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We aim to predict the motor threshold for near\u2010rectangular stimuli to efficiently determine the motor threshold size before any experiments take place. Estimating the behavior of large\u2010scale networks requires dynamically accurate and efficient modeling. We utilized a Hodgkin\u2013Huxley (HH) type model to evaluate motor threshold values and computationally validated its function with known true threshold data from 50 participants trials from state\u2010of\u2010the\u2010art published datasets. For monophasic, bidirectional, and unidirectional rectangular stimuli in posterior\u2010anterior or anterior\u2010posterior directions as generated by the cTMS device, computational modeling of the HH model captured the experimentally measured population\u2010averaged motor threshold values at high precision (maximum error\u2009\u2264\u20098%). The convergence of our biophysically based modeling study with experimental data in humans reveals that the effect of the stimulus shape is strongly correlated with the activation kinetics of the voltage\u2010gated ion channels. The proposed method can reliably predict motor threshold size using the conductance\u2010based neuronal models and could therefore be embedded in new generation neurostimulators. Advancements in neural modeling will make it possible to enhance treatment procedures by reducing the number of delivered magnetic stimuli to participants.<\/jats:p>","DOI":"10.1155\/2021\/4716161","type":"journal-article","created":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T04:34:46Z","timestamp":1622522086000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Estimation of the Motor Threshold for Near\u2010Rectangular Stimuli Using the Hodgkin\u2013Huxley Model"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9449-0738","authenticated-orcid":false,"given":"Majid","family":"Memarian Sorkhabi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Wendt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus T.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy","family":"Denison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,5,31]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2015.02.001"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2020.02.031"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1109\/ACCESS.2017.2672566"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1109\/access.2021.3057829"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1088\/1741-2560\/11\/5\/056023"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2020.3024902"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s42452-021-04420-y"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2019.04.012"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1109\/tnsre.2019.2925904"},{"key":"e_1_2_9_10_2","article-title":"Active and resting motor threshold are efficiently obtained with adaptive threshold hunting","volume":"12","author":"Sen C. 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