{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:41:08Z","timestamp":1747190468599,"version":"3.40.5"},"reference-count":25,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,8,10]],"date-time":"2021-08-10T00:00:00Z","timestamp":1628553600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Infectious Diseases"],"published-print":{"date-parts":[[2021,8,10]]},"abstract":"<jats:p>Introduction. Cytomegalovirus (CMV) is a linear double-stranded DNA virus that may cause severe and potentially fatal infection in immunocompromised hosts. In immunocompetent individuals, the infection is typically mild or asymptomatic. However, in the last years, some cases of severe cytomegalovirus infection in immunocompetent individuals have been described. Clinical Presentation. The authors present a male patient aged 42 years, without specific medical history, who presented a 15-day history of fever, headache, night sweats, odynophagia, and bilateral otalgia, without improvement after four days of therapy with amoxicillin\/clavulanic acid. Blood count and biochemistry were performed with liver cytolysis pattern. Chest teleradiography showed diffuse interstitial infiltrate. Thoracic CT scan revealed areas in a ground glass with a cross-linking component in the left and right upper lung lobes compatible with an inflammatory\/infectious process. Blood serology was positive for CMV IgG and IgM. The detection on blood and bronchoalveolar lavage of CMV DNA by polymerase chain reaction (PCR) was also positive. Ganciclovir was started based on the clinical features and the result of CMV serology. After 48 hours, there was a significant clinical improvement, with remission of fever, and he was discharged on the 13th day of hospitalization with oral valganciclovir, completing a 21-day antiviral course at home. Conclusion. With this clinical case, the authors highlight the importance of considering CMV infection in evaluating patients with pneumonia, even in immunocompetent ones, particularly in those with no clinical improvement with antibiotics instituted for bacterial pneumonia, and when other causes have been ruled out.<\/jats:p>","DOI":"10.1155\/2021\/4226386","type":"journal-article","created":{"date-parts":[[2021,8,10]],"date-time":"2021-08-10T21:35:08Z","timestamp":1628631308000},"page":"1-6","source":"Crossref","is-referenced-by-count":2,"title":["Cytomegalovirus Pulmonary Involvement in an Immunocompetent Adult"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8422-3129","authenticated-orcid":true,"given":"Helena","family":"Lu\u00eds","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Hospital Central do Funchal\u2013SESARAM, E.P.E Avenida Lu\u00eds de Cam\u00f5es N\u00ba 57, Funchal 9004-514, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6561-7632","authenticated-orcid":true,"given":"Carolina","family":"Barros","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hospital Central do Funchal\u2013SESARAM, E.P.E Avenida Lu\u00eds de Cam\u00f5es N\u00ba 57, Funchal 9004-514, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8159-7854","authenticated-orcid":true,"given":"Mariana","family":"Gomes","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hospital Central do Funchal\u2013SESARAM, E.P.E Avenida Lu\u00eds de Cam\u00f5es N\u00ba 57, Funchal 9004-514, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0909-1992","authenticated-orcid":true,"given":"Jos\u00e9 Lu\u00eds","family":"Andrade","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hospital Central do Funchal\u2013SESARAM, E.P.E Avenida Lu\u00eds de Cam\u00f5es N\u00ba 57, Funchal 9004-514, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy","family":"Faria","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Hospital Central do Funchal\u2013SESARAM, E.P.E Avenida Lu\u00eds de Cam\u00f5es N\u00ba 57, Funchal 9004-514, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.idcr.2017.10.008"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.idcr.2018.e00445"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.47.1480"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422x-5-47"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2017.149"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2019.7823"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-018-3262-2"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2012.08.010"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1086\/379711"},{"key":"10","first-page":"1069","article-title":"Enhanced susceptibility of proliferating endothelium to salivary gland virus under naturally occurring and experimental conditions","volume":"34","author":"F. 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