{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T22:09:08Z","timestamp":1790892548246,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,11,3]],"date-time":"2021-11-03T00:00:00Z","timestamp":1635897600000},"content-version":"vor","delay-in-days":306,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007452","name":"Wu Jieping Medical Foundation","doi-asserted-by":"publisher","award":["320.6750.2020-03-07"],"award-info":[{"award-number":["320.6750.2020-03-07"]}],"id":[{"id":"10.13039\/100007452","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81772390"],"award-info":[{"award-number":["81772390"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>\n                    Osteoarthritis (OA), characterized by chronic systemic low\u2010level inflammation and cartilage degeneration, is a type of arthritis closely associated with aging. Inflammation and aging play a pivotal role in the occurrence and progression of OA. NLRP3 inflammasome is involved in many inflammatory and aging diseases, and NLRP3 inhibitor MCC950 has anti\u2010inflammatory and antisenescence effects on some diseases such as Alzheimer\u2019s disease. In the present study, we found that NLRP3 protein was upregulated in human and mouse OA cartilage. Moreover, NLRP3 and Caspase1 expression induced by IL\u20101\n                    <jats:italic>\u03b2<\/jats:italic>\n                    in chondrocytes was blocked by MCC950. In addition, MCC950 inhibited the expression of inflammatory mediators, matrix\u2010degrading enzymes, senescence marker protein P16 (INK4A), and\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010galactosidase, as well as excessive production of ROS. Meanwhile, MCC950 promoted autophagy\u2010related protein expression and autophagy flux under the inflammatory condition. However, autophagy inhibitor 3\u2010MA reversed anti\u2010inflammatory and anticatabolic effects of MCC950. In in vivo experiments, intra\u2010articular administration of MCC950 further showed its protective effect on cartilage degeneration. Bioinformatic analysis and in vitro experimental results revealed that MCC950 might play a protective role in cartilage by regulating Nrf2\/HO\u20101\/NQO1, PI3k\/Akt\/mTOR, P38\/MAPK, and JNK\/MAPK pathways. In conclusion, our work demonstrated that NLRP3 inhibitor MCC950 might serve as a promising strategy for OA treatment.\n                  <\/jats:p>","DOI":"10.1155\/2021\/4139048","type":"journal-article","created":{"date-parts":[[2021,11,3]],"date-time":"2021-11-03T21:50:10Z","timestamp":1635976210000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["MCC950, the NLRP3 Inhibitor, Protects against Cartilage Degradation in a Mouse Model of 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