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Consequently, inadequate reperfusion of the microcirculation causes secondary ischemia, aggravating the myocardial reperfusion injury. ATP\u2010sensitive potassium ion (K<jats:sub>ATP<\/jats:sub>) channels regulate the coronary blood flow and protect cardiomyocytes from ischemia\u2010reperfusion injury. Studies in animal models of myocardial ischemia\u2010reperfusion have illustrated that the opening of mitochondrial KATP (mito\u2010K<jats:sub>ATP<\/jats:sub>) channels alleviates endothelial dysfunction and reduces myocardial necrosis. By contrast, blocking mito\u2010K<jats:sub>ATP<\/jats:sub> channels aggravates microvascular necrosis and no\u2010reflow phenomenon following ischemia\u2010reperfusion injury. Nicorandil, as an antianginal drug, has been used for ischemic preconditioning (IPC) due to its mito\u2010K<jats:sub>ATP<\/jats:sub> channel\u2010opening effect, thereby limiting infarct size and subsequent severe ischemic insult. 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