all active extracts, the high percentage of membrane destabilization of the bacteria is significantly (<jats:italic>p<\/jats:italic> &lt; 0.05) better than that of cefixime used as a reference. Thus, it appears that these extracts can destroy Gram\u2010negative bacteria and increase the fluidity and permeability of their cytoplasmic membrane. The knowledge of the mechanism of action of these extracts is an interesting contribution to the fundamental knowledge on the alternative that medicinal plants represent to antibiotics. These extracts can be used in the management of infectious diarrhea.<\/jats:p>","DOI":"10.1155\/2021\/4134713","type":"journal-article","created":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T22:05:59Z","timestamp":1631225159000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Percentage Destabilization Effect of Some West African Medicinal Plants on the Outer Membrane of Various Bacteria Involved in Infectious Diarrhea"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9047-7299","authenticated-orcid":false,"given":"Victorien","family":"Dougnon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1774-1695","authenticated-orcid":false,"given":"Edna","family":"Hounsa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7578-6595","authenticated-orcid":false,"given":"Eric","family":"Agbodjento","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lunga Paul","family":"Keilah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2622-4363","authenticated-orcid":false,"given":"Brice Boris","family":"Legba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3213-2433","authenticated-orcid":false,"given":"Kevin","family":"Sintondji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4952-1574","authenticated-orcid":false,"given":"Anny","family":"Afaton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Robert","family":"Klotoe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8160-5954","authenticated-orcid":false,"given":"Lamine","family":"Baba-Moussa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honor\u00e9","family":"Bankole","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,9]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2016.02.076"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)71877-8"},{"key":"e_1_2_9_3_2","unstructured":"WHO Statistiques sanitaires mondiales 2014 2014 https:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/112816\/WHO_HIS_HSI_14.1_fre.pdf?sequence=1."},{"key":"e_1_2_9_4_2","unstructured":"WSP-ESI-Benin Impacts \u00e9conomiques d\u2019un mauvais assainissement en afrique 2012 http:\/\/www.wsp.org\/sites\/wsp\/files\/publications\/WSP-ESI-Benin-french-brochure.pdf."},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0237076"},{"key":"e_1_2_9_6_2","volume-title":"Statistiques sanitaires mondiales 2011","author":"WHO","year":"2011"},{"key":"e_1_2_9_7_2","unstructured":"WHO Strat\u00e9gie de l\u2019OMS pour la M\u00e9decine Traditionnelle pour 2002\u20132005 2002 http:\/\/archives.who.int\/tbs\/trm\/s2298f.pdf."},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.4236\/abb.2020.1110031"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.2650060513"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2005.01.032"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.9734\/JABB\/2015\/13810"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2017.10.020"},{"key":"e_1_2_9_13_2","unstructured":"SamailaD. 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