{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T07:48:31Z","timestamp":1767167311447,"version":"build-2238731810"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T00:00:00Z","timestamp":1638230400000},"content-version":"vor","delay-in-days":333,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Hebei Health Department","award":["20210237"],"award-info":[{"award-number":["20210237"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>Studies have shown that COX\u20102 expression is upregulated in gastric cancer (GC) as well as in precancerous lesions and in Helicobacter pylori\u2010induced inflammation, suggesting that cyclooxygenase\u20102 (COX\u20102) may play an important role in gastric carcinogenesis. We attempted to investigate the role of clarithromycin with tinidazole on Helicobacter pylori\u2010related gastritis from the aspects of clinical effect and COX\u20102 expression. From January 2016 to January 2019, 130 patients with Helicobacter pylori\u2010related chronic gastritis were collected and grouped into the observation group (OG) and the control group (CG). Altogether, 80 patients in the OG were treated with clarithromycin with tinidazole, while 50 patients in the CG were treated with amoxicillin with metronidazole. Clinical symptom improvement time, content of COX\u20102 and B cell lymphoma\u20102 (BCL\u20102), content of inflammatory factors interleukin\u20101 (IL\u20101), IL\u20104, and C\u2010reactive protein (CRP), expression level of nutritional indicators serum albumin (ALB), realbumin (PA), and transferrin (TF), clearance of Helicobacter pylori, total effective rate, and incidence of adverse reactions were detected. Compared with the CG, the OG had shorter clinical symptom improvement time, lower COX\u20102 and Bcl\u20102, lower expression of inflammatory factors IL\u20101, IL\u20104, and CRP, higher expression of nutritional indicators ALB, TF, and PA, higher clearance rate of Helicobacter pylori, higher total effective rate, and lower incidence of adverse reactions. Clarithromycin combined with tinidazole can effectively improve the clinical effect of Helicobacter pylori\u2010related gastritis and reduce the expression level of COX\u20102.<\/jats:p>","DOI":"10.1155\/2021\/4171019","type":"journal-article","created":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T18:18:23Z","timestamp":1638296303000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["[Retracted] Clinical Effect of Clarithromycin Combined with Tinidazole on Helicobacter pylori\u2010Related Gastritis and Its Influence on COX\u20102 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