{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T01:22:43Z","timestamp":1780708963446,"version":"3.54.1"},"reference-count":19,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Pediatrics"],"published-print":{"date-parts":[[2021,9,1]]},"abstract":"<jats:p>Objective. To evaluate the association of bone mineral biomarkers of calcium, phosphorus metabolism, and 25-hydroxy vitamin D with diastolic dysfunction of the left ventricle and left ventricle mass in predialysis chronic kidney children. Patients and Methods. A cross-sectional observational study was conducted on 60 children with chronic kidney disease and treated by conservative treatment from October 2018 to September 2019 in the Pediatric Nephrology and Cardiology Department at our University Hospital. Results. The most common causes of CKD were congenital renal anomalies accounted for 22 (36.67%) of the studied cases. The mean age of children was<jats:inline-formula><a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><a:mn>7.05<\/a:mn><a:mo>\u00b1<\/a:mo><a:mn>2.74<\/a:mn><a:mtext>\u2009<\/a:mtext><a:mtext>years<\/a:mtext><\/a:math><\/jats:inline-formula>, and 32 (53.33%) were males. The children who had a normal diastolic function were 32 (53.33%), while those who had diastolic dysfunction were 28 (46.67%). There was a statistically significant in serum phosphorus (<jats:inline-formula><c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><c:mi>p<\/c:mi><\/c:math><\/jats:inline-formula>value = 0.03), serum PTH (<jats:inline-formula><e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><e:mi>p<\/e:mi><\/e:math><\/jats:inline-formula>value = 0.002), and hypertension (<jats:inline-formula><g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><g:mi>p<\/g:mi><\/g:math><\/jats:inline-formula>value = 0.03). There was a statistically significant positive correlation between LVMI and iPTH level (<jats:inline-formula><i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><i:mi>r<\/i:mi><i:mo>=<\/i:mo><i:mn>0.89<\/i:mn><\/i:math><\/jats:inline-formula>,<jats:inline-formula><k:math xmlns:k=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><k:mi>p<\/k:mi><k:mo>\u2264<\/k:mo><k:mn>0.0001<\/k:mn><\/k:math><\/jats:inline-formula>), 25(OH) cholecalciferol (<jats:inline-formula><m:math xmlns:m=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><m:mi>r<\/m:mi><m:mo>=<\/m:mo><m:mo>\u2212<\/m:mo><m:mn>0.27<\/m:mn><\/m:math><\/jats:inline-formula>,<jats:inline-formula><o:math xmlns:o=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\"><o:mi>p<\/o:mi><o:mo>=<\/o:mo><o:mn>0.04<\/o:mn><\/o:math><\/jats:inline-formula>), serum Ca (<jats:inline-formula><q:math xmlns:q=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M9\"><q:mi>r<\/q:mi><q:mo>=<\/q:mo><q:mo>\u2212<\/q:mo><q:mn>0.37<\/q:mn><\/q:math><\/jats:inline-formula>,<jats:inline-formula><s:math xmlns:s=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M10\"><s:mi>p<\/s:mi><s:mo>=<\/s:mo><s:mn>0.004<\/s:mn><\/s:math><\/jats:inline-formula>), and serum phosphorus (<jats:inline-formula><u:math xmlns:u=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M11\"><u:mi>r<\/u:mi><u:mo>=<\/u:mo><u:mo>\u2212<\/u:mo><u:mn>0.45<\/u:mn><\/u:math><\/jats:inline-formula>,<jats:inline-formula><w:math xmlns:w=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M12\"><w:mi>p<\/w:mi><w:mo>=<\/w:mo><w:mn>0.0003<\/w:mn><\/w:math><\/jats:inline-formula>). Conclusion. Our results revealed that hyperparathyroidism, hyperphosphatemia, and hypertension were significantly associated with diastolic dysfunction while hypovitaminosis D was not significantly associated. Vitamin D deficiency was prevalent in all children with CKD. Biomarkers of mineral bone density were significantly associated with left ventricular hypertrophy and increased left ventricular mass index.<\/jats:p>","DOI":"10.1155\/2021\/4708452","type":"journal-article","created":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T08:13:48Z","timestamp":1630570428000},"page":"1-9","source":"Crossref","is-referenced-by-count":2,"title":["The Impact of Bone Mineral Biomarkers on Cardiac Dysfunction in Predialysis Chronic Kidney Disease Children"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0217-3258","authenticated-orcid":true,"given":"Safaa","family":"Ali","sequence":"first","affiliation":[{"name":"Pediatric Department, Sohag University, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7379-3329","authenticated-orcid":true,"given":"Mohamed","family":"Saber","sequence":"additional","affiliation":[{"name":"Pediatric Department, Sohag University, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1398-5905","authenticated-orcid":true,"given":"Mohamed","family":"Kassem","sequence":"additional","affiliation":[{"name":"Pediatric Department, Sohag University, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0158765"},{"key":"2","first-page":"1","article-title":"Improving Global Outcomes (KDIGO) CKD workgroup. KDIGO 2012 clinical practice guideline for the evaluation and management of chronic kidney disease","volume":"3","author":"Kidney Disease","year":"2013","journal-title":"Kidney International Supplements"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2002.125910"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1080\/08860220701805216"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-013-2504-x"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfp570"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.02260409"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5000304"},{"issue":"2","key":"9","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1542\/peds.58.2.259","article-title":"A simple estimate of glomerular filtration rate in children derived from body length and plasma creatinine","volume":"58","author":"G. Schwartz","year":"1976","journal-title":"Pediatrics"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(92)90385-Z"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2004.09.011"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.4103\/apc.APC_12_18"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-012-0489-z"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1007\/s12291-015-0524-y"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2005.01544.x"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1081\/JDI-100001291"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1136\/openhrt-2013-000011"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.4103\/0971-4065.59337"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2015.205"}],"container-title":["International Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijpedi\/2021\/4708452.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijpedi\/2021\/4708452.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijpedi\/2021\/4708452.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,8]],"date-time":"2023-01-08T13:44:43Z","timestamp":1673185483000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/ijpedi\/2021\/4708452\/"}},"subtitle":[],"editor":[{"given":"Alessandro","family":"Mussa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,9,1]]},"references-count":19,"alternative-id":["4708452","4708452"],"URL":"https:\/\/doi.org\/10.1155\/2021\/4708452","relation":{},"ISSN":["1687-9759","1687-9740"],"issn-type":[{"value":"1687-9759","type":"electronic"},{"value":"1687-9740","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9,1]]}}}