{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T20:20:19Z","timestamp":1774642819268,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,10,7]],"date-time":"2021-10-07T00:00:00Z","timestamp":1633564800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Oncology"],"published-print":{"date-parts":[[2021,10,7]]},"abstract":"<jats:p>Background. To explore the effect of paroxetine combined with probiotics in patients with type 2 diabetes mellitus with gastrointestinal dysfunction and liver cancer and its effect on nutritional status. Materials and Methods. 96 patients with type 2 diabetes mellitus combined with gastrointestinal dysfunction and liver cancer were selected as subjects from March 2018 to March 2021. They were randomly divided into control group and observation group, with 48 cases in each group. The control group was treated with probiotics, and the observation group was combined with paroxetine on the basis of the control group. After 4 weeks of treatment, the gastrointestinal mucosal function, nutritional status, Hamilton Depression Scale (HAMD) and Hamilton Anxiety Scale (HAMA) score, and the safety were compared between the two groups. Results. The levels of D-lactic acid, PCT, and endotoxin in the observation group were (1.75\u2009\u00b1\u20090.38), (4.39\u2009\u00b1\u20090.79), and (0.20\u2009\u00b1\u20090.06), respectively, which were significantly lower than those in the control group (2.69\u2009\u00b1\u20090.46), (7.84\u2009\u00b1\u20091.32), and (0.29\u2009\u00b1\u20090.08) (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>&lt;<\/a:mo>\n                        <a:mn>0.05<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>). Moreover, the nutritional status TP, ALB, Hb, PA, and TLC levels of the observation group were higher than those of the control group (<jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>P<\/c:mi>\n                        <c:mo>&lt;<\/c:mo>\n                        <c:mn>0.05<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>). The HAMA and HAMD scores in the observation group were (5.76\u2009\u00b1\u20091.06) and (8.94\u2009\u00b1\u20091.26), respectively, which were significantly lower than those in the control group (10.69\u2009\u00b1\u20092.21) and (13.42\u2009\u00b1\u20092.34) (<jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>P<\/e:mi>\n                        <e:mo>&lt;<\/e:mo>\n                        <e:mn>0.05<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula>). However, there was no statistical significance in the incidence of nausea and vomiting, blurred vision, chest arthralgia, palpitation, anaesthesia, dizziness, and drowsiness between the two groups (<jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>P<\/g:mi>\n                        <g:mo>&gt;<\/g:mo>\n                        <g:mn>0.05<\/g:mn>\n                     <\/g:math>\n                  <\/jats:inline-formula>). Conclusions. Paroxetine combined with probiotics could help to improve the gastrointestinal mucosal function of patients with type 2 diabetes mellitus complicated with gastrointestinal dysfunction and liver cancer, improve the nutritional status of patients, and reduce anxiety and depression, and the drug was safe and worthy of promotion and application.<\/jats:p>","DOI":"10.1155\/2021\/4529915","type":"journal-article","created":{"date-parts":[[2021,10,7]],"date-time":"2021-10-07T22:33:24Z","timestamp":1633646004000},"page":"1-5","source":"Crossref","is-referenced-by-count":5,"title":["Effect of Paroxetine Combined with Probiotics in Patients with Type 2 Diabetes Mellitus Complicated with Gastrointestinal Dysfunction and Liver Cancer"],"prefix":"10.1155","volume":"2021","author":[{"given":"Yi","family":"Peng","sequence":"first","affiliation":[{"name":"Department of Emergency, Wuhan Central Hospital Chinese Construction Third Engineering Bureau, Wuhan 430070, Hubei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingxia","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, Shandong Binzhou Optimal Care Hospital, Binzhou 256606, Shandong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7974-5931","authenticated-orcid":true,"given":"Yeju","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrine, Hanzhong Central Hospital, Hanzhong 723000, Shaanxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","volume-title":"Yttrium-90 Microspheres for Intermediate-or Advanced-Stage Hepatocellular Carcinoma","author":"C. Young","year":"2021"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29210"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27406"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21338"},{"issue":"21","key":"5","article-title":"Impact of high deductible health plans on diabetes care quality and outcomes: systematic review","volume":"S1530-891X","author":"D. H. Jiang","year":"2021","journal-title":"Endocrine Practice"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1007\/s12603-020-1494-1"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-199909000-00014"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.61191"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21197122"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-021-00920-0"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-021-00481-x"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1177\/02698811211000765"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2019.05.015"},{"key":"14","first-page":"949","article-title":"[Effect of intensive insulin therapy on high mobility group box-1\/nuclear factor-kappaB pathway in severe traumatic brain injury patient with stress hyperglycemia]","volume":"31","author":"X. Zhu","year":"2019","journal-title":"Zhonghua Wei Zhong Bing Ji Jiu Yi Xue"},{"issue":"4","key":"15","first-page":"3190","article-title":"The effects of mindfulness-based stress reduction therapy combined with intensive education on the effectiveness of the care and the awareness rate in patients with arthritis and diabetes","volume":"13","author":"Q. Chen","year":"2021","journal-title":"American Journal of Tourism Research"},{"key":"16","first-page":"801","article-title":"Glycemic control improvement through treatment of depression using antidepressant drugs in patients with diabetes mellitus type 1","volume":"31","author":"J. Komorousova","year":"2010","journal-title":"Neuroendocrinology Letters"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2013.11.002"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1097-0142(19980601)82:11<2123::aid-cncr6>3.0.co;2-w"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2003.07.125"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/j.cdp.2007.10.001"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1172\/jci76307"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2021.105693"},{"issue":"4","key":"23","first-page":"16","article-title":"The effect of probiotic probio-fit combined with metformin on the efficacy and intestinal flora structure in patients with type 2 diabetes","volume":"19","author":"Y. Chen","year":"2019","journal-title":"Chinese Journal of Food Science"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2020.09.013"},{"issue":"11","key":"25","first-page":"149","article-title":"Effects of early enteral nutrition support through nasal jejunum tube combined with probiotics on nutritional status and intestinal mucosal damage in patients with severe acute pancreatitis","volume":"40","author":"J. He","year":"2020","journal-title":"Journal of Clinical and Pathology"}],"container-title":["Journal of Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jo\/2021\/4529915.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jo\/2021\/4529915.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jo\/2021\/4529915.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,7]],"date-time":"2021-10-07T22:33:33Z","timestamp":1633646013000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/jo\/2021\/4529915\/"}},"subtitle":[],"editor":[{"given":"Muhammad Wasim","family":"Khan","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2021,10,7]]},"references-count":25,"alternative-id":["4529915","4529915"],"URL":"https:\/\/doi.org\/10.1155\/2021\/4529915","relation":{},"ISSN":["1687-8469","1687-8450"],"issn-type":[{"value":"1687-8469","type":"electronic"},{"value":"1687-8450","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10,7]]}}}