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An important pathophysiological characteristic of LIRI is endothelial barrier dysfunction, although the mechanism involved in this process remains unclear. VX765, a specific caspase\u20101 inhibitor, has been shown to have a protective effect against several diseases including sepsis, atherosclerosis, and glial inflammatory disease. The objective of this study was to determine whether VX765 had a protective effect in LIRI. The results showed that lung ischemia\/reperfusion (I\/R) and oxygen\/glucose deprivation and reoxygenation (OGD\/R) induced endothelial pyroptosis and barrier dysfunction characterized by an inflammatory response. Treatment with VX765 successfully alleviated I\/R\u2010 and OGD\/R\u2010induced endothelial pyroptosis and barrier dysfunction by inhibiting caspase\u20101 <jats:italic>in vivo<\/jats:italic> and <jats:italic>in vitro<\/jats:italic>. In conclusion, these findings showed that VX765 provided effective protection against lung I\/R\u2010induced endothelial pyroptosis and barrier dysfunction.<\/jats:p>","DOI":"10.1155\/2021\/4525988","type":"journal-article","created":{"date-parts":[[2021,12,22]],"date-time":"2021-12-22T23:35:51Z","timestamp":1640216151000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["VX765, a Specific Caspase\u20101 Inhibitor, Alleviates Lung Ischemia Reperfusion Injury by Suppressing Endothelial Pyroptosis and Barrier 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