{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T02:50:08Z","timestamp":1781405408963,"version":"3.54.1"},"reference-count":12,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,6,24]],"date-time":"2021-06-24T00:00:00Z","timestamp":1624492800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Hepatology"],"published-print":{"date-parts":[[2021,6,24]]},"abstract":"<jats:p>Bacillus Calmette and Gu\u00e9rin (BCG), widely used as a vaccination to prevent tuberculosis, is also used as immunotherapy, by intrabladder instillation, to treat superficial bladder cancers and prevent recurrence. Complications following instillation of BCG are most often localized reactions, such as cystitis or hematuria. They can more rarely be generalized and potentially severe such as hepatitis, pneumopathies, aortitis, and localization to hematopoietic tissue. We have reported the observation of a 47-year-old patient followed up for a bladder tumor operated for transurethral resection of the bladder, then having benefited from an instillation of BCG therapy complicated by occurrence a week later of an acute hepatitis. The diagnostic time was 2 days, and the outcome was favorable with corticosteroid therapy.<\/jats:p>","DOI":"10.1155\/2021\/4574879","type":"journal-article","created":{"date-parts":[[2021,6,25]],"date-time":"2021-06-25T18:50:06Z","timestamp":1624647006000},"page":"1-4","source":"Crossref","is-referenced-by-count":4,"title":["Acute Hepatitis Induced by Intravesical BCG Therapy: A Rare but Serious Complication"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1611-9893","authenticated-orcid":true,"given":"Hakima","family":"Abid","sequence":"first","affiliation":[{"name":"Department of Hepato-Gastroenterology, University Hospital Hassan II-Fez, Laboratory of Human Pathology, Biomedicine and Environment, Fes, Morocco"},{"name":"Faculty of Medicine and Pharmacy of Fez, Sidi Mohamed Ben Abdellah University Fez-Morocco, Fes, 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